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Sorted by significance (p<0.05) and Fitness z-Scores (highest impact first):

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Pathogen Locus Protein UniProt Gene Length Product p-Value Fitness z-Score  Precise fitness z-Score
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4743  AIK83276.1  303 aa cysteine synthase B 0.00098 ●●○○○ -1.89 -1.8853856296457
Escherichia coli M12  CO715_02765  ATI04754.1  66 aa hypothetical protein 3.8e-14 ●●○○○ -1.88 -1.88419164345275
Escherichia coli O157:H7 str. EDL933  Z0948  AAG55104.1  200 aa unknown protein encoded by prophage CP-933K 0.03 ●●○○○ -1.88 -1.88409667985619
Escherichia coli O157:H7 str. EDL933  Z0395  AAG54651.1  127 aa hypothetical protein 0.03 ●●○○○ -1.88 -1.88396621627105
Escherichia coli M12  CO715_08005  ATI05659.1  297 aa carbamate kinase 2.1e-27 ●●○○○ -1.88 -1.88335705939575
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3303  WP_001238434.1  E8XAK3  547 aa HAMP domain-containing protein 2.0e-13 ●●○○○ -1.88 -1.88263360123452
Serratia marcescens Strain UMH9  BVG96_13275  ASL98538.1  615 aa NADH-quinone oxidoreductase subunit L 0.036 ●●○○○ -1.88 -1.88172272509696
Escherichia coli M12  CO715_07615  ATI05595.1  45 aa stationary-phase-induced ribosome-associated protein 2.1e-8 ●●○○○ -1.88 -1.88106195323902
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3224  AIK81785.1  210 aa fabR transcriptional repressor FabR transcriptional dual regulator 4.2e-12 ●●○○○ -1.88 -1.88097545291029
Escherichia coli M12  CO715_15655  ATI07022.1  305 aa DNA-binding transcriptional regulator OxyR 5.1e-20 ●●○○○ -1.88 -1.88085330722477
Campylobacter jejuni subsp. jejuni 81-176  CJJ81176_1048  WP_002869124.1  A0A0H3P9C5  mapA  214 aa hypothetical protein 0.035 ●●○○○ -1.88 -1.88070609636
Escherichia coli M12  CO715_07400  ATI05555.1  684 aa DNA helicase IV 2.6e-10 ●●○○○ -1.88 -1.88064466121052
Acinetobacter baumannii ATCC 17978  A1S_2537  ABO12954.2  307 aa putative LysR-type transcriptional regulator 1.1e-15 ●●○○○ -1.88 -1.88048137506682
Campylobacter jejuni subsp. jejuni 81-176  CJJ81176_0077  WP_002799607.1  A0A0H3PGQ5  typA  602 aa translational GTPase TypA 0.035 ●●○○○ -1.88 -1.88033802805
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_1691  AIK80311.1  240 aa glnQ <1e-323 ●●○○○ -1.88 -1.87933681990934
Salmonella enterica Serovar Typhimurium ST4 74  STM474_1352  WP_000370992.1  E8XGF4  ydia  277 aa posphoenolpyruvate synthetase regulatory kinase/phosphorylase PpsR 0.0059 ●●○○○ -1.88 -1.87800108748937
Salmonella enterica Serovar Typhimurium ST4 74  STM474_1255  WP_000946082.1  E8XFI2  544 aa ABC transporter substrate-binding protein 0.00039 ●●○○○ -1.88 -1.87751726221577
Escherichia coli M12  CO715_01115  ATI04455.1  629 aa tRNA uridine(34) 5-carboxymethylaminomethyl synthesis enzyme MnmG 8.1e-5 ●●○○○ -1.88 -1.87730632498254
