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Sorted by significance (p<0.05) and Fitness z-Scores (highest impact first):

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Pathogen Locus Protein UniProt Gene Length Product p-Value Fitness z-Score  Precise fitness z-Score
Escherichia coli M12  CO715_05650  ATI08737.1  89 aa capsid protein 2.1e-5 ●○○○○ -0.04 -0.0433078597350468
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2250  AIK80855.1  258 aa ethanolamine ammonia-lyase light chain family protein 0.022 ●○○○○ -0.04 -0.0427231190383312
Escherichia coli M12  CO715_00835  ATI08698.1  366 aa colicin M resistance protein CbrA 2.0e-5 ●○○○○ -0.04 -0.0426819216923002
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3659  AIK82214.1  281 aa ugpE 1.2e-12 ●○○○○ -0.04 -0.0423090857194523
Escherichia coli M12  CO715_17560  ATI07366.1  719 aa bifunctional 2-acylglycerophosphoethanolamine acyltransferase/acyl-ACP synthetase 2.7e-22 ●○○○○ -0.04 -0.0422646296638025
Vibrio cholerae O1 biovar El Tor str. N16961  VC_1179  NP_230824.1  Q9KSS7  rluB  321 aa 23S rRNA pseudouridylate synthase B 0.0012 ●○○○○ -0.04 -0.0422297415022523
Escherichia coli M12  CO715_12590  ATI06470.1  443 aa threonine/serine transporter TdcC 6.7e-36 ●○○○○ -0.04 -0.0418473376353048
Escherichia coli M12  CO715_23520  ATI08418.1  225 aa iron export ATP-binding protein FetA 6.7e-23 ●○○○○ -0.04 -0.0418473376353048
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_1808  AIK80421.1  310 aa hypothetical protein 0.0014 ●○○○○ -0.04 -0.0411819329652778
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A0380  NP_232774.2  Q9KMH4  178 aa hypothetical protein 0.018 ●○○○○ -0.04 -0.0411667465564006
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0667  NP_230316.1  Q9KU57  352 aa aldo/keto reductase 0.0019 ●○○○○ -0.04 -0.0410419766766722
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A0350  NP_232746.1  Q9KMJ6  171 aa lipoprotein Blc 0.0017 ●○○○○ -0.04 -0.040834234684784
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4585  AIK83123.1  857 aa ATP-dependent chaperone protein ClpB <1e-323 ●○○○○ -0.04 -0.0406443982060731
Escherichia coli M12  CO715_12255  ATI06412.1  183 aa dTDP-4-dehydrorhamnose 3,5-epimerase 0.019 ●○○○○ -0.04 -0.0401781695213139
Vibrio cholerae O1 biovar El Tor str. N16961  VC_1235  NP_230880.1  Q9KSM1  471 aa sodium/dicarboxylate symporter 0.00053 ●○○○○ -0.04 -0.039631222750796
Vibrio cholerae O1 biovar El Tor str. N16961  VC_1280  NP_230925.1  Q9KSH6  431 aa hypothetical protein 0.0017 ●○○○○ -0.04 -0.0393245501842354
Porphyromonas gingivalis ATCC 33277  PGN_0426  WP_004583970.1  B2RHV0  158 aa hypothetical protein 3.7e-12 ●○○○○ -0.04 -0.0392789850950402
Vibrio cholerae O1 biovar El Tor str. N16961  VC_1519  NP_231159.2  Q9KRW5  fdhD  277 aa formate dehydrogenase accessory protein 0.016 ●○○○○ -0.04 -0.0390324715551428
Vibrio cholerae O1 biovar El Tor str. N16961  VC_1084  NP_230729.1  Q9KT21  439 aa sensory box sensor histidine kinase 1.4e-5 ●○○○○ -0.04 -0.0388826996293005
Porphyromonas gingivalis ATCC 33277  PGN_0147  WP_012457279.1  B2RH21  775 aa hypothetical protein 0.0065 ●○○○○ -0.04 -0.0381512386450404
Escherichia coli M12  CO715_15840  ATI08832.1  609 aa DNA helicase RecQ 8.1e-30 ●○○○○ -0.04 -0.0378830633645764
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2447  AIK81044.1  482 aa hypothetical protein 3.1e-9 ●○○○○ -0.04 -0.0377365236109622
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3973  AIK82521.1  356 aa dihydroxyacetone kinase, DhaK subunit <1e-323 ●○○○○ -0.04 -0.0377212178234582
Escherichia coli M12  CO715_11675  ATI06305.1  946 aa glutamine-synthetase adenylyltransferase 5.5e-11 ●○○○○ -0.04 -0.0376744173503276
