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Sorted by significance (p<0.05) and Fitness z-Scores (highest impact first):

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Pathogen Locus Protein UniProt Gene Length Product p-Value Fitness z-Score  Precise fitness z-Score
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3078  AIK81663.1  434 aa isocitrate lyase 1.8e-15 ●○○○○ -0.9 -0.898960138362041
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2806  AIK81395.1  150 aa toxin-antitoxin biofilm protein 5.6e-7 ●○○○○ -0.9 -0.898624269355331
Porphyromonas gingivalis ATCC 33277  PGN_0483  WP_012457545.1  B2RI07  355 aa galactose mutarotase 2.5e-10 ●○○○○ -0.9 -0.898484829712795
Salmonella enterica Serovar Typhimurium ST4 74  STM474_2880  WP_001520307.1  E8XJA5  689 aa DUF927 domain-containing protein 3.4e-5 ●○○○○ -0.9 -0.897477213364036
Escherichia coli M12  CO715_18795  ATI07583.1  356 aa 3-deoxy-7-phosphoheptulonate synthase 7.7e-16 ●○○○○ -0.9 -0.896670058012889
Escherichia coli M12  CO715_14330  ATI06779.1  660 aa TonB-dependent receptor 1.3e-35 ●○○○○ -0.9 -0.89646141199864
Escherichia coli M12  CO715_21120  ATI08008.1  542 aa anaerobic glycerol-3-phosphate dehydrogenase subunit A 2.8e-27 ●○○○○ -0.9 -0.89646141199864
Escherichia coli M12  CO715_06305  ATI05364.1  417 aa voltage-gated potassium channel 2.7e-35 ●○○○○ -0.9 -0.896252765984392
Escherichia coli M12  CO715_19380  ATI07689.1  325 aa phage shock protein operon transcriptional activator 0.00014 ●○○○○ -0.9 -0.896044119970143
Escherichia coli M12  CO715_04580  ATI05076.1  211 aa sulfoxide reductase heme-binding subunit YedZ 3.2e-34 ●○○○○ -0.9 -0.895418181927396
Escherichia coli M12  CO715_21395  ATI08056.1  393 aa sugar efflux transporter SetB 3.5e-12 ●○○○○ -0.9 -0.895209535913147
Escherichia coli M12  CO715_21610  ATI08094.1  310 aa D-alanyl-D-alanine endopeptidase 7.1e-61 ●○○○○ -0.89 -0.894583597870401
Escherichia coli M12  CO715_05960  ATI05302.1  427 aa MFS transporter 6.0e-33 ●○○○○ -0.89 -0.894374951856152
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A0362  NP_232757.1  Q9KMI7  102 aa hypothetical protein 0.012 ●○○○○ -0.89 -0.894158672947657
Acinetobacter baumannii ATCC 17978  A1S_0639  ABO11088.2  294 aa IncC protein 5.8e-5 ●○○○○ -0.89 -0.893623187839578
Escherichia coli M12  CO715_01130  ATI04458.1  330 aa asparagine synthetase A 3.7e-9 ●○○○○ -0.89 -0.893331721784908
Escherichia coli M12  CO715_22625  ATI08275.1  450 aa cell envelope integrity protein CreD 6.3e-10 ●○○○○ -0.89 -0.89291442975641
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0899  NP_230546.1  Q9KTK3  457 aa hypothetical protein 6.9e-7 ●○○○○ -0.89 -0.892402173032786
Escherichia coli M12  CO715_11335  ATI06244.1  358 aa alcohol dehydrogenase 1.8e-23 ●○○○○ -0.89 -0.891871199685166
Porphyromonas gingivalis ATCC 33277  PGN_0282  WP_043876311.1  B2RHF6  590 aa bifunctional metallophosphatase/5'-nucleotidase <1e-323 ●○○○○ -0.89 -0.891814560133989
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2706  AIK81296.1  114 aa periplasmic copper/silver-binding protein <1e-323 ●○○○○ -0.89 -0.891693065265998
Escherichia coli M12  CO715_09980  ATI06009.1  50 aa protein HokE 5.2e-6 ●○○○○ -0.89 -0.891245261642419
Salmonella enterica Serovar Typhimurium ST4 74  STM474_0646  WP_001277836.1  E8X9Y4  dpiB  553 aa sensor histidine kinase DpiB 0.0019 ●○○○○ -0.89 -0.891222101807339
Escherichia coli M12  CO715_22225  ATI08209.1  376 aa dTDP-4-amino-4,6-dideoxygalactose transaminase 1.5e-29 ●○○○○ -0.89 -0.890827969613921
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4144  AIK82690.1  957 aa glycine dehydrogenase <1e-323 ●○○○○ -0.89 -0.890594645182373
