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Sorted by significance (p<0.05) and Fitness z-Scores (highest impact first):

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Pathogen Locus Protein UniProt Gene Length Product p-Value Fitness z-Score  Precise fitness z-Score
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A0506  NP_232897.1  Q9K2M2  137 aa hypothetical protein 0.023 ●○○○○ -0.19 -0.191821799759171
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3856  AIK82406.1  338 aa zinc-binding dehydrogenase family protein <1e-323 ●○○○○ -0.19 -0.191193512969223
Porphyromonas gingivalis ATCC 33277  PGN_0076  WP_012457220.1  B2RGV0  669 aa conjugal transfer protein TraG 3.8e-11 ●○○○○ -0.19 -0.190952854838512
Porphyromonas gingivalis ATCC 33277  PGN_0076  WP_043876306.1  B2RGV0  147 aa hypothetical protein 3.8e-11 ●○○○○ -0.19 -0.190952854838512
Escherichia coli M12  CO715_17660  ATI07384.1  458 aa transcriptional regulator 2.3e-45 ●○○○○ -0.19 -0.190194653766245
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A0318  NP_232714.1  Q9K2P7  165 aa hypothetical protein 0.035 ●○○○○ -0.19 -0.189862343396343
Escherichia coli M12  CO715_18155  ATI07471.1  339 aa D-erythrose-4-phosphate dehydrogenase 0.0059 ●○○○○ -0.19 -0.189568715723499
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0528  NP_230179.1  Q9KUJ2  ispD  232 aa 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 0.047 ●○○○○ -0.19 -0.18929893862846
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3575  AIK82130.1  267 aa cellulose synthase operon protein YhjQ <1e-323 ●○○○○ -0.19 -0.189284522221124
Escherichia coli M12  CO715_10900  ATI06160.1  531 aa acetate CoA-transferase YdiF 4.2e-45 ●○○○○ -0.19 -0.189151423695001
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3240  AIK81801.1  518 aa hypothetical protein <1e-323 ●○○○○ -0.19 -0.188913118993808
Vibrio cholerae O1 biovar El Tor str. N16961  VC_1703  NP_231339.1  Q9KRD9  163 aa hypothetical protein 0.0061 ●○○○○ -0.19 -0.188598681866273
Escherichia coli M12  CO715_07465  ATI05566.1  417 aa paraquat-inducible protein A 2.3e-11 ●○○○○ -0.19 -0.188316839638005
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0578  NP_230229.1  Q9KUE3  189 aa hemolysin 0.00095 ●○○○○ -0.19 -0.188249953165264
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3451  AIK82007.1  459 aa 4 glycosyl hydrolase family protein <1e-323 ●○○○○ -0.19 -0.187799124154907
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3787  AIK82342.1  374 aa DNA protecting protein DprA <1e-323 ●○○○○ -0.19 -0.18772262482369
Escherichia coli M12  CO715_19320  ATI07677.1  212 aa NAD-dependent dehydratase 6.4e-50 ●○○○○ -0.19 -0.186856317538263
Escherichia coli M12  CO715_11050  ATI06190.1  309 aa 6-phosphofructokinase II 6.3e-22 ●○○○○ -0.19 -0.186439025509766
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A0518  NP_232909.1  Q9KM70  400 aa PTS system fructose-specific transporter subunit IIA/HPr protein 0.0042 ●○○○○ -0.19 -0.186198976019464
Escherichia coli M12  CO715_10875  ATI06155.1  118 aa DUF1870 domain-containing protein 2.6e-62 ●○○○○ -0.19 -0.18560444145277
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3265  AIK81826.1  419 aa L-rhamnose isomerase 5.7e-15 ●○○○○ -0.19 -0.185437999873227
Escherichia coli M12  CO715_18070  ATI07455.1  209 aa FMN-dependent NADH-azoreductase 3.4e-16 ●○○○○ -0.19 -0.185395795438521
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2604  AIK81201.1  342 aa 16S rRNA m2G1207 methyltransferase 7.4e-8 ●○○○○ -0.18 -0.184397323663286
