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Sorted by significance (p<0.05) and Fitness z-Scores (highest impact first):

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Pathogen Locus Protein UniProt Gene Length Product p-Value Fitness z-Score  Precise fitness z-Score
Acinetobacter baumannii ATCC 17978  A1S_1399  ABO11827.2  286 aa ArtI protein 0.0064 ●○○○○ -0.75 -0.745249700372721
Vibrio cholerae O1 biovar El Tor str. N16961  VC_2455  NP_232084.1  Q9KPB8  136 aa hypothetical protein 4.0e-6 ●○○○○ -0.74 -0.744773593317981
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4258  AIK82803.1  253 aa 2-deoxy-D-gluconate 3-dehydrogenase 0.0027 ●○○○○ -0.74 -0.744416796233088
Escherichia coli M12  CO715_03560  ATI04896.1  215 aa thiol:disulfide oxidoreductase 5.7e-9 ●○○○○ -0.74 -0.744358467611221
Escherichia coli M12  CO715_11155  ATI06210.1  191 aa protein Ves 2.5e-7 ●○○○○ -0.74 -0.744149821596972
Porphyromonas gingivalis ATCC 33277  PGN_0139  WP_012457274.1  B2RH13  rlmH  157 aa 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH <1e-323 ●○○○○ -0.74 -0.744098836720695
Salmonella enterica Serovar Typhimurium ST4 74  STM474_4461  WP_000412686.1  E8X9R6  soxR  152 aa redox-sensitive transcriptional activator SoxR 0.0021 ●○○○○ -0.74 -0.744063039318187
Porphyromonas gingivalis ATCC 33277  PGN_0390  WP_012457473.1  B2RHR4  287 aa hypothetical protein <1e-323 ●○○○○ -0.74 -0.743792402555984
Porphyromonas gingivalis ATCC 33277  PGN_1690  WP_012458461.1  B2RLG4  606 aa alpha-1,3/4-fucosidase 0.029 ●○○○○ -0.74 -0.743454155667094
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3832  WP_000275326.1  E8XFX4  xylB  484 aa xylulokinase 0.0014 ●○○○○ -0.74 -0.743407108991063
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0350  NP_230004.1  Q9KV08  hflC  326 aa HflC protein 0.00062 ●○○○○ -0.74 -0.743290642408326
Porphyromonas gingivalis ATCC 33277  PGN_0224  WP_012457343.1  B2RH98  402 aa UDP-N-acetyl-D-mannosamine dehydrogenase 9.2e-15 ●○○○○ -0.74 -0.743263839828629
Porphyromonas gingivalis ATCC 33277  PGN_0490  WP_039416938.1  B2RI14  444 aa MATE family efflux transporter 0.00064 ●○○○○ -0.74 -0.742798465719691
Porphyromonas gingivalis ATCC 33277  PGN_0013  WP_012457170.1  B2RGN7  445 aa GHKL domain-containing protein 1.8e-11 ●○○○○ -0.74 -0.742608020885985
Porphyromonas gingivalis ATCC 33277  PGN_1444  WP_012458274.1  B2RKR8  carA  357 aa glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit <1e-323 ●○○○○ -0.74 -0.742438705122606
Vibrio cholerae O1 biovar El Tor str. N16961  VC_1047  NP_230692.2  Q9KT58  fadJ  708 aa multifunctional fatty acid oxidation complex subunit alpha 0.00015 ●○○○○ -0.74 -0.742327640103496
Escherichia coli M12  CO715_01480  ATI04518.1  48 aa entericidin B 3.1e-17 ●○○○○ -0.74 -0.741228777397488
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3965  AIK82513.1  295 aa deoC/LacD aldolase family protein <1e-323 ●○○○○ -0.74 -0.741027498627017
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0718  NP_230367.1  Q9KU12  rdgC  304 aa recombination associated protein 8.0e-8 ●○○○○ -0.74 -0.739955075103765
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2262  AIK80867.1  224 aa gram-negative pili assembly chaperone, N-terminal domain protein 1.1e-14 ●○○○○ -0.74 -0.739118251601388
Porphyromonas gingivalis ATCC 33277  PGN_0689  WP_004585199.1  B2RIL3  127 aa DUF3276 family protein 0.0003 ●○○○○ -0.74 -0.738089852968737
Vibrio cholerae O1 biovar El Tor str. N16961  VC_1543  NP_231183.1  Q9KRU1  392 aa hypothetical protein 4.5e-5 ●○○○○ -0.74 -0.738049764404933
Escherichia coli M12  CO715_15435  ATI06983.1  199 aa DUF1454 domain-containing protein 2.7e-5 ●○○○○ -0.74 -0.737890441169506