Escherichia coli M12  CO715_03515  ATI04887.1  189 aa 3-octaprenyl-4-hydroxybenzoate carboxy-lyase 2.8e-100 ●○○○○ -0.89 -0.889784739542677
Escherichia coli M12  CO715_18800  ATI07584.1  373 aa bifunctional chorismate mutase/prephenate dehydrogenase 0.0061 ●○○○○ -0.89 -0.889784739542677
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_1985  AIK80591.1  194 aa bacterial regulatory, tetR family protein 7.0e-6 ●○○○○ -0.89 -0.88937556177052
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3395  WP_000867323.1  E8XC58  tdcE  764 aa formate C-acetyltransferase 0.00073 ●○○○○ -0.89 -0.889260414851215
Escherichia coli M12  CO715_08770  ATI05798.1  240 aa glutamine ABC transporter ATP-binding protein 6.3e-24 ●○○○○ -0.89 -0.888115571428686
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2870  AIK81459.1  91 aa hypothetical protein 2.6e-10 ●○○○○ -0.89 -0.887292615119137
Escherichia coli M12  CO715_20860  ATI07959.1  134 aa flagellar basal body rod protein FlgC 0.0033 ●○○○○ -0.89 -0.887072341357442
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A0385  NP_232779.1  Q9K3B3  111 aa hypothetical protein 0.00018 ●○○○○ -0.89 -0.886921325616769
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_1195  AIK79818.1  452 aa indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase <1e-323 ●○○○○ -0.89 -0.886919473802629
Escherichia coli M12  CO715_08530  ATI05755.1  85 aa GrxA family glutaredoxin 0.0014 ●○○○○ -0.89 -0.886446403314695
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A0875  NP_233261.1  Q9KL72  dsdA  441 aa D-serine dehydratase 1.2e-9 ●○○○○ -0.89 -0.886337450123964
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0575  NP_230226.1  Q9KUE6  245 aa ubiquinol--cytochrome c reductase cytochrome c1 1.4e-8 ●○○○○ -0.89 -0.885583894566989
Acinetobacter baumannii ATCC 17978  A1S_1068  ABO11499.1  A3M3K6  argG  148 aa argininosuccinate synthetase 3.4e-8 ●○○○○ -0.89 -0.885107084758573
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4282  AIK82827.1  72 aa putative lipoprotein 3.5e-9 ●○○○○ -0.88 -0.884552568868707
Escherichia coli M12  CO715_21340  ATI08045.1  529 aa microcin C ABC transporter ATP-binding protein YejF 4.9e-8 ●○○○○ -0.88 -0.884359943172206
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2516  AIK81113.1  968 aa DEAD/DEAH box helicase family protein 1.1e-13 ●○○○○ -0.88 -0.88358554106087
Escherichia coli M12  CO715_09360  ATI05900.1  247 aa Nif3-like dinuclear metal center hexameric protein 2.1e-137 ●○○○○ -0.88 -0.883316713100962
Escherichia coli M12  CO715_20785  ATI07944.1  372 aa N-methyl-L-tryptophan oxidase 1.3e-59 ●○○○○ -0.88 -0.883108067086713
Salmonella enterica Serovar Typhimurium ST4 74  STM474_4798  WP_001056986.1  E8XDC6  sthD  185 aa fimbrial protein SthD 0.0073 ●○○○○ -0.88 -0.88290309592537
Escherichia coli M12  CO715_11490  ATI06273.1  561 aa long-chain-fatty-acid--CoA ligase 3.0e-9 ●○○○○ -0.88 -0.882899421072465
Escherichia coli M12  CO715_10435  ATI06078.1  239 aa DNA-binding response regulator 2.0e-15 ●○○○○ -0.88 -0.882690775058216
Acinetobacter baumannii ATCC 17978  A1S_2458  ABO12876.2  364 aa putative fatty acid desaturase 0.0048 ●○○○○ -0.88 -0.882590685053991
Escherichia coli M12  CO715_11950  ATI06357.1  328 aa hydrogenase-2 operon protein HybA 2.2e-39 ●○○○○ -0.88 -0.882482129043967
Salmonella enterica Serovar Typhimurium ST4 74  STM474_2865  WP_000562051.1  E8XJ90  86 aa hypothetical protein 0.049 ●○○○○ -0.88 -0.881482876619088
Escherichia coli M12  CO715_14235  ATI08816.1  122 aa glutamate decarboxylase 2.6e-5 ●○○○○ -0.88 -0.881438898972722
