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Pathogen
Any pathogen
Acinetobacter baumannii ATCC 17978
Campylobacter jejuni subsp. jejuni 81-176
Escherichia coli CFT073
Escherichia coli M12
Escherichia coli O157:H7 str. EDL933
Haemophilus influenzae Rd KW20
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1
Mycobacterium avium subsp. paratuberculosis K10
Porphyromonas gingivalis ATCC 33277
Salmonella enterica Serovar Typhimurium SL1344
Salmonella enterica Serovar Typhimurium ST4 74
Serratia marcescens Strain UMH9
Streptococcus pyogenes M1 5448
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio parahaemolyticus RIMD 2210633
Sorted by significance (p<0.05) and Fitness z-Scores (highest impact first):
Download Table
Pathogen
Locus
Protein
UniProt
Gene
Length
Product
p-Value
Fitness z-Score
Precise fitness z-Score
Escherichia coli M12
CO715_15920
ATI07066.1
171 aa
twin-arginine translocase subunit TatB
1.4e-5
●●○○○ -1.37
-1.37342620057154
Escherichia coli M12
CO715_04645
ATI05087.1
305 aa
hypothetical protein
3.6e-21
●●○○○ -1.37
-1.37175703245755
Escherichia coli M12
CO715_05115
ATI05164.1
124 aa
toxin CbtA
3.6e-13
●●○○○ -1.37
-1.3715483864433
Escherichia coli M12
CO715_06625
ATI05417.1
326 aa
iron ABC transporter permease
6.4e-8
●●○○○ -1.37
-1.37133974042905
Escherichia coli M12
CO715_16195
ATI07116.1
400 aa
type IV pilin biogenesis protein
1.1e-14
●●○○○ -1.37
-1.37092244840055
Escherichia coli M12
CO715_09710
ATI05959.1
362 aa
endolytic peptidoglycan transglycosylase RlpA
1.5e-14
●●○○○ -1.37
-1.37092244840055
Escherichia coli M12
CO715_06350
ATI08747.1
543 aa
oligopeptide ABC transporter substrate-binding protein OppA
4.9e-30
●●○○○ -1.37
-1.37050515637205
Escherichia coli M12
CO715_02985
ATI04793.1
365 aa
sulfate/thiosulfate import ATP-binding protein CysA
0.00045
●●○○○ -1.37
-1.37050515637205
Escherichia coli M12
CO715_06365
ATI05375.1
891 aa
bifunctional acetaldehyde-CoA/alcohol dehydrogenase
4.9e-54
●●○○○ -1.37
-1.36967057231506
Escherichia coli M12
CO715_15295
ATI06958.1
309 aa
formate dehydrogenase accessory protein FdhE
0.00014
●●○○○ -1.37
-1.36967057231506
Escherichia coli M12
CO715_17420
ATI07342.1
131 aa
hypothetical protein
2.6e-10
●●○○○ -1.37
-1.36862734224381
Escherichia coli M12
CO715_00035
ATI04262.1
246 aa
tRNA (cytosine(32)/uridine(32)-2'-O)-methyltransferase TrmJ
0.0052
●●○○○ -1.37
-1.36800140420107
Escherichia coli M12
CO715_11230
ATI06224.1
216 aa
sulfate ABC transporter ATP-binding protein
0.00032
●●○○○ -1.37
-1.36779275818682
Escherichia coli M12
CO715_19080
ATI07633.1
307 aa
LysR family transcriptional regulator
1.8e-28
●●○○○ -1.37
-1.36695817412982
Escherichia coli M12
CO715_19945
ATI07790.1
623 aa
peptidyl-prolyl cis-trans isomerase
2.2e-24
●●○○○ -1.37
-1.36633223608708
Escherichia coli M12
CO715_02815
ATI04763.1
316 aa
transaldolase
4.2e-44
●●○○○ -1.37
-1.36612359007283
Escherichia coli M12
CO715_06945
ATI05473.1
181 aa
terminase small subunit
1.0e-12
●●○○○ -1.37
-1.36549765203008
Escherichia coli M12
CO715_14620
ATI06836.1
193 aa
DNA gyrase subunit B
3.6e-22
●●○○○ -1.36
-1.36487171398733
Escherichia coli M12
CO715_06590
ATI05411.1
356 aa
dihydroxyacetone kinase subunit DhaK
4.4e-10
●●○○○ -1.36
-1.36403712993034
Escherichia coli M12
CO715_23115
ATI08362.1
328 aa
hypothetical protein
1.1e-8
●●○○○ -1.36