Escherichia coli M12  CO715_12385  ATI06432.1  327 aa transcriptional regulator EbgR 8.8e-6 ●○○○○ -0.74 -0.737681795155257
Vibrio cholerae O1 biovar El Tor str. N16961  VC_2039  NP_231673.1  Q9KQF9  333 aa nucleoid-associated protein NdpA 4.2e-6 ●○○○○ -0.74 -0.736982834809045
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A0195  NP_232595.1  Q9KMX1  182 aa hypothetical protein 1.8e-8 ●○○○○ -0.74 -0.736508667654126
Salmonella enterica Serovar Typhimurium ST4 74  STM474_2439  WP_001522266.1  E8XEZ5  ulaA  463 aa PTS ascorbate transporter subunit IIC 0.0006 ●○○○○ -0.74 -0.736376421149716
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3353  AIK81910.1  191 aa putative phosphopantetheinyl transferase 9.9e-9 ●○○○○ -0.73 -0.734737459222378
Salmonella enterica Serovar Typhimurium ST4 74  STM474_1951  WP_000204362.1  E8XA66  cheR  288 aa protein-glutamate O-methyltransferase CheR 0.019 ●○○○○ -0.73 -0.733917642506094
Acinetobacter baumannii ATCC 17978  A1S_1309  ABO11737.2  454 aa hypothetical protein 8.6e-6 ●○○○○ -0.73 -0.733859079440189
Porphyromonas gingivalis ATCC 33277  PGN_0156  WP_012457286.1  B2RH30  227 aa PorT family protein <1e-323 ●○○○○ -0.73 -0.733833493129823
Escherichia coli M12  CO715_14880  ATI06884.1  91 aa hypothetical protein 6.1e-7 ●○○○○ -0.73 -0.733717520884529
Salmonella enterica Serovar Typhimurium ST4 74  STM474_1446  WP_000250717.1  E8XHD2  ydhF  298 aa aldo/keto reductase family oxidoreductase 0.0021 ●○○○○ -0.73 -0.733553404507458
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A0949  NP_233333.1  Q9KL01  205 aa SM-20-like protein 0.018 ●○○○○ -0.73 -0.733465184148583
Acinetobacter baumannii ATCC 17978  A1S_2905  ABO13311.2  916 aa glutamine synthetase adenylyltransferase 3.0e-6 ●○○○○ -0.73 -0.73310847299016
Acinetobacter baumannii ATCC 17978  A1S_2542  ABO12959.2  223 aa hypothetical protein 4.8e-6 ●○○○○ -0.73 -0.732927513433562
Escherichia coli M12  CO715_02840  ATI04767.1  233 aa ethanolamine utilization acetate kinase EutQ 0.00088 ●○○○○ -0.73 -0.732465644799036
Escherichia coli M12  CO715_18185  ATI07476.1  225 aa ABC transporter ATP-binding protein 0.0056 ●○○○○ -0.73 -0.731422414727791
Escherichia coli M12  CO715_18610  ATI07551.1  326 aa PTS sorbitol transporter subunit IIB 8.3e-20 ●○○○○ -0.73 -0.730796476685045
Salmonella enterica Serovar Typhimurium ST4 74  STM474_4264  WP_000802242.1  E8XKE9  yiiQ  198 aa DUF1454 family protein 0.0031 ●○○○○ -0.73 -0.730349407159915
Escherichia coli M12  CO715_15505  ATI06994.1  176 aa HslU--HslV peptidase proteolytic subunit 0.00018 ●○○○○ -0.73 -0.729544600599552
Escherichia coli M12  CO715_04275  ATI05030.1  377 aa 2-iminoacetate synthase ThiH 0.00054 ●○○○○ -0.73 -0.729127308571054
Escherichia coli M12  CO715_21680  ATI08108.1  378 aa VWA domain-containing protein 0.0031 ●○○○○ -0.73 -0.728710016542556
Porphyromonas gingivalis ATCC 33277  PGN_0672  WP_005874528.1  B2RIJ6  244 aa MotA/TolQ/ExbB proton channel family protein <1e-323 ●○○○○ -0.73 -0.728624810518449
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3403  AIK81960.1  239 aa transcriptional regulator protein <1e-323 ●○○○○ -0.73 -0.727821743722681
Porphyromonas gingivalis ATCC 33277  PGN_0120  WP_012457260.1  B2RGZ4  160 aa TlpA family protein disulfide reductase <1e-323 ●○○○○ -0.73 -0.727556058123983
Porphyromonas gingivalis ATCC 33277  PGN_0373  WP_012457458.1  B2RHP7  169 aa redoxin domain-containing protein <1e-323 ●○○○○ -0.73 -0.727244340200758
Porphyromonas gingivalis ATCC 33277  PGN_1638  WP_012458426.1  B2RLB2  497 aa histidine ammonia-lyase 0.0024 ●○○○○ -0.73 -0.727013174155174
Escherichia coli M12  CO715_10855  ATI06153.1  1018 aa FAD-binding oxidoreductase 1.3e-15 ●○○○○ -0.73 -0.72620626437157
