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Sorted by significance (p<0.05) and Fitness z-Scores (highest impact first):

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Pathogen Locus Protein UniProt Gene Length Product p-Value Fitness z-Score  Precise fitness z-Score
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2745  AIK81335.1  161 aa hypothetical protein 0.017 ●○○○○ -0.07 -0.0712182044657284
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2191  AIK80796.1  294 aa nucleoside-specific channel-forming, Tsx familyprotein <1e-323 ●○○○○ -0.07 -0.0711474655886627
Escherichia coli M12  CO715_11935  ATI06354.1  95 aa hypothetical protein 7.4e-13 ●○○○○ -0.07 -0.0708491336158965
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_1974  AIK80580.1  555 aa bacterial extracellular solute-binding, 5 Middlefamily protein 0.00036 ●○○○○ -0.07 -0.0704679593399888
Escherichia coli M12  CO715_17180  ATI07297.1  899 aa CRISPR-associated helicase/endonuclease Cas3 1.3e-24 ●○○○○ -0.07 -0.0704318415873988
Escherichia coli M12  CO715_15185  ATI06939.1  79 aa hypothetical protein 0.021 ●○○○○ -0.07 -0.070014549558901
Vibrio cholerae O1 biovar El Tor str. N16961  VC_1820  NP_231454.1  Q9KR27  146 aa PTS system fructose-specific transporter subunit IIA 0.0026 ●○○○○ -0.07 -0.0696705512389637
Escherichia coli M12  CO715_12685  ATI06486.1  259 aa PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC 9.6e-8 ●○○○○ -0.07 -0.0687626734734079
Escherichia coli M12  CO715_17770  ATI07404.1  381 aa YopN family type III secretion system gatekeeper subunit 1.7e-70 ●○○○○ -0.07 -0.0677194434021636
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4892  AIK83419.1  544 aa malate dehydrogenase 3.4e-11 ●○○○○ -0.07 -0.0667633642703184
Vibrio cholerae O1 biovar El Tor str. N16961  VC_2516  NP_232145.1  Q9KP60  109 aa anti-sigma B factor antagonist 0.0033 ●○○○○ -0.07 -0.0667122119633333
Escherichia coli M12  CO715_22985  ATI08338.1  390 aa isoaspartyl dipeptidase 1.8e-15 ●○○○○ -0.07 -0.0664675673166704
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3238  AIK81799.1  302 aa bacterial regulatory helix-turn-helix, lysR family protein <1e-323 ●○○○○ -0.07 -0.0662068893613875
Porphyromonas gingivalis ATCC 33277  PGN_1037  WP_012457976.1  B2RJL1  150 aa hypothetical protein <1e-323 ●○○○○ -0.07 -0.0654149598059854
Vibrio cholerae O1 biovar El Tor str. N16961  VC_1651  NP_231288.1  Q9KRI9  553 aa response regulator VieB 4.5e-5 ●○○○○ -0.07 -0.0652101883301686
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2871  AIK81460.1  397 aa sugar (and other) transporter family protein 0.0059 ●○○○○ -0.06 -0.0649947968548307
Escherichia coli M12  CO715_12170  ATI06398.1  392 aa type II secretion system protein GspL 2.0e-13 ●○○○○ -0.06 -0.0641724611599329
Vibrio cholerae O1 biovar El Tor str. N16961  VC_1325  NP_230969.1  Q9KSD3  324 aa galactoside ABC transporter periplasmic D-galactose/D-glucose-binding protein 0.027 ●○○○○ -0.06 -0.0636852375779627
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0204  NP_229861.1  Q9KVE2  282 aa hypothetical protein 0.017 ●○○○○ -0.06 -0.063415257657478
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2427  AIK81024.1  263 aa 3-methyl-2-oxobutanoate hydroxymethyltransferase 0.001 ●○○○○ -0.06 -0.0632301694823564
Escherichia coli M12  CO715_08420  ATI05733.1  600 aa hypothetical protein 2.9e-20 ●○○○○ -0.06 -0.0631292310886886
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3623  AIK82178.1  379 aa UDP-L-Ara4O C-4' transaminase 1.8e-9 ●○○○○ -0.06 -0.0628648482876334
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4856  AIK83383.1  321 aa o-succinylbenzoate synthase 3.2e-5 ●○○○○ -0.06 -0.0623356734397109