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3152  AIK81724.1  299 aa carboxylate/amino acid/amine transporter family protein <1e-323 ●○○○○ -0.18 -0.183908829658566
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3474  AIK82030.1  205 aa hypothetical protein <1e-323 ●○○○○ -0.18 -0.183532367196751
Escherichia coli M12  CO715_08325  ATI05717.1  758 aa ATP-dependent Clp protease ATP-binding subunit ClpA 3.6e-19 ●○○○○ -0.18 -0.183517981310282
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2651  AIK81245.1  254 aa 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase/5-carboxymethyl-2-oxo-hex-3-ene-1,7-dioate decarboxylase <1e-323 ●○○○○ -0.18 -0.182888531669952
Escherichia coli M12  CO715_11445  ATI06265.1  60 aa DUF1869 domain-containing protein 0.03 ●○○○○ -0.18 -0.182474751239037
Escherichia coli M12  CO715_05905  ATI05294.1  223 aa tail assembly protein 0.049 ●○○○○ -0.18 -0.18205745921054
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_1057  AIK79680.1  374 aa outer membrane protein C 1.3e-6 ●○○○○ -0.18 -0.181980861858626
Escherichia coli M12  CO715_23550  ATI08424.1  804 aa ABC transporter permease 1.1e-41 ●○○○○ -0.18 -0.181640167182042
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2671  AIK81265.1  426 aa hypothetical protein <1e-323 ●○○○○ -0.18 -0.181612330129679
Vibrio cholerae O1 biovar El Tor str. N16961  VC_2518  NP_232147.1  Q9KP58  163 aa hypothetical protein 1.0e-5 ●○○○○ -0.18 -0.181333552181323
Escherichia coli M12  CO715_19755  ATI07755.1  319 aa acetylesterase 0.014 ●○○○○ -0.18 -0.181222875153544
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3835  AIK82385.1  221 aa bacterial regulatory, gntR family protein 2.7e-10 ●○○○○ -0.18 -0.180770683500184
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3454  AIK82010.1  463 aa xanP xanthine NCS2 transporter 2.0e-14 ●○○○○ -0.18 -0.180750134590811
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A0931  NP_233316.1  Q9KL18  460 aa hypothetical protein 0.026 ●○○○○ -0.18 -0.180501623392334
Porphyromonas gingivalis ATCC 33277  PGN_0159  WP_012457289.1  B2RH33  thiE  647 aa thiamine phosphate synthase 6.9e-13 ●○○○○ -0.18 -0.180247498561424
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2422  AIK81019.1  238 aa sugar fermentation stimulation protein 0.016 ●○○○○ -0.18 -0.180040508082007
Escherichia coli M12  CO715_13130  ATI06567.1  297 aa N-acetylneuraminate lyase 0.019 ●○○○○ -0.18 -0.179970999068051
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2995  AIK81580.1  741 aa type VII secretion system (T7SS), usher family protein <1e-323 ●○○○○ -0.18 -0.179929156429244
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3633  AIK82188.1  221 aa conserved hypothetical integral membrane family protein <1e-323 ●○○○○ -0.18 -0.179647325052008
Escherichia coli M12  CO715_00850  ATI04409.1  205 aa 2-dehydro-3-deoxy-6-phosphogalactonate aldolase 3.3e-24 ●○○○○ -0.18 -0.178927768996807
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4435  AIK82978.1  273 aa ABC transporter family protein 1.1e-6 ●○○○○ -0.18 -0.178639020367784
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2229  AIK80834.1  471 aa alkaline phosphatase H 5.7e-5 ●○○○○ -0.18 -0.178216637684752
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_5116  AIK83642.1  673 aa tonB-dependent siderophore receptor family protein 9.1e-5 ●○○○○ -0.18 -0.177937606337551
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3155  AIK81727.1  206 aa homoserine/Threonine efflux family protein 0.0032 ●○○○○ -0.18 -0.177244173620906
Vibrio cholerae O1 biovar El Tor str. N16961  VC_1542  NP_231182.1  Q9KRU2  282 aa DNA ligase 0.0001 ●○○○○ -0.18 -0.176976069970283