Escherichia coli M12  CO715_22210  ATI08206.1  355 aa dTDP-glucose 4,6-dehydratase 7.3e-6 ●○○○○ -0.04 -0.0374657713360787
Escherichia coli M12  CO715_04900  ATI05129.1  547 aa multidrug ABC transporter permease/ATP-binding protein 4.6e-39 ●○○○○ -0.04 -0.0370484793075809
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_1459  AIK80080.1  495 aa gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase 1.6e-5 ●○○○○ -0.04 -0.0365552783671987
Vibrio cholerae O1 biovar El Tor str. N16961  VC_1386  NP_231030.1  Q9KS73  450 aa chaperone 0.0013 ●○○○○ -0.04 -0.0365522395415162
Porphyromonas gingivalis ATCC 33277  PGN_0448  WP_005875129.1  B2RHX2  219 aa ABC transporter ATP-binding protein <1e-323 ●○○○○ -0.04 -0.0365175094217173
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0792  NP_230441.1  Q9KTU5  oadB  433 aa oxaloacetate decarboxylase subunit beta 0.0023 ●○○○○ -0.04 -0.0363709367021287
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3904  AIK82452.1  314 aa tRNA pseudouridine(55) synthase 3.2e-13 ●○○○○ -0.04 -0.0361153310666752
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3102  AIK81683.1  256 aa thiazole biosynthesis ThiG family protein 0.0028 ●○○○○ -0.03 -0.0348327378039716
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0344  NP_229998.1  Q9KV14  581 aa N-acetylmuramoyl-L-alanine amidase 0.0056 ●○○○○ -0.03 -0.0346479710224268
Escherichia coli M12  CO715_04005  ATI04977.1  252 aa phosphoglycolate phosphatase 7.9e-10 ●○○○○ -0.03 -0.0335014970653503
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A0253  NP_232651.1  Q9KMR7  232 aa antibiotic acetyltransferase 0.012 ●○○○○ -0.03 -0.0333762843298299
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A0573  NP_232963.1  Q9KM16  195 aa DamX-like protein 0.003 ●○○○○ -0.03 -0.0321395491778487
Vibrio cholerae O1 biovar El Tor str. N16961  VC_1150  NP_230795.2  Q9KSV6  169 aa hypothetical protein 0.0087 ●○○○○ -0.03 -0.0317822516972487
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A0877  NP_233263.1  Q9KL70  358 aa hydrolase 0.00049 ●○○○○ -0.03 -0.0314855558150007
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4260  AIK82804.1  453 aa MFS transporter, sugar porter family protein 1.0e-8 ●○○○○ -0.03 -0.0312511995459907
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3788  AIK82343.1  157 aa hypothetical protein 9.8e-9 ●○○○○ -0.03 -0.0311600969745086
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2237  AIK80842.1  406 aa ABC transporter transmembrane region 2 family protein <1e-323 ●○○○○ -0.03 -0.0307139913312557
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A0590  NP_232980.1  Q9KLZ9  360 aa peptide ABC transporter permease 0.0022 ●○○○○ -0.03 -0.0305035812003325
Porphyromonas gingivalis ATCC 33277  PGN_0531  WP_012457580.1  B2RI55  290 aa DUF58 domain-containing protein 3.3e-13 ●○○○○ -0.03 -0.0304740162242915
Vibrio cholerae O1 biovar El Tor str. N16961  VC_1005  NP_230651.1  Q9KT98  441 aa hypothetical protein 0.00011 ●○○○○ -0.03 -0.0304579816745973
Vibrio cholerae O1 biovar El Tor str. N16961  VC_2472  NP_232101.1  Q9KPA1  323 aa hypothetical protein 0.0016 ●○○○○ -0.03 -0.0304370540742509
Vibrio cholerae O1 biovar El Tor str. N16961  VC_1423  NP_231066.1  Q9KS38  244 aa hypothetical protein 0.021 ●○○○○ -0.03 -0.030259427775554
Vibrio cholerae O1 biovar El Tor str. N16961  VC_2417  NP_232047.2  Q9KPF1  579 aa ssDNA exonuclease RecJ 0.01 ●○○○○ -0.03 -0.0298147422324286
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3404  AIK81961.1  337 aa 2-aminoethylphosphonate ABC transporter, 2-aminoethylphosphonate binding protein 0.0002 ●○○○○ -0.03 -0.0295749119014405
Vibrio cholerae O1 biovar El Tor str. N16961  VC_2540  NP_232168.1  Q9KP39  130 aa hypothetical protein 0.0015 ●○○○○ -0.03 -0.0291999850091799