-1.36361983790184
Escherichia coli M12
CO715_04725
ATI05101.1
375 aa
flagellar hook-length control protein FliK
3.3e-5
●●○○○ -1.36
-1.36111608573085
Escherichia coli M12
CO715_18110
ATI07462.1
492 aa
acetyl-CoA hydrolase
3.4e-22
●●○○○ -1.36
-1.36007285565961
Escherichia coli M12
CO715_00200
ATI04293.1
216 aa
anti-sigma-E factor RseA
0.00011
●●○○○ -1.36
-1.35965556363111
Escherichia coli M12
CO715_08535
ATI05756.1
125 aa
hypothetical protein
2.0e-10
●●○○○ -1.36
-1.35944691761686
Escherichia coli M12
CO715_02970
ATI04790.1
338 aa
sulfate ABC transporter substrate-binding protein
0.037
●●○○○ -1.36
-1.35861233355987
Escherichia coli M12
CO715_17095
ATI07281.1
253 aa
5'/3'-nucleotidase SurE
0.012
●●○○○ -1.36
-1.35756910348862
Escherichia coli M12
CO715_04840
ATI05117.1
220 aa
acetate CoA-transferase subunit alpha
1.7e-8
●●○○○ -1.36
-1.35736045747437
Escherichia coli M12
CO715_04410
ATI05049.1
181 aa
bifunctional adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase
2.4e-5
●●○○○ -1.36
-1.35736045747437
Escherichia coli M12
CO715_00900
ATI04416.1
467 aa
chromosomal replication initiator protein DnaA
4.2e-11
●●○○○ -1.36
-1.35589993537463
Escherichia coli M12
CO715_11355
ATI06248.1
294 aa
D-hexose-6-phosphate mutarotase
1.7e-6
●●○○○ -1.36
-1.35548264334614
Escherichia coli M12
CO715_14340
ATI06781.1
176 aa
helix-turn-helix transcriptional regulator
4.8e-24
●●○○○ -1.35
-1.35443941327489
Escherichia coli M12
CO715_09690
ATI05955.1
105 aa
ribosome silencing factor RsfS
5.1e-7
●●○○○ -1.35
-1.35381347523214
Escherichia coli M12
CO715_19040
ATI07626.1
330 aa
TDT family transporter
0.003
●●○○○ -1.35
-1.3527702451609
Escherichia coli M12
CO715_21665
ATI08105.1
156 aa
DUF1456 domain-containing protein
2.3e-9
●●○○○ -1.35
-1.35256159914665
Escherichia coli M12
CO715_06905
ATI05467.1
275 aa
manganese/iron transporter ATP-binding protein
1.3e-5
●●○○○ -1.35
-1.35130972306116
Escherichia coli M12
CO715_02365
ATI04678.1
335 aa
lipopolysaccharide 3-alpha-galactosyltransferase
0.019
●●○○○ -1.35
-1.35130972306116
Escherichia coli M12
CO715_19705
ATI07745.1
310 aa
glutaminase
7.8e-7
●●○○○ -1.35
-1.35005784697566
Escherichia coli M12
CO715_21325
ATI08042.1
231 aa
16S rRNA pseudouridine(516) synthase
1.8e-9
●●○○○ -1.35
-1.34984920096142
Escherichia coli M12
CO715_14480
ATI06809.1
355 aa
hypothetical protein
0.00046
●●○○○ -1.35
-1.34964055494717
Escherichia coli M12
CO715_11970
ATI06361.1
162 aa
hydrogenase-2 operon protein HybE
3.5e-8
●●○○○ -1.35
-1.34734544879043
Escherichia coli M12
CO715_06775
ATI05445.1
270 aa
septum site-determining protein MinD
6.5e-21
●●○○○ -1.35
-1.34713680277618
Escherichia coli M12
CO715_09945
ATI06003.1
271 aa
ferric enterobactin transport ATP-binding protein FepC
1.3e-8
●●○○○ -1.35
-1.34671951074768
Escherichia coli M12
CO715_05485
ATI05228.1
440 aa
murein DD-endopeptidase MepM
2.9e-15
●●○○○ -1.35
-1.34651086473343
Escherichia coli M12
CO715_21915
ATI08152.1
153 aa
hypothetical protein
5.8e-21
●●○○○ -1.35
-1.34588492669069
Escherichia coli M12
CO715_22140
ATI08192.1
491 aa
ketol-acid reductoisomerase
3.6e-33
●●○○○ -1.35
-1.34525898864794
Escherichia coli M12
CO715_11965
ATI06360.1
164 aa
hydrogenase 2 maturation protease
5.9e-5
●●○○○ -1.35
-1.34525898864794
Escherichia coli M12
CO715_11650
ATI06301.1
273 aa
undecaprenyl-diphosphatase