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A0066  NP_232467.1  Q9KN99  480 aa hypothetical protein 0.00019 ●○○○○ -0.18 -0.176804209068839
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A1053  NP_233435.2  Q9KKP9  131 aa hypothetical protein 0.001 ●○○○○ -0.18 -0.176431335525545
Escherichia coli M12  CO715_17020  ATI07266.1  373 aa hydrogenase formation protein HypD 4.4e-37 ●○○○○ -0.18 -0.175798078783074
Escherichia coli M12  CO715_05990  ATI08744.1  681 aa peptidyl-dipeptidase Dcp 2.7e-10 ●○○○○ -0.17 -0.174963494726078
Escherichia coli M12  CO715_04715  ATI05099.1  334 aa flagellar motor switch protein FliM 2.0e-12 ●○○○○ -0.17 -0.173711618640585
Escherichia coli M12  CO715_05315  ATI05199.1  308 aa motility protein B 0.00011 ●○○○○ -0.17 -0.173294326612087
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2732  AIK81322.1  37 aa hypothetical protein 0.029 ●○○○○ -0.17 -0.17192703147578
Vibrio cholerae O1 biovar El Tor str. N16961  VC_1951  NP_231585.1  Q9KQP7  368 aa cytochrome c-type protein YecK 0.00016 ●○○○○ -0.17 -0.171856159951129
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3289  AIK81850.1  313 aa hypothetical protein <1e-323 ●○○○○ -0.17 -0.171655828807791
Escherichia coli M12  CO715_04160  ATI05008.1  601 aa glutathione-regulated potassium-efflux system protein KefB 7.5e-5 ●○○○○ -0.17 -0.171625158498096
Escherichia coli M12  CO715_21430  ATI08062.1  232 aa transcriptional regulator YeiL 2.0e-36 ●○○○○ -0.17 -0.170373282412603
Escherichia coli M12  CO715_24585  ATI08606.1  378 aa alpha/beta hydrolase 4.7e-14 ●○○○○ -0.17 -0.170373282412603
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_1946  AIK80552.1  201 aa hypothetical protein 0.0068 ●○○○○ -0.17 -0.169704648999804
Vibrio cholerae O1 biovar El Tor str. N16961  VC_1162  NP_230807.1  Q9KSU4  245 aa hypothetical protein 0.0043 ●○○○○ -0.17 -0.169679751296426
Escherichia coli M12  CO715_18485  ATI07529.1  482 aa succinate-semialdehyde dehydrogenase I 2.0e-14 ●○○○○ -0.17 -0.169330052341359
Escherichia coli M12  CO715_23160  ATI08367.1  373 aa aminopeptidase 1.4e-49 ●○○○○ -0.17 -0.16912140632711
Escherichia coli M12  CO715_15235  ATI06947.1  292 aa sulfofructosephosphate aldolase 0.035 ●○○○○ -0.17 -0.168912760312861
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A0986  NP_233370.1  Q9KKW4  277 aa hypothetical protein 0.048 ●○○○○ -0.17 -0.168804204297987
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3722  AIK82276.1  304 aa amidohydrolase family protein 4.2e-14 ●○○○○ -0.17 -0.168749618538259
Porphyromonas gingivalis ATCC 33277  PGN_1521  WP_012458340.1  B2RKZ5  299 aa GLPGLI family protein 0.014 ●○○○○ -0.17 -0.168513223264599
Vibrio cholerae O1 biovar El Tor str. N16961  VC_1769  NP_231404.1  Q9KR74  793 aa DNA methylase HsdM 0.023 ●○○○○ -0.17 -0.16849027777285
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3536  AIK82092.1  392 aa bacterial regulatory helix-turn-helix, AraC family protein <1e-323 ●○○○○ -0.17 -0.168301362141447
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A0514  NP_232905.1  Q9KM74  227 aa hypothetical protein 0.0028 ●○○○○ -0.17 -0.167951842463104
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4713  AIK83247.1  318 aa transaldolase 9.0e-13 ●○○○○ -0.17 -0.167552787887593
Vibrio cholerae O1 biovar El Tor str. N16961  VC_1641  NP_231278.1  Q9KRJ9  257 aa hypothetical protein 0.015 ●○○○○ -0.17 -0.167252223884019
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2019  AIK80625.1  312 aa aldo/keto reductase family protein 2.0e-9 ●○○○○ -0.17 -0.167136604121903