Escherichia coli M12  CO715_01140  ATI04460.1  498 aa ATPase RavA 4.6e-6 ●○○○○ -0.03 -0.0291199307661243
Escherichia coli M12  CO715_18495  ATI07531.1  325 aa protein CsiD 2.0e-6 ●○○○○ -0.03 -0.0287026387376265
Vibrio cholerae O1 biovar El Tor str. N16961  VC_2481  NP_232110.1  Q9KP92  409 aa D-3-phosphoglycerate dehydrogenase 5.7e-7 ●○○○○ -0.03 -0.0286730708804627
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2068  AIK80673.1  99 aa hypothetical protein 3.4e-5 ●○○○○ -0.03 -0.0284846222723155
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3291  AIK81852.1  286 aa yihY family inner membrane domain protein <1e-323 ●○○○○ -0.03 -0.0280314686907477
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2848  AIK81437.1  577 aa outer membrane protein <1e-323 ●○○○○ -0.03 -0.0278232137461045
Vibrio cholerae O1 biovar El Tor str. N16961  VC_2316  NP_231947.1  Q9KPQ0  argA  456 aa N-acetylglutamate synthase 0.0045 ●○○○○ -0.03 -0.0276233168814646
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2503  AIK81100.1  394 aa yabM MFS transporter 2.2e-16 ●○○○○ -0.03 -0.0274687322384768
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A0114  NP_232515.1  Q9KN51  444 aa hypothetical protein 0.029 ●○○○○ -0.03 -0.0270904429104601
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0291  NP_229946.1  Q9KV66  dusB  331 aa NifR3/Smm1 family protein 0.01 ●○○○○ -0.03 -0.0267747423900349
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A0545  NP_232935.1  Q9KM44  580 aa 5`-nucleotidase 0.048 ●○○○○ -0.03 -0.0262426124732344
Escherichia coli M12  CO715_11375  ATI06252.1  427 aa hypothetical protein 0.0015 ●○○○○ -0.03 -0.0259902405523913
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4535  AIK83073.1  845 aa type VII secretion system (T7SS), usher family protein <1e-323 ●○○○○ -0.03 -0.0257811736798291
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0683  NP_230332.1  Q9KU46  lspA  171 aa lipoprotein signal peptidase 0.0013 ●○○○○ -0.03 -0.02574427182232
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2974  AIK81559.1  187 aa phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN <1e-323 ●○○○○ -0.03 -0.0250319260835075
Escherichia coli M12  CO715_24525  ATI08596.1  93 aa hypothetical protein 0.00072 ●○○○○ -0.02 -0.024947010481147
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2436  AIK81033.1  39 aa hypothetical protein 0.039 ●○○○○ -0.02 -0.0248876242274035
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4626  AIK83160.1  140 aa SURF4 family protein 0.026 ●○○○○ -0.02 -0.0247460686317799
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A0285  NP_232681.1  Q9KMN9  223 aa hypothetical protein 0.023 ●○○○○ -0.02 -0.024682803641078
Escherichia coli M12  CO715_17280  ATI07316.1  382 aa hypothetical protein 4.9e-5 ●○○○○ -0.02 -0.0245297184526493
Escherichia coli M12  CO715_13325  ATI06603.1  483 aa sodium/panthothenate symporter 3.0e-6 ●○○○○ -0.02 -0.0241124264241516
Escherichia coli M12  CO715_18095  ATI07459.1  714 aa methylmalonyl-CoA mutase 2.2e-8 ●○○○○ -0.02 -0.0236951343956538
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3406  AIK81963.1  286 aa 2-aminoethylphosphonate ABC transporter, permease protein <1e-323 ●○○○○ -0.02 -0.0231345277969789
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2103  AIK80708.1  1115 aa kefA <1e-323 ●○○○○ -0.02 -0.023034800513668
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0452  NP_230106.1  Q9KUR3  353 aa A/G-specific adenine glycosylase 0.048 ●○○○○ -0.02 -0.0229158266600544
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4357  AIK82900.1  472 aa L-fuculokinase <1e-323 ●○○○○ -0.02 -0.0224424400132681