Salmonella enterica Serovar Typhimurium ST4 74  STM474_4560  WP_000312505.1  E8XAN9  hflK  419 aa FtsH protease activity modulator HflK 0.026 ●○○○○ -0.88 -0.880508780337556
Acinetobacter baumannii ATCC 17978  A1S_1657  ABO12084.2  206 aa putative siderophore biosynthesis protein; putative acetyltransferase 0.0031 ●○○○○ -0.88 -0.880426658906717
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0947  NP_230594.1  Q9KTF5  391 aa D-alanyl-D-alanine carboxypeptidase 4.4e-7 ●○○○○ -0.88 -0.880136832910117
Porphyromonas gingivalis ATCC 33277  PGN_1495  WP_012458317.1  B2RKW9  344 aa aminotransferase class V-fold PLP-dependent enzyme 0.037 ●○○○○ -0.88 -0.879800267295948
Porphyromonas gingivalis ATCC 33277  PGN_1495  WP_012458318.1  B2RKX0  133 aa DUF4248 domain-containing protein 0.037 ●○○○○ -0.88 -0.879800267295948
Salmonella enterica Serovar Typhimurium ST4 74  STM474_0625  WP_000118144.1  E8X976  ybdN  411 aa phosphoadenosine phosphosulfate reductase 0.00054 ●○○○○ -0.88 -0.879480183533852
Salmonella enterica Serovar Typhimurium ST4 74  STM474_4274  WP_001293360.1  E8XKF9  hslU  443 aa HslU--HslV peptidase ATPase subunit 0.027 ●○○○○ -0.88 -0.878998557038788
Acinetobacter baumannii ATCC 17978  A1S_1733  ABO12160.2  293 aa putative transcriptional regulator (LysR family) 0.0081 ●○○○○ -0.88 -0.877894617727903
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2860  AIK81449.1  274 aa bacterial regulatory helix-turn-helix, AraC family protein <1e-323 ●○○○○ -0.88 -0.877061037135237
Escherichia coli M12  CO715_01505  ATI04523.1  117 aa hypothetical protein 0.02 ●○○○○ -0.88 -0.876640040644999
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4071  AIK82618.1  103 aa gram-negative pili assembly chaperone, C-terminal domain protein 0.00082 ●○○○○ -0.88 -0.875765491085267
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2388  AIK80985.1  385 aa cdaR transcriptional activator 4.2e-11 ●○○○○ -0.88 -0.875381822778105
Escherichia coli M12  CO715_11770  ATI06323.1  275 aa phosphodiesterase 0.00013 ●○○○○ -0.87 -0.873718996445515
Escherichia coli M12  CO715_11210  ATI06220.1  235 aa TVP38/TMEM64 family protein 0.00038 ●○○○○ -0.87 -0.873510350431266
Escherichia coli M12  CO715_13690  ATI08811.1  237 aa oxidoreductase 1.6e-11 ●○○○○ -0.87 -0.87267576637427
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4085  AIK82631.1  239 aa hypothetical protein <1e-323 ●○○○○ -0.87 -0.872420687470254
Escherichia coli M12  CO715_21100  ATI08004.1  65 aa hypothetical protein 0.00012 ●○○○○ -0.87 -0.872258474345773
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3823  AIK82373.1  1236 aa hypothetical protein <1e-323 ●○○○○ -0.87 -0.87223904241984
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_1616  AIK80236.1  49 aa hypothetical protein 0.0014 ●○○○○ -0.87 -0.872081416600331
Escherichia coli M12  CO715_11095  ATI06199.1  753 aa catalase HPII 3.2e-61 ●○○○○ -0.87 -0.872049828331524
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3727  AIK82282.1  200 aa stationary-phase protein with possible role in p-aminobenzoate/folate biosynthesis <1e-323 ●○○○○ -0.87 -0.871805035267212
Salmonella enterica Serovar Typhimurium ST4 74  STM474_0498  WP_000178249.1  E8X864  aefA  1120 aa mechanosensitive channel MscK 0.03 ●○○○○ -0.87 -0.87149056028498
Salmonella enterica Serovar Typhimurium ST4 74  STM474_0907  WP_001149782.1  E8XCM8  rumb  376 aa 23S rRNA (uracil(747)-C(5))-methyltransferase RlmC 0.00027 ●○○○○ -0.87 -0.871066572011642
Porphyromonas gingivalis ATCC 33277  PGN_1768  WP_012458516.1  B2RLP2  961 aa response regulator 1.4e-8 ●○○○○ -0.87 -0.870559705124566