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0927  NP_230574.1  Q9KTH5  250 aa UDP-N-acetyl-D-mannosamine transferase 0.011 ●○○○○ -0.17 -0.16671108546785
Escherichia coli M12  CO715_08380  ATI05727.1  322 aa NADH oxidoreductase 6.0e-10 ●○○○○ -0.17 -0.166617654156124
Porphyromonas gingivalis ATCC 33277  PGN_0039  WP_039416859.1  B2RGR3  777 aa beta-hexosaminidase 1.1e-12 ●○○○○ -0.17 -0.166548400827238
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4661  AIK83195.1  78 aa hypothetical protein 8.1e-8 ●○○○○ -0.17 -0.166014087114177
Escherichia coli M12  CO715_24405  ATI08576.1  416 aa group II intron reverse transcriptase/maturase 1.8e-90 ●○○○○ -0.17 -0.165783070099128
Escherichia coli M12  CO715_10785  ATI06139.1  700 aa aldehyde ferredoxin oxidoreductase 0.00033 ●○○○○ -0.17 -0.165783070099128
Porphyromonas gingivalis ATCC 33277  PGN_0141  WP_005873753.1  B2RH15  394 aa hypothetical protein <1e-323 ●○○○○ -0.17 -0.165703739628258
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3565  AIK82121.1  551 aa sulfatase family protein <1e-323 ●○○○○ -0.16 -0.164785421186935
Escherichia coli M12  CO715_08915  ATI05825.1  329 aa cyclic pyranopterin monophosphate synthase 1.0e-15 ●○○○○ -0.16 -0.164739840027884
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3833  AIK82383.1  312 aa malate dehydrogenase, NAD-dependent 0.00024 ●○○○○ -0.16 -0.164654813231194
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4673  AIK83207.1  335 aa hypothetical protein 2.1e-15 ●○○○○ -0.16 -0.164653958802882
Escherichia coli M12  CO715_04950  ATI05137.1  328 aa glycosyltransferase family 2 protein 0.026 ●○○○○ -0.16 -0.164322547999386
Escherichia coli M12  CO715_13100  ATI06561.1  472 aa glutamate synthase small subunit 1.4e-17 ●○○○○ -0.16 -0.164113901985137
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3222  AIK81783.1  366 aa tRNA (uracil-5-)-methyltransferase 3.3e-16 ●○○○○ -0.16 -0.164063738649089
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3963  AIK82511.1  332 aa branched-chain amino acid transport system / permease component family protein 3.8e-9 ●○○○○ -0.16 -0.163522186698957
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4233  AIK82778.1  182 aa fimbrial subunit type 1 0.0041 ●○○○○ -0.16 -0.163105106903003
Escherichia coli M12  CO715_20770  ATI07941.1  191 aa hypothetical protein 3.6e-7 ●○○○○ -0.16 -0.163070671913893
Escherichia coli M12  CO715_00795  ATI04400.1  440 aa 6-phospho-alpha-glucosidase 1.1e-23 ●○○○○ -0.16 -0.162236087856898
Escherichia coli M12  CO715_17090  ATI07280.1  208 aa protein-L-isoaspartate O-methyltransferase 4.2e-6 ●○○○○ -0.16 -0.162236087856898
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3347  AIK81904.1  515 aa lamB porin family protein <1e-323 ●○○○○ -0.16 -0.162235721120821
Porphyromonas gingivalis ATCC 33277  PGN_0594  WP_012457629.1  B2RIB8  traN  311 aa conjugative transposon protein TraN 5.6e-8 ●○○○○ -0.16 -0.161401824987744
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2811  AIK81400.1  315 aa trehalose operon repressor 5.4e-8 ●○○○○ -0.16 -0.161324715755596
Escherichia coli M12  CO715_19260  ATI07666.1  436 aa amidohydrolase 1.1e-28 ●○○○○ -0.16 -0.160984211771405
Escherichia coli M12  CO715_24315  ATI08560.1  257 aa hypothetical protein 2.9e-25 ●○○○○ -0.16 -0.160984211771405
Vibrio cholerae O1 biovar El Tor str. N16961  VC_1111  NP_230756.1  Q9KSZ5  bioA  428 aa adenosylmethionine--8-amino-7-oxononanoate aminotransferase BioA 0.0092 ●○○○○ -0.16 -0.160914899642755
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4381  AIK82924.1  147 aa flavodoxin family protein <1e-323 ●○○○○ -0.16 -0.15925947067703
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