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4938  AIK83464.1  238 aa hypothetical protein 4.1e-5 ●○○○○ -0.02 -0.0222883236493597
Escherichia coli M12  CO715_01965  ATI04605.1  940 aa excinuclease ABC subunit A 1.7e-24 ●○○○○ -0.02 -0.0222346122959119
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0063  NP_229722.1  Q9KVS6  258 aa thiazole biosynthesis adenylyltransferase ThiF 0.036 ●○○○○ -0.02 -0.0217278084083328
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2434  AIK81031.1  220 aa carbonic anhydrase 2 <1e-323 ●○○○○ -0.02 -0.0216484460471514
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3473  AIK82029.1  558 aa DNA ligase <1e-323 ●○○○○ -0.02 -0.0215602583651655
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A0832  NP_233218.1  Q9KLB4  210 aa methyltransferase 0.03 ●○○○○ -0.02 -0.0211326869830345
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0437  NP_230091.2  Q9KUS8  cgtA  390 aa GTPase ObgE 0.028 ●○○○○ -0.02 -0.0204606946057776
Vibrio cholerae O1 biovar El Tor str. N16961  VC_1917  NP_231551.1  Q9KQT1  103 aa hypothetical protein 0.015 ●○○○○ -0.02 -0.0203606977222001
Vibrio cholerae O1 biovar El Tor str. N16961  VC_1603  NP_231243.1  Q9KRN3  258 aa hypothetical protein 0.0092 ●○○○○ -0.02 -0.0202905243193362
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0019  NP_229678.1  Q9KVW9  418 aa valine--pyruvate transaminase 0.00091 ●○○○○ -0.02 -0.019680804223144
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3321  AIK81878.1  622 aa potassium uptake protein <1e-323 ●○○○○ -0.02 -0.0187401417738499
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3927  AIK82475.1  443 aa D-galactonate transporter family protein <1e-323 ●○○○○ -0.02 -0.0183846665034409
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_1664  AIK80284.1  513 aa bacterial extracellular solute-binding, 5 Middlefamily protein 0.0021 ●○○○○ -0.02 -0.0183097205619778
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2457  AIK81054.1  316 aa alpha-N-arabinofuranosidase 2 <1e-323 ●○○○○ -0.02 -0.0180929083335498
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A1018  NP_233402.1  Q9KKT2  452 aa ada regulatory protein 0.00096 ●○○○○ -0.02 -0.0180813976691616
Escherichia coli M12  CO715_01670  ATI04552.1  445 aa arginine:agmatine antiporter 0.029 ●○○○○ -0.02 -0.0176443999824369
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0530  NP_230181.1  Q9KUJ0  truD  361 aa tRNA pseudouridine synthase D 0.014 ●○○○○ -0.02 -0.0175656582160067
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2656  AIK81250.1  265 aa 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase 0.00051 ●○○○○ -0.02 -0.0167644709142078
Escherichia coli M12  CO715_04590  ATI05078.1  137 aa 5-hydroxyisourate hydrolase 0.0074 ●○○○○ -0.02 -0.0166011699111926
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4303  AIK82848.1  404 aa acetate kinase 7.8e-6 ●○○○○ -0.02 -0.0164475719883965
Escherichia coli M12  CO715_02095  ATI04629.1  396 aa maltose/maltodextrin ABC transporter substrate-binding protein MalE 0.02 ●○○○○ -0.02 -0.0163925238969437
Porphyromonas gingivalis ATCC 33277  PGN_1939  WP_004583644.1  B2RM63  dtd  150 aa D-tyrosyl-tRNA(Tyr) deacylase 0.00072 ●○○○○ -0.02 -0.0153831697976813
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A0255  NP_232653.1  Q9KMR5  276 aa hypothetical protein 0.026 ●○○○○ -0.02 -0.0152018389515774
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4302  AIK82847.1  300 aa GHMP kinase N terminal domain protein 1.5e-6 ●○○○○ -0.02 -0.0151612189095803
Vibrio cholerae O1 biovar El Tor str. N16961  VC_1965  NP_231599.1  Q9KQN3  196 aa hypothetical protein 0.00023 ●○○○○ -0.01 -0.0149200629663142
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