Salmonella enterica Serovar Typhimurium ST4 74  STM474_2385  WP_000992941.1  E8XED1  rhmA  267 aa 2-keto-3-deoxy-L-rhamnonate aldolase 0.028 ●○○○○ -0.87 -0.870503455169652
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3364  AIK81921.1  354 aa hypothetical protein <1e-323 ●○○○○ -0.87 -0.869923413407085
Escherichia coli M12  CO715_11380  ATI06253.1  491 aa GGDEF domain-containing protein 4.8e-218 ●○○○○ -0.87 -0.869754722174786
Salmonella enterica Serovar Typhimurium ST4 74  STM474_4076  WP_000840996.1  E8XIK9  yifE  112 aa macrodomain Ori organization protein MaoP 1.5e-5 ●○○○○ -0.87 -0.868859877043316
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2389  AIK80986.1  433 aa degP 6.7e-16 ●○○○○ -0.87 -0.867903904276841
Acinetobacter baumannii ATCC 17978  A1S_0881  ABO11313.2  A3M319  minC  240 aa cell division inhibitor 0.00089 ●○○○○ -0.87 -0.867690857018774
Escherichia coli M12  CO715_04440  ATI05054.1  316 aa transcriptional regulator Cbl 0.00062 ●○○○○ -0.87 -0.867042323989551
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3488  AIK82044.1  198 aa cell division inhibitor <1e-323 ●○○○○ -0.87 -0.86697816947006
Vibrio cholerae O1 biovar El Tor str. N16961  VC_2532  NP_232160.1  Q9KP47  286 aa hypothetical protein 6.9e-6 ●○○○○ -0.87 -0.866926436896364
Escherichia coli M12  CO715_04990  ATI05145.1  388 aa UDP-glucose 6-dehydrogenase 2.5e-23 ●○○○○ -0.87 -0.866833677975302
Porphyromonas gingivalis ATCC 33277  PGN_2010  WP_012458682.1  B2RMD3  493 aa hypothetical protein 7.2e-5 ●○○○○ -0.87 -0.866499813598004
Escherichia coli M12  CO715_07620  ATI05596.1  71 aa protein bdm 3.0e-27 ●○○○○ -0.87 -0.865790447904058
Porphyromonas gingivalis ATCC 33277  PGN_1360  WP_039417125.1  B2RKI4  68 aa hypothetical protein 7.3e-6 ●○○○○ -0.87 -0.86554507981413
Porphyromonas gingivalis ATCC 33277  PGN_1360  WP_004584492.1  B2RKI4  241 aa SDR family NAD(P)-dependent oxidoreductase 7.3e-6 ●○○○○ -0.87 -0.86554507981413
Escherichia coli M12  CO715_17645  ATI07382.1  163 aa hypothetical protein 0.00081 ●○○○○ -0.86 -0.864955863847062
Porphyromonas gingivalis ATCC 33277  PGN_1474  WP_012458299.1  B2RKU8  luxS  159 aa S-ribosylhomocysteine lyase <1e-323 ●○○○○ -0.86 -0.864589403264844
Escherichia coli M12  CO715_08250  ATI05705.1  814 aa dimethylsulfoxide reductase subunit A 3.8e-31 ●○○○○ -0.86 -0.863912633775818
Escherichia coli M12  CO715_00825  ATI04405.1  110 aa YceK/YidQ family lipoprotein 2.3e-27 ●○○○○ -0.86 -0.862869403704574
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2654  AIK81248.1  126 aa 5-carboxymethyl-2-hydroxymuconate Delta-isomerase 8.4e-9 ●○○○○ -0.86 -0.862842860747616
Escherichia coli M12  CO715_21075  ATI08001.1  1148 aa transcription-repair coupling factor 4.0e-16 ●○○○○ -0.86 -0.862660757690325
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3009  AIK81594.1  78 aa hypothetical protein <1e-323 ●○○○○ -0.86 -0.86264995648728
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0393  NP_230047.1  Q9KUW6  597 aa hypothetical protein 8.5e-7 ●○○○○ -0.86 -0.862396745193914
Escherichia coli M12  CO715_04325  ATI05040.1  196 aa hypothetical protein 4.0e-5 ●○○○○ -0.86 -0.861617527619081
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4066  AIK82613.1  456 aa CBS domain protein 4.8e-13 ●○○○○ -0.86 -0.861155492023929
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0706  NP_230355.1  Q9KU23  108 aa sigma-54 modulation protein 9.2e-7 ●○○○○ -0.86 -0.861133375604841
Escherichia coli M12  CO715_21375  ATI08052.1  328 aa GTP-binding protein 0.041 ●○○○○ -0.86 -0.860782943562085
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