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3378  AIK81934.1  553 aa aspT/YidE/YbjL antiporter duplication domain protein 3.6e-10 ●○○○○ -0.06 -0.0622908221935512
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A0835  NP_233221.1  Q9KLB1  328 aa hypothetical protein 0.00018 ●○○○○ -0.06 -0.0614143630691581
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_1737  AIK80357.1  241 aa histidine utilization repressor 0.034 ●○○○○ -0.06 -0.0612230629521986
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4281  AIK82826.1  346 aa aldo/keto reductase family protein 4.4e-5 ●○○○○ -0.06 -0.0609277512653605
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2242  AIK80847.1  283 aa tauD <1e-323 ●○○○○ -0.06 -0.0608837352943099
Porphyromonas gingivalis ATCC 33277  PGN_0715  WP_012457722.1  B2RIN9  444 aa TolC family protein <1e-323 ●○○○○ -0.06 -0.0604066746536994
Escherichia coli M12  CO715_19775  ATI07758.1  624 aa molecular chaperone HtpG 0.009 ●○○○○ -0.06 -0.0602081868892046
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2943  AIK81528.1  324 aa hypothetical protein <1e-323 ●○○○○ -0.06 -0.0599626157266952
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0455  NP_230109.1  Q9KUR0  391 aa coproporphyrinogen III oxidase 0.0064 ●○○○○ -0.06 -0.0598114102638233
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2310  AIK80914.1  482 aa succinate-semialdehyde dehydrogenase family protein <1e-323 ●○○○○ -0.06 -0.0597088223497702
Escherichia coli M12  CO715_00110  ATI04277.1  384 aa bifunctional tRNA (adenosine(37)-C2)-methyltransferase TrmG/ribosomal RNA large subunit methyltransferase RlmN 5.7e-8 ●○○○○ -0.06 -0.059582248846458
Escherichia coli M12  CO715_23180  ATI08371.1  143 aa PTS sugar transporter subunit IIA 4.6e-7 ●○○○○ -0.06 -0.059582248846458
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2925  AIK81511.1  180 aa fimbrial family protein 0.0028 ●○○○○ -0.06 -0.0594886286599438
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3528  AIK82084.1  635 aa mtlA <1e-323 ●○○○○ -0.06 -0.0593834211201144
Escherichia coli M12  CO715_14790  ATI06869.1  356 aa sn-glycerol-3-phosphate import ATP-binding protein UgpC 0.017 ●○○○○ -0.06 -0.0593736028322091
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3738  AIK82293.1  601 aa proton antiporter-2 family protein <1e-323 ●○○○○ -0.06 -0.0590349260927847
Escherichia coli M12  CO715_12455  ATI06445.1  321 aa hypothetical protein 6.6e-6 ●○○○○ -0.06 -0.0587476647894625
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0595  NP_230245.1  Q9KUC7  gluQ  304 aa glutamyl-Q tRNA(Asp) synthetase 0.012 ●○○○○ -0.06 -0.0585686533289092
Vibrio cholerae O1 biovar El Tor str. N16961  VC_1994  NP_231628.1  Q9KQK4  616 aa endopeptidase IV 0.0014 ●○○○○ -0.06 -0.0581694085581852
Escherichia coli M12  CO715_04600  ATI05079.1  452 aa two-component sensor histidine kinase 7.2e-20 ●○○○○ -0.06 -0.0581217267467159
Vibrio cholerae O1 biovar El Tor str. N16961  VC_1740  NP_231376.1  Q9KRA2  760 aa acyl-CoA dehydrogenase 0.011 ●○○○○ -0.06 -0.0581035218706196
Vibrio cholerae O1 biovar El Tor str. N16961  VC_2660  NP_232288.1  Q9KNS1  efp  188 aa elongation factor P 5.1e-5 ●○○○○ -0.06 -0.0571448100382366
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4977  AIK83503.1  350 aa fructose bisphosphate aldolase 0.0045 ●○○○○ -0.06 -0.0570935026569861
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A0854  NP_233240.1  Q9KL92  419 aa hypothetical protein 0.012 ●○○○○ -0.06 -0.0569464145077661
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0896  NP_230543.1  Q9KTK6  306 aa DNA-binding transcriptional activator GcvA 0.0014 ●○○○○ -0.06 -0.056814004926826
Escherichia coli M12  CO715_09040  ATI05850.1  348 aa galactose-1-phosphate uridylyltransferase 0.0014 ●○○○○ -0.06 -0.056452558632725