Campylobacter jejuni subsp. jejuni 81-176  CJJ81176_0186  WP_002857324.1  A0A0H3PF06  400 aa LL-diaminopimelate aminotransferase 0.036 ●●○○○ -1.88 -1.87721430253
Salmonella enterica Serovar Typhimurium ST4 74  STM474_0017  WP_001068132.1  E8XG37  177 aa hypothetical protein 8.9e-8 ●●○○○ -1.88 -1.87719354946081
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2735  AIK81325.1  331 aa hypothetical protein 3.0e-6 ●●○○○ -1.88 -1.87710829108431
Escherichia coli M12  CO715_10285  ATI06053.1  108 aa hypothetical protein 6.1e-24 ●●○○○ -1.88 -1.87668038693979
Campylobacter jejuni subsp. jejuni 81-176  CJJ81176_0978  WP_002853351.1  A1VZU6  purL  728 aa phosphoribosylformylglycinamidine synthase subunit PurL 0.036 ●●○○○ -1.88 -1.87568894234
Escherichia coli M12  CO715_05020  ATI05150.1  196 aa imidazole glycerol phosphate synthase subunit HisH 0.00035 ●●○○○ -1.88 -1.87521986484005
Escherichia coli M12  CO715_07755  ATI05615.1  173 aa RNA polymerase sigma factor FecI 5.7e-5 ●●○○○ -1.87 -1.8745939267973
Escherichia coli M12  CO715_04040  ATI04984.1  117 aa hypothetical protein 4.4e-13 ●●○○○ -1.87 -1.8741766347688
Escherichia coli M12  CO715_15980  ATI08833.1  255 aa tRNA glutamyl-Q(34) synthetase GluQRS 3.2e-13 ●●○○○ -1.87 -1.87375934274031
Acinetobacter baumannii ATCC 17978  A1S_2497  ABO12915.2  A3M7M1  proB  377 aa gamma-glutamyl kinase 2.4e-14 ●●○○○ -1.87 -1.87360499636898
Escherichia coli M12  CO715_04825  ATI05114.1  394 aa acetyl-CoA C-acetyltransferase 1.4e-5 ●●○○○ -1.87 -1.87355069672606
Mycobacterium avium subsp. paratuberculosis K10  MAP_3286  AAS05836.1  Q73UT0  IS1547  367 aa IS1547_2 0.023 ●●○○○ -1.87 -1.87313701464488
Salmonella enterica Serovar Typhimurium ST4 74  STM474_1547  WP_000924456.1  E8XIY3  247 aa Ni/Fe-hydrogenase, b-type cytochrome subunit 1.4e-11 ●●○○○ -1.87 -1.87232456212162
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3337  WP_000444735.1  E8XBB2  icc  275 aa 3',5'-cyclic-AMP phosphodiesterase 0.00021 ●●○○○ -1.87 -1.87174877815492
Escherichia coli M12  CO715_06210  ATI05348.1  267 aa 4-carboxymuconolactone decarboxylase 3.3e-15 ●●○○○ -1.87 -1.87125559056932
Escherichia coli CFT073  c1694  AAN80161.1  A0A0H2V6Z5  374 aa Hypothetical protein 0.037 ●●○○○ -1.87 -1.87079187279587
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3128  WP_000044409.1  E8X8R7  gcvA  305 aa transcriptional regulator GcvA 2.5e-10 ●●○○○ -1.87 -1.86996979442717
Acinetobacter baumannii ATCC 17978  A1S_2175  ABO12602.1  234 aa replicative DNA helicase;chromosome replication chain elongation 8.7e-7 ●●○○○ -1.87 -1.86954488460041
Escherichia coli M12  CO715_06055  ATI05319.1  291 aa LysR family transcriptional regulator 2.1e-38 ●●○○○ -1.87 -1.86896048441258
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2460  AIK81057.1  297 aa nicotinate-nucleotide diphosphorylase 8.6e-9 ●●○○○ -1.87 -1.8677525231417
Campylobacter jejuni subsp. jejuni 81-176  CJJ81176_1265  WP_002869078.1  A0A0H3PDT1  486 aa hypothetical protein 0.036 ●●○○○ -1.87 -1.86741108099