0.00078
●●○○○ -1.35
-1.34525898864794
Escherichia coli M12
CO715_00405
ATI04328.1
61 aa
addiction module toxin, HicA family
1.8e-10
●●○○○ -1.34
-1.34463305060519
Escherichia coli M12
CO715_06700
ATI05431.1
510 aa
SpoVR family protein
4.8e-8
●●○○○ -1.34
-1.3442157585767
Escherichia coli M12
CO715_00820
ATI04404.1
137 aa
heat-shock protein IbpA
8.6e-6
●●○○○ -1.34
-1.3442157585767
Escherichia coli M12
CO715_11870
ATI06342.1
275 aa
2,5-diketo-D-gluconic acid reductase A
2.5e-7
●●○○○ -1.34
-1.34254659046271
Escherichia coli M12
CO715_19280
ATI07669.1
171 aa
methylated-DNA--[protein]-cysteine S-methyltransferase
0.0024
●●○○○ -1.34
-1.34212929843421
Escherichia coli M12
CO715_19020
ATI07622.1
178 aa
XRE family transcriptional regulator
2.0e-6
●●○○○ -1.34
-1.34171200640571
Escherichia coli M12
CO715_14785
ATI06868.1
281 aa
sn-glycerol 3-phosphate ABC transporter permease
1.9e-57
●●○○○ -1.34
-1.34004283829172
Escherichia coli M12
CO715_13530
ATI06637.1
79 aa
hypothetical protein
5.4e-5
●●○○○ -1.34
-1.33941690024897
Escherichia coli M12
CO715_10690
ATI06123.1
193 aa
superoxide dismutase [Fe]
0.00015
●●○○○ -1.34
-1.33941690024897
Escherichia coli M12
CO715_02695
ATI04740.1
526 aa
hydrogenase
1.8e-39
●●○○○ -1.34
-1.33858231619198
Escherichia coli M12
CO715_10990
ATI06178.1
183 aa
glutathione peroxidase
7.7e-22
●●○○○ -1.34
-1.33858231619198
Escherichia coli M12
CO715_10810
ATI06144.1
334 aa
murein L,D-transpeptidase
2.5e-22
●●○○○ -1.34
-1.33816502416348
Escherichia coli M12
CO715_03135
ATI04817.1
108 aa
fructose-like phosphotransferase enzyme IIB component 1
3.9e-5
●●○○○ -1.34
-1.33774773213498
Escherichia coli M12
CO715_19255
ATI07665.1
302 aa
LysR family transcriptional regulator
3.8e-16
●●○○○ -1.34
-1.33753908612073
Escherichia coli M12
CO715_01330
ATI04493.1
141 aa
transcriptional regulator
0.0016
●●○○○ -1.34
-1.33691314807799
Escherichia coli M12
CO715_20905
ATI07968.1
317 aa
flagellar hook-filament junction protein FlgL
5.0e-27
●●○○○ -1.34
-1.335243979964
Escherichia coli M12
CO715_06175
ATI05341.1
229 aa
type 1 glutamine amidotransferase domain-containing protein
0.0039
●●○○○ -1.33
-1.33294887380726
Escherichia coli M12
CO715_21150
ATI08014.1
216 aa
hypothetical protein
8.7e-11
●●○○○ -1.33
-1.33274022779301
Escherichia coli M12
CO715_23850
ATI08475.1
197 aa
antibiotic transporter
4.2e-6
●●○○○ -1.33
-1.33232293576451
Escherichia coli M12
CO715_06400
ATI05382.1
280 aa
formyltetrahydrofolate deformylase
2.9e-171
●●○○○ -1.33
-1.33190564373601
Escherichia coli M12
CO715_11615
ATI06295.1
47 aa
PhoP regulon feedback inhibition membrane protein MgrB
0.04
●●○○○ -1.33
-1.33169699772176
Escherichia coli M12
CO715_17240
ATI07308.1
445 aa
MFS transporter
6.6e-49
●●○○○ -1.33
-1.33148835170752
Escherichia coli M12
CO715_05175
ATI05175.1
250 aa
L-cystine ABC transporter ATP-binding protein YecC
3.9e-13
●●○○○ -1.33
-1.33148835170752
Escherichia coli M12
CO715_22975
ATI08336.1
227 aa
hypothetical protein
3.2e-7
●●○○○ -1.33
-1.33148835170752
Escherichia coli M12
CO715_00585
ATI04363.1
324 aa
bifunctional glyoxylate/hydroxypyruvate reductase B
1.4e-44
●●○○○ -1.33
-1.33086241366477
Escherichia coli M12
CO715_20335
ATI07865.1
275 aa
taurine transporter subunit
1.8e-11
●●○○○ -1.33
-1.33065376765052
Escherichia coli M12
CO715_06630
ATI05418.1
252 aa