Escherichia coli M12  CO715_13960  ATI06713.1  235 aa tRNA (N6-threonylcarbamoyladenosine(37)-N6)-methyltransferase TrmO 0.038 ●○○○○ -0.06 -0.056452558632725
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3855  AIK82405.1  427 aa sugar (and other) transporter family protein <1e-323 ●○○○○ -0.06 -0.0556400086940039
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3417  AIK81974.1  237 aa 4-carboxy-4-hydroxy-2-oxoadipate aldolase/oxaloacetate decarboxylase <1e-323 ●○○○○ -0.06 -0.0553263668864108
Escherichia coli M12  CO715_18895  ATI07601.1  205 aa glutathione S-transferase family protein 2.1e-14 ●○○○○ -0.05 -0.0547833905187341
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3273  AIK81834.1  421 aa lacY lactose MFS transporter <1e-323 ●○○○○ -0.05 -0.0545477714720238
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3684  AIK82239.1  754 aa glycogen/starch/alpha-glucan phosphorylases family protein <1e-323 ●○○○○ -0.05 -0.0545439956407039
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0803  NP_230452.1  Q9KTT5  257 aa RNA methyltransferase 0.016 ●○○○○ -0.05 -0.0543757355733679
Escherichia coli M12  CO715_01260  ATI04480.1  354 aa L-ascorbate-6-phosphate lactonase 3.5e-13 ●○○○○ -0.05 -0.0543660984902365
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4732  AIK83266.1  299 aa coproporphyrinogen III oxidase family protein <1e-323 ●○○○○ -0.05 -0.0541446441235979
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4348  AIK82891.1  273 aa hypothetical protein <1e-323 ●○○○○ -0.05 -0.0540654630280018
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_1709  AIK80329.1  579 aa heme ABC exporter, ATP-binding protein CcmA 0.0031 ●○○○○ -0.05 -0.052826710301294
Escherichia coli M12  CO715_07270  ATI05534.1  342 aa TMAO reductase system periplasmic protein TorT 0.0002 ●○○○○ -0.05 -0.0526969303762456
Vibrio cholerae O1 biovar El Tor str. N16961  VC_2340  NP_231970.1  Q9KPM7  384 aa hypothetical protein 3.6e-5 ●○○○○ -0.05 -0.0523648556690391
Vibrio cholerae O1 biovar El Tor str. N16961  VC_1635  NP_231272.1  Q9KRK5  rsuA  231 aa 16S rRNA pseudouridine(516) synthase 0.0015 ●○○○○ -0.05 -0.0522618755549684
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A0684  NP_233072.1  Q9KLQ8  436 aa regulatory protein UhpC 0.00046 ●○○○○ -0.05 -0.0519807873660136
Escherichia coli M12  CO715_16930  ATI07252.1  746 aa carbamoyltransferase HypF 4.5e-10 ●○○○○ -0.05 -0.0518623463192501
Escherichia coli M12  CO715_17675  ATI07387.1  210 aa LuxR family transcriptional regulator 1.3e-13 ●○○○○ -0.05 -0.0512364082765035
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3022  AIK81607.1  752 aa tonB-dependent siderophore receptor family protein <1e-323 ●○○○○ -0.05 -0.0511230582197472
Vibrio cholerae O1 biovar El Tor str. N16961  VC_1408  NP_231051.1  Q9KS52  200 aa TetR family transcriptional regulator 0.0019 ●○○○○ -0.05 -0.0509570560092815
Escherichia coli M12  CO715_06220  ATI05350.1  187 aa fimbrial protein 1.6e-17 ●○○○○ -0.05 -0.0508191162480058
Escherichia coli M12  CO715_22840  ATI08312.1  763 aa phosphatidylglycerol--membrane-oligosaccharide glycerophosphotransferase 1.6e-15 ●○○○○ -0.05 -0.0508191162480058
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4937  AIK83463.1  336 aa branched-chain amino acid transport system / permease component family protein <1e-323 ●○○○○ -0.05 -0.0491779611060868
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A0988  NP_233372.1  Q9KKW2  518 aa methyl-accepting chemotaxis protein 0.0084 ●○○○○ -0.05 -0.0485148928481207
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3371  AIK81928.1  408 aa hypothetical protein 6.7e-7 ●○○○○ -0.05 -0.0484107840014198
Escherichia coli M12  CO715_21780  ATI08127.1  272 aa hypothetical protein 2.2e-5 ●○○○○ -0.05 -0.0481067180627706