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2280  AIK80885.1  367 aa proB 2.7e-12 ●○○○○ -0.73 -0.725213715797225
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3949  WP_001270489.1  E8XGX3  460 aa glycoside hydrolase family 1 protein 0.0085 ●○○○○ -0.73 -0.725073283829434
Salmonella enterica Serovar Typhimurium ST4 74  STM474_1357  WP_001278565.1  E8XGF9  ydis  428 aa FAD-dependent oxidoreductase 0.00098 ●○○○○ -0.72 -0.724826483142811
Acinetobacter baumannii ATCC 17978  A1S_2563  ABO12980.1  201 aa putative siderophore-interacting protein 0.0078 ●○○○○ -0.72 -0.724666223603727
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0088  NP_229747.1  Q9KVQ3  tatC  250 aa hypothetical protein 1.7e-6 ●○○○○ -0.72 -0.724473128054678
Porphyromonas gingivalis ATCC 33277  PGN_0447  WP_012457513.1  B2RHX1  424 aa ABC transporter permease <1e-323 ●○○○○ -0.72 -0.724369658183305
Salmonella enterica Serovar Typhimurium ST4 74  STM474_0324  WP_000973041.1  E8XJL2  fadE  814 aa acyl-CoA dehydrogenase 0.0012 ●○○○○ -0.72 -0.724153879697209
Porphyromonas gingivalis ATCC 33277  PGN_0590  WP_043876319.1  B2RIB4  332 aa Fic family protein <1e-323 ●○○○○ -0.72 -0.723512061216595
Escherichia coli M12  CO715_18975  ATI07614.1  264 aa spermidine/putrescine ABC transporter permease 0.0011 ●○○○○ -0.72 -0.723493866186334
Vibrio cholerae O1 biovar El Tor str. N16961  VC_1880  NP_231514.1  Q9KQW7  176 aa hypothetical protein 3.8e-7 ●○○○○ -0.72 -0.72309136833742
Acinetobacter baumannii ATCC 17978  A1S_1200  ABO11630.1  273 aa alkyl hydroperoxide reductase subunit F 0.013 ●○○○○ -0.72 -0.72278624162038
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A0890  NP_233275.1  Q9KL58  127 aa glyoxylase I family protein 0.00055 ●○○○○ -0.72 -0.722639482029028
Porphyromonas gingivalis ATCC 33277  PGN_0375  WP_012457459.1  B2RHP9  554 aa nucleoside kinase <1e-323 ●○○○○ -0.72 -0.722491663975551
Porphyromonas gingivalis ATCC 33277  PGN_0168  WP_012457298.1  B2RH42  wbpB  323 aa Gfo/Idh/MocA family oxidoreductase <1e-323 ●○○○○ -0.72 -0.722232344068187
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3881  WP_000645990.1  E8XGQ7  tdh  341 aa L-threonine 3-dehydrogenase 0.00064 ●○○○○ -0.72 -0.722085524458471
Escherichia coli M12  CO715_16740  ATI07219.1  133 aa class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI 0.0001 ●○○○○ -0.72 -0.721824698072344
Escherichia coli M12  CO715_23560  ATI08425.1  364 aa tRNA 2-selenouridine(34) synthase MnmH 5.8e-18 ●○○○○ -0.72 -0.721616052058095
Escherichia coli M12  CO715_23315  ATI08391.1  151 aa hypothetical protein 0.00089 ●○○○○ -0.72 -0.721198760029597
Porphyromonas gingivalis ATCC 33277  PGN_0595  WP_012457630.1  B2RIB9  traM  453 aa conjugative transposon protein TraM <1e-323 ●○○○○ -0.72 -0.720176938676001
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A0381  NP_232775.1  Q9KMH3  59 aa hypothetical protein 0.0025 ●○○○○ -0.72 -0.719675258052874
Acinetobacter baumannii ATCC 17978  A1S_2599  ABO13016.2  106 aa hypothetical protein 0.00015 ●○○○○ -0.72 -0.719128721213214
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A0481  NP_232873.1  Q9K2P7  165 aa hypothetical protein 0.00058 ●○○○○ -0.72 -0.719026662328511
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2705  AIK81295.1  461 aa outer membrane factor of the CusCFBA copper/silver efflux system <1e-323 ●○○○○ -0.72 -0.718990923614531
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A0717  NP_233104.2  Q9KLM6  687 aa DNA helicase IV 1.5e-6 ●○○○○ -0.72 -0.718944415832698
Salmonella enterica Serovar Typhimurium ST4 74  STM474_1823  WP_000197903.1  E8X8H2  dadX  356 aa alanine racemase 0.00072 ●○○○○ -0.72 -0.718924735653777
Escherichia coli M12  CO715_09950  ATI06004.1  372 aa LPS O-antigen length regulator 1.3e-11 ●○○○○ -0.72 -0.718903653872859