ABC transporter ATP-binding protein
9.2e-31
●●○○○ -1.33
-1.33044512163627
Escherichia coli M12
CO715_10410
ATI06073.1
314 aa
DUF1471 domain-containing protein
2.6e-32
●●○○○ -1.33
-1.32981918359353
Escherichia coli M12
CO715_15770
ATI07038.1
67 aa
hypothetical protein
0.004
●●○○○ -1.33
-1.32940189156503
Escherichia coli M12
CO715_16715
ATI07214.1
109 aa
hypothetical protein
0.0001
●●○○○ -1.33
-1.32898459953653
Escherichia coli M12
CO715_02450
ATI04694.1
274 aa
DNA damage-inducible protein D
2.9e-69
●●○○○ -1.33
-1.32877595352228
Escherichia coli M12
CO715_15080
ATI06921.1
329 aa
aldo/keto reductase
2.3e-44
●●○○○ -1.33
-1.32877595352228
Escherichia coli M12
CO715_10090
ATI06025.1
57 aa
protein GnsB
1.4e-7
●●○○○ -1.33
-1.32815001547953
Escherichia coli M12
CO715_04625
ATI05083.1
231 aa
phosphohydrolase
1.1e-13
●●○○○ -1.33
-1.32794136946529
Escherichia coli M12
CO715_20035
ATI07808.1
303 aa
2-dehydropantoate 2-reductase
1.5e-6
●●○○○ -1.33
-1.32752407743679
Escherichia coli M12
CO715_07830
ATI05628.1
129 aa
RusA family crossover junction endodeoxyribonuclease
1.5e-7
●●○○○ -1.33
-1.3258549093228
Escherichia coli M12
CO715_10485
ATI06087.1
196 aa
TetR family transcriptional regulator
1.5e-18
●●○○○ -1.33
-1.32522897128005
Escherichia coli M12
CO715_10205
ATI06039.1
356 aa
phage replisome organizer
4.4e-94
●●○○○ -1.32
-1.32481167925155
Escherichia coli M12
CO715_00210
ATI04295.1
159 aa
SoxR reducing system protein RseC
3.7e-12
●●○○○ -1.32
-1.32105605099507
Escherichia coli M12
CO715_03530
ATI04890.1
228 aa
histidine ABC transporter permease
7.6e-7
●●○○○ -1.32
-1.32043011295233
Escherichia coli M12
CO715_00135
ATI04282.1
392 aa
outer membrane protein assembly factor BamB
1.3e-6
●●○○○ -1.32
-1.32043011295233
Escherichia coli M12
CO715_03020
ATI04800.1
323 aa
cysteine synthase A
0.00048
●●○○○ -1.32
-1.32043011295233
Escherichia coli M12
CO715_10120
ATI06029.1
103 aa
hypothetical protein
9.7e-6
●●○○○ -1.32
-1.32022146693808
Escherichia coli M12
CO715_08145
ATI05685.1
410 aa
winged helix-turn-helix domain-containing protein
3.9e-5
●●○○○ -1.32
-1.32022146693808
Escherichia coli M12
CO715_24380
ATI08572.1
176 aa
hypothetical protein
1.7e-11
●●○○○ -1.32
-1.31959552889533
Escherichia coli M12
CO715_11135
ATI06206.1
112 aa
osmotically-inducible lipoprotein E
7.9e-13
●●○○○ -1.32
-1.31876094483834
Escherichia coli M12
CO715_22170
ATI08198.1
109 aa
thiol reductase thioredoxin
2.4e-7
●●○○○ -1.32
-1.31813500679559
Escherichia coli M12
CO715_12155
ATI06395.1
123 aa
type II secretion system protein GspI
3.5e-28
●●○○○ -1.32
-1.31792636078134
Escherichia coli M12
CO715_14135
ATI06745.1
385 aa
carbohydrate diacid regulon transcriptional regulator CdaR
0.00018
●●○○○ -1.32
-1.31792636078134
Escherichia coli M12
CO715_09850
ATI05984.1
521 aa
alkyl hydroperoxide reductase subunit F
7.7e-43
●●○○○ -1.32
-1.31771771476709
Escherichia coli M12
CO715_08505
ATI05750.1
53 aa
putrescine/spermidine ABC transporter substrate-binding protein
2.1e-7
●●○○○ -1.32
-1.31709177672434
Escherichia coli M12
CO715_02950
ATI04786.1
474 aa
PTS N-acetylmuramic acid transporter subunits IIBC
1.4e-7
●●○○○ -1.32
-1.3168831307101
Escherichia coli M12
CO715_00185
ATI04290.1
245 aa
tRNA (adenosine(37)-N6)-methyltransferase TrmM
2.3e-6
●●○○○ -1.32
-1.31625719266735
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