Escherichia coli M12  CO715_10475  ATI06085.1  457 aa MFS transporter 3.6e-64 ●○○○○ -0.05 -0.0476894260342729
Escherichia coli M12  CO715_15255  ATI06951.1  199 aa glucose-1-phosphatase 8.8e-8 ●○○○○ -0.05 -0.0476894260342729
Escherichia coli M12  CO715_01700  ATI04557.1  292 aa hypothetical protein 2.0e-5 ●○○○○ -0.05 -0.0474807800200241
Escherichia coli M12  CO715_21115  ATI08007.1  419 aa anaerobic glycerol-3-phosphate dehydrogenase subunit B 0.019 ●○○○○ -0.05 -0.0474807800200241
Escherichia coli CFT073  c1996  AAN80456.1  A0A0H2V9S5  ydgH  314 aa Protein ydgH precursor 0.033 ●○○○○ -0.05 -0.0473473145521664
Escherichia coli M12  CO715_01200  ATI04468.1  264 aa DUF2686 domain-containing protein 3.7e-39 ●○○○○ -0.05 -0.0464375499487797
Escherichia coli M12  CO715_17355  ATI07329.1  282 aa NADPH-dependent 7-cyano-7-deazaguanine reductase QueF 9.0e-17 ●○○○○ -0.05 -0.0464375499487797
Vibrio cholerae O1 biovar El Tor str. N16961  VC_2379  NP_232009.1  Q9KPI8  mtnN  231 aa 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 1.2e-5 ●○○○○ -0.05 -0.0462011667295828
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_1997  AIK80603.1  326 aa alanine racemase 6.2e-5 ●○○○○ -0.05 -0.0460359956188738
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2015  AIK80621.1  395 aa anaerobic sulfatase maturase 1.2e-5 ●○○○○ -0.05 -0.0459859629622049
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A0364  NP_232759.1  Q9K2P2  88 aa hypothetical protein 0.0051 ●○○○○ -0.05 -0.0459354997997473
Escherichia coli M12  CO715_09230  ATI05877.1  105 aa DUF4387 domain-containing protein 4.1e-10 ●○○○○ -0.05 -0.0458116119060332
Vibrio cholerae O1 biovar El Tor str. N16961  VC_2287  NP_231918.1  Q9KPS5  dinB  360 aa DNA polymerase IV 0.0015 ●○○○○ -0.05 -0.0453497866659506
Vibrio cholerae O1 biovar El Tor str. N16961  VC_1786  NP_231421.1  Q9KR57  158 aa DNA repair protein RadC 0.00074 ●○○○○ -0.05 -0.0450835551410387
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2807  AIK81396.1  311 aa aspartate carbamoyltransferase 0.00034 ●○○○○ -0.05 -0.0450686936067384
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3814  AIK82364.1  202 aa conserved inner membrane protein 1.4e-8 ●○○○○ -0.04 -0.0449394469929967
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2689  AIK81283.1  335 aa tryptophan--tRNA ligase 0.00037 ●○○○○ -0.04 -0.0447187403654554
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0026  NP_229685.1  Q9KVW2  326 aa zinc-binding alcohol dehydrogenase 0.0092 ●○○○○ -0.04 -0.0445148268824473
Porphyromonas gingivalis ATCC 33277  PGN_1039  WP_039417211.1  B2RJL3  741 aa alpha-mannosidase <1e-323 ●○○○○ -0.04 -0.044441052239861
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A0241  NP_232639.1  Q9KMS9  294 aa L-xylulose 5-phosphate 3-epimerase 0.012 ●○○○○ -0.04 -0.0443810885854261
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2790  AIK81379.1  500 aa putative ATPase 8.2e-10 ●○○○○ -0.04 -0.0442058182296828
Escherichia coli M12  CO715_14550  ATI06823.1  314 aa nickel ABC transporter permease subunit NikB 0.044 ●○○○○ -0.04 -0.0441424437920423
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3956  AIK82504.1  235 aa B3/4 domain protein 1.2e-11 ●○○○○ -0.04 -0.0438953564498802
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3568  AIK82123.1  526 aa dppA <1e-323 ●○○○○ -0.04 -0.0438274192855628
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0262  NP_229918.1  Q9KV94  323 aa UDP-glucose 4-epimerase 0.0014 ●○○○○ -0.04 -0.043619896989159
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_1761  AIK80381.1  262 aa molybdenum-pterin binding domain protein 1.2e-15 ●○○○○ -0.04 -0.0434687229622021
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