Vibrio cholerae O1 biovar El Tor str. N16961  VC_2421  NP_232051.1  Q9KPE7  181 aa N-acetyl-anhydromuranmyl-L-alanine amidase 2.4e-5 ●○○○○ -0.72 -0.71804751827475
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_1994  AIK80600.1  288 aa helix-turn-helix domain protein 1.7e-9 ●○○○○ -0.72 -0.717838676658245
Vibrio cholerae O1 biovar El Tor str. N16961  VC_1990  NP_231624.1  Q9KQK8  646 aa ATP-dependent helicase DinG 9.9e-6 ●○○○○ -0.72 -0.717805451473166
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_1296  AIK79919.1  51 aa hypothetical protein 0.0061 ●○○○○ -0.72 -0.717661394004669
Escherichia coli M12  CO715_16870  ATI07240.1  165 aa nicotinamide-nucleotide amidohydrolase PncC 2.1e-13 ●○○○○ -0.72 -0.716608547716122
Escherichia coli M12  CO715_21690  ATI08110.1  362 aa MoxR family ATPase 1.0e-12 ●○○○○ -0.72 -0.71514802561638
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2859  AIK81448.1  282 aa NAD(P)H:quinone oxidoreductase <1e-323 ●○○○○ -0.72 -0.71507046022692
Porphyromonas gingivalis ATCC 33277  PGN_0148  WP_043876309.1  B2RH22  1596 aa AsmA family protein <1e-323 ●○○○○ -0.71 -0.714872256372902
Escherichia coli M12  CO715_00780  ATI04397.1  497 aa hypothetical protein 2.1e-79 ●○○○○ -0.71 -0.712852919459643
Salmonella enterica Serovar Typhimurium ST4 74  STM474_0282  WP_000806681.1  E8XIT5  300 aa type VI secretion system-associated protein TagK 0.0074 ●○○○○ -0.71 -0.712769768228835
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4000  AIK82547.1  205 aa urease accessory protein UreG <1e-323 ●○○○○ -0.71 -0.712746962657808
Escherichia coli M12  CO715_11960  ATI06359.1  567 aa hydrogenase-2 large chain 7.2e-49 ●○○○○ -0.71 -0.712435627431145
Acinetobacter baumannii ATCC 17978  A1S_0035  ABO10530.2  233 aa putative phosphoglycolate phosphatase 2 (PGP 2) 2.8e-5 ●○○○○ -0.71 -0.711349264690737
Porphyromonas gingivalis ATCC 33277  PGN_0591  WP_012457626.1  B2RIB5  460 aa hypothetical protein 4.8e-9 ●○○○○ -0.71 -0.711239429999928
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A1039  NP_233421.1  Q9KKR3  278 aa amino acid ABC transporter substrate-binding protein 0.0013 ●○○○○ -0.71 -0.711022687240044
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2636  AIK81230.1  453 aa L-galactonate MFS transporter <1e-323 ●○○○○ -0.71 -0.710872179683227
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3294  AIK81855.1  53 aa putative cytoplasmic protein 3.6e-11 ●○○○○ -0.71 -0.710125428055977
Porphyromonas gingivalis ATCC 33277  PGN_1040  WP_004584133.1  B2RJL4  82 aa DUF4492 domain-containing protein <1e-323 ●○○○○ -0.71 -0.708990727358109
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A0513  NP_232904.2  Q9KM75  393 aa aromatic amino acid aminotransferase 0.00019 ●○○○○ -0.71 -0.708459236251268
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2512  AIK81109.1  569 aa L-ribulokinase <1e-323 ●○○○○ -0.71 -0.708303451899647
Vibrio cholerae O1 biovar El Tor str. N16961  VC_1027  NP_230672.1  Q9KT78  81 aa molybdopterin synthase small subunit 1.6e-7 ●○○○○ -0.71 -0.70774930680995
Escherichia coli M12  CO715_24335  ATI08563.1  349 aa type VI secretion system baseplate subunit TssG 1.3e-12 ●○○○○ -0.71 -0.707428123089172
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3966  WP_000998359.1  E8XHM6  438 aa L-fucose:H+ symporter permease 0.016 ●○○○○ -0.71 -0.707075343121227
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3134  AIK81706.1  443 aa proline dipeptidase <1e-323 ●○○○○ -0.71 -0.706962082065097
Escherichia coli M12  CO715_22510  ATI08258.1  300 aa peptide ABC transporter permease 2.4e-10 ●○○○○ -0.71 -0.706593539032177
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