Escherichia coli O157:H7 str. EDL933  Z3620  AAG57483.1  470 aa hypothetical protein 0.031 ●●○○○ -1.87 -1.86731463241365
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_1665  AIK80285.1  619 aa nickel import ATP-binding protein NikE 0.039 ●●○○○ -1.87 -1.86650898366657
Escherichia coli M12  CO715_21005  ATI07988.1  477 aa PTS glucose EIICB component 9.6e-10 ●●○○○ -1.87 -1.8664567322416
Vibrio cholerae O1 biovar El Tor str. N16961  VC_1350  NP_230994.1  Q9KSA9  157 aa antioxidant 5.6e-9 ●●○○○ -1.87 -1.86546412741782
Salmonella enterica Serovar Typhimurium ST4 74  STM474_2452  WP_000754423.1  E8XF08  argT  260 aa lysine/arginine/ornithine ABC transporter substrate-binding protein ArgT 1.0e-13 ●●○○○ -1.87 -1.8654235663811
Escherichia coli M12  CO715_04060  ATI04988.1  457 aa siroheme synthase 8.5e-69 ●●○○○ -1.87 -1.86541350217035
Mycobacterium avium subsp. paratuberculosis K10  MAP_0816  AAS03133.1  Q742L9  310 aa hypothetical protein 0.023 ●●○○○ -1.86 -1.86489217244779
Salmonella enterica Serovar Typhimurium ST4 74  STM474_1319  WP_000459883.1  E8XGC1  celC  115 aa PTS N,N'-diacetylchitobiose transporter subunit IIA 0.0022 ●●○○○ -1.86 -1.86371810723175
Escherichia coli M12  CO715_03615  ATI04907.1  199 aa 5'-deoxynucleotidase 1.8e-6 ●●○○○ -1.86 -1.86249245797087
Salmonella enterica Serovar Typhimurium SL1344  SL1344_1338  CBW17434.1  A0A0H3NG92  sseF  260 aa Type III secretion system effector protein-regulates and maintains the SCV 6.6e-5 ●●○○○ -1.86 -1.86206909142459
Acinetobacter baumannii ATCC 17978  A1S_1055  ABO11487.2  1071 aa hypothetical protein 2.0e-27 ●●○○○ -1.86 -1.86202879206283
Mycobacterium avium subsp. paratuberculosis K10  MAP_0318  AAS02635.1  Q744M3  257 aa hypothetical protein 0.023 ●●○○○ -1.86 -1.86191521409392
Escherichia coli O157:H7 str. EDL933  Z3614  AAG57477.1  378 aa putative prophage DNA injection protein 0.032 ●●○○○ -1.86 -1.86168251207485
Escherichia coli M12  CO715_17200  ATI07300.1  570 aa assimilatory sulfite reductase (NADPH) hemoprotein subunit 0.0052 ●●○○○ -1.86 -1.86165787391387
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_1458  AIK80079.1  185 aa DNA-binding transcriptional repressor 0.021 ●●○○○ -1.86 -1.86107526504709
Salmonella enterica Serovar Typhimurium ST4 74  STM474_1579  WP_000450511.1  E8XJ14  sfcA  565 aa NAD-dependent malic enzyme 1.1e-13 ●●○○○ -1.86 -1.86032212909831
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A0885  NP_233271.1  Q9KL62  tdh  343 aa L-threonine 3-dehydrogenase 6.1e-9 ●●○○○ -1.86 -1.860255326829
Salmonella enterica Serovar Typhimurium SL1344  SL1344_3820  CBW19911.1  A0A0H3NHQ1  phoU  241 aa phosphate transport system regulatory protein 0.0007 ●●○○○ -1.86 -1.86018213523407
Escherichia coli M12  CO715_08190  ATI05694.1  362 aa 3-phosphoserine/phosphohydroxythreonine aminotransferase 3.9e-6 ●●○○○ -1.86 -1.85978005978563
Mycobacterium avium subsp. paratuberculosis K10  MAP_3849  AAS06399.1  Q73T70  1026 aa hypothetical protein 0.023 ●●○○○ -1.86 -1.85910435031147
Campylobacter jejuni subsp. jejuni 81-176  CJJ81176_0078  WP_002824650.1  A0A0H3P9K4  107 aa hypothetical protein 0.037 ●●○○○ -1.86 -1.85823117585
Escherichia coli M12  CO715_22895  ATI08322.1  318 aa GTPase 4.9e-23 ●●○○○ -1.86 -1.8574849536289
Salmonella enterica Serovar Typhimurium SL1344  SL1344_1774  CBW17868.1  A0A0H3NDR9  prc  682 aa tail-specific protease precursor 0.0013 ●●○○○ -1.86 -1.85603169341821
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4545  AIK83083.1  268 aa bacterial extracellular solute-binding, 3 familyprotein 1.6e-9 ●●○○○ -1.85 -1.85384928079492
Escherichia coli M12  CO715_20710  ATI07931.1  177 aa O-acetyl-ADP-ribose deacetylase 4.1e-6 ●●○○○ -1.85 -1.85310338732967
Escherichia coli O157:H7 str. EDL933  Z5109  AAG58822.1  406 aa escD 0.032 ●●○○○ -1.85 -1.85181484727563
Escherichia coli M12  CO715_02470  ATI04697.1  91 aa DNA-directed RNA polymerase subunit omega 4.3e-13 ●●○○○ -1.85 -1.85080828117293
Salmonella enterica Serovar Typhimurium ST4 74  STM474_2521  WP_000438890.1  E8XFM7  xapR  294 aa LysR family transcriptional regulator 3.4e-11 ●●○○○ -1.85 -1.85032831298329
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2559  AIK81156.1  377 aa chaperone protein DnaJ 3.2e-5 ●●○○○ -1.85 -1.84907791241932
Vibrio cholerae O1 biovar El Tor str. N16961  VC_2510  NP_232139.2  Q9KP66  pyrB  309 aa aspartate carbamoyltransferase 3.1e-7 ●●○○○ -1.85 -1.84889770428412
Escherichia coli O157:H7 str. EDL933  Z5122  AAG58835.1  99 aa sepZ 0.032 ●●○○○ -1.85 -1.84755443474116
Streptococcus pyogenes M1 5448  SP5448_09005  WP_002982262.1  255 aa 30S ribosomal protein S2 0.024 ●●○○○ -1.85 -1.84690397110151
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3203  WP_001192144.1  E8X9M7  visC  400 aa FAD-dependent 2-octaprenylphenol hydroxylase 8.6e-8 ●●○○○ -1.85 -1.84671200467326
Escherichia coli O157:H7 str. EDL933  Z1295  AAG55432.1  192 aa orf, hypothetical protein 0.033 ●●○○○ -1.85 -1.84592401393078
Salmonella enterica Serovar Typhimurium ST4 74  STM474_2793  WP_000503831.1  E8XIE8  909 aa replication protein 0.00039 ●●○○○ -1.85 -1.8454727442172
Escherichia coli M12  CO715_11625  ATI06296.1  263 aa DNA-binding transcriptional regulator KdgR 3.0e-14 ●●○○○ -1.84 -1.84434025473122
Escherichia coli M12  CO715_02430  ATI04690.1  213 aa orotate phosphoribosyltransferase 9.4e-7 ●●○○○ -1.84 -1.84434025473122
Vibrio cholerae O1 biovar El Tor str. N16961  VC_2730  NP_232357.1  P45773  epsG  146 aa general secretion pathway protein G 9.9e-7 ●●○○○ -1.84 -1.84374055000106
Escherichia coli M12  CO715_11755  ATI06320.1  493 aa outer membrane channel protein TolC 0.0001 ●●○○○ -1.84 -1.84329702465997
Mycobacterium avium subsp. paratuberculosis K10  MAP_3088c  AAS05636.1  Q73VC6  276 aa hypothetical protein 0.024 ●●○○○ -1.84 -1.84287116565069
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3626  AIK82181.1  300 aa putative 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD <1e-323 ●●○○○ -1.84 -1.84222548309787
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3630  AIK82184.1  126 aa arnF <1e-323 ●●○○○ -1.84 -1.84214130641482
Escherichia coli M12  CO715_17125  ATI07287.1  201 aa adenylyl-sulfate kinase 0.00094 ●●○○○ -1.84 -1.84141921053173
Acinetobacter baumannii ATCC 17978  A1S_0763  ABO11203.2  532 aa NADH dehydrogenase I chain M membrane subunit 2.9e-6 ●●○○○ -1.84 -1.8405835892099
Escherichia coli O157:H7 str. EDL933  Z4071  AAG57869.1  50 aa hypothetical protein 0.033 ●●○○○ -1.84 -1.8404223120214
Escherichia coli M12  CO715_12775  ATI06504.1  147 aa hypothetical protein 3.9e-15 ●●○○○ -1.84 -1.84037598046049
Escherichia coli CFT073  c2568  AAN81023.1  A0A0H2V8L7  wcaM  464 aa Colanic acid biosynthesis protein wcaM 0.03 ●●○○○ -1.84 -1.83999621444471
Mycobacterium avium subsp. paratuberculosis K10  MAP_3530  AAS06080.1  Q73U38  228 aa hypothetical protein 0.024 ●●○○○ -1.84 -1.83994863570172
Escherichia coli M12  CO715_10495  ATI06089.1  342 aa Mal regulon transcriptional regulator MalI 4.6e-16 ●●○○○ -1.84 -1.8387068123465
Salmonella enterica Serovar Typhimurium ST4 74  STM474_0871  WP_014343820.1  E8XBV8  moeA  413 aa molybdopterin molybdotransferase MoeA 0.00032 ●●○○○ -1.84 -1.83820665308944
Mycobacterium avium subsp. paratuberculosis K10  MAP_3760c  AAS06310.1  Q73TF8  128 aa hypothetical protein 0.024 ●●○○○ -1.84 -1.83808326335519
Salmonella enterica Serovar Typhimurium ST4 74  STM474_0445  WP_000668709.1  E8XKL2  thiI  482 aa tRNA 4-thiouridine(8) synthase ThiI 1.2e-12 ●●○○○ -1.84 -1.83773281423796
Salmonella enterica Serovar Typhimurium SL1344  SL1344_0720  CBW16818.1  A0A0H3N950  sucC  388 aa succinyl-CoA synthetase beta chain 0.00082 ●●○○○ -1.84 -1.83736259784799
Escherichia coli M12  CO715_02660  ATI04733.1  353 aa AI-2E family transporter 7.2e-5 ●●○○○ -1.84 -1.83599441416126
Mycobacterium avium subsp. paratuberculosis K10  MAP_2887c  AAS05204.1  Q73VX4  153 aa hypothetical protein 0.024 ●●○○○ -1.83 -1.83444384495322
Escherichia coli O157:H7 str. EDL933  Z5718  AAG59315.1  253 aa putative ARAC-type regulatory protein 0.033 ●●○○○ -1.83 -1.83443619326609
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3517  WP_001171579.1  E8XD60  221 aa GntR family transcriptional regulator 0.00052 ●●○○○ -1.83 -1.83367877035525
Salmonella enterica Serovar Typhimurium ST4 74  STM474_0030  WP_000839833.1  E8XG50  95 aa hypothetical protein 8.8e-8 ●●○○○ -1.83 -1.83362321666282
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3731  WP_000822973.1  E8XF76  livK  369 aa high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK 0.0003 ●●○○○ -1.83 -1.83304154210923
Mycobacterium avium subsp. paratuberculosis K10  MAP_2171c  AAS04488.1  Q73XY7  mbtF  1412 aa MbtF 0.024 ●●○○○ -1.83 -1.83293725178277
Escherichia coli M12  CO715_12780  ATI06505.1  100 aa hypothetical protein 1.4e-7 ●●○○○ -1.83 -1.83244743191903
Retrieved entries 2,001–2,100 out of 36,363 total in 631.7 ms (Link to these results)