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Sorted by significance (p<0.05) and Fitness z-Scores (highest impact first):

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Pathogen Locus Protein UniProt Gene Length Product p-Value Fitness z-Score  Precise fitness z-Score
Escherichia coli M12  CO715_01445  ATI04511.1  602 aa fumarate reductase (quinol) flavoprotein subunit 1.1e-12 ●●●○○ -2.2 -2.19903847895428
Haemophilus influenzae Rd KW20  HI_1397  NP_439550.1  P43749  holC  144 aa DNA polymerase III subunit chi 0.03 ●●●○○ -2.2 -2.1983326443107
Haemophilus influenzae Rd KW20  HI_0328  NP_438492.3  P43771  efp  188 aa elongation factor P 0.03 ●●●○○ -2.2 -2.1983326443107
Haemophilus influenzae Rd KW20  HI_0883  NP_439044.1  P44917  456 aa Na+/alanine symporter 0.03 ●●●○○ -2.2 -2.1983326443107
Salmonella enterica Serovar Typhimurium SL1344  SL1344_4050  CBW20139.1  A0A0H3NI94  metL  810 aa bifunctional aspartokinase II/homoserine dehydrogenase IIcan I write 8.5e-7 ●●●○○ -2.2 -2.19779589773921
Mycobacterium avium subsp. paratuberculosis K10  MAP_0128c  AAS02445.1  Q745C7  285 aa hypothetical protein 0.012 ●●●○○ -2.2 -2.19599795044318
Salmonella enterica Serovar Typhimurium ST4 74  STM474_0589  WP_001156978.1  E8X940  ybdg  415 aa mechanosensitive ion channel family protein 1.7e-6 ●●●○○ -2.2 -2.19519254158835
Salmonella enterica Serovar Typhimurium ST4 74  STM474_2848  WP_014344393.1  E8XJ74  160 aa hypothetical protein 2.0e-6 ●●●○○ -2.2 -2.19519254158835
Mycobacterium avium subsp. paratuberculosis K10  MAP_0739  AAS03056.1  Q742U6  157 aa hypothetical protein 0.012 ●●●○○ -2.19 -2.19482191535577
Salmonella enterica Serovar Typhimurium SL1344  SL1344_3467  CBW19562.1  A0A0H3NT12  pckA  539 aa phosphoenolpyruvate carboxykinase 0.00011 ●●●○○ -2.19 -2.19420298759923
Escherichia coli M12  CO715_05780  ATI05277.1  110 aa head decoration protein 5.7e-14 ●●●○○ -2.19 -2.19382232859806
Escherichia coli O157:H7 str. EDL933  Z0090  AAG54384.1  334 aa transcriptional repressor of fru operon and others 0.016 ●●●○○ -2.19 -2.19351609325981
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0297  NP_229952.1  Q9KV60  aroQ  150 aa 3-dehydroquinate dehydratase 1.5e-8 ●●●○○ -2.19 -2.19251756038549
Escherichia coli O157:H7 str. EDL933  Z0042  AAG54339.1  297 aa carnitine racemase 0.016 ●●●○○ -2.19 -2.19212231155927
Salmonella enterica Serovar Typhimurium ST4 74  STM474_2153  WP_000178807.1  E8XC22  yeeF  454 aa putrescine/proton symporter PlaP 3.6e-16 ●●●○○ -2.19 -2.19017178919536
Streptococcus pyogenes M1 5448  SP5448_09050  WP_002982219.1  204 aa anaerobic ribonucleoside-triphosphate reductase activating protein 0.017 ●●●○○ -2.19 -2.18913976441258
Vibrio cholerae O1 biovar El Tor str. N16961  VC_2320  NP_231951.1  Q9KPP6  recB  1208 aa exodeoxyribonuclease V 2.6e-8 ●●●○○ -2.19 -2.18841480273155
Streptococcus pyogenes M1 5448  SP5448_05090  WP_002991766.1  373 aa sodium ion-translocating decarboxylase subunit beta 0.029 ●●●○○ -2.19 -2.18817842791451
Escherichia coli CFT073  c1923  AAN80381.1  A0A0H2V7F0  pqqL  931 aa Probable zinc protease pqqL 0.05 ●●●○○ -2.19 -2.18810903513216
Acinetobacter baumannii ATCC 17978  A1S_1703  ABO12130.1  54 aa dihydrolipoamide dehydrogenase 6.7e-23 ●●●○○ -2.19 -2.1880825962933
Escherichia coli M12  CO715_07845  ATI05631.1  313 aa helix-turn-helix domain-containing protein 3.7e-8 ●●●○○ -2.19 -2.18756294817059
Escherichia coli M12  CO715_03850  ATI04950.1  256 aa pimeloyl-[acyl-carrier protein] methyl ester esterase 2.5e-13 ●●●○○ -2.19 -2.1867283641136
Mycobacterium avium subsp. paratuberculosis K10  MAP_1066  AAS03383.1  Q741M4  352 aa hypothetical protein 0.012 ●●●○○ -2.19 -2.18511428125618
Vibrio cholerae O1 biovar El Tor str. N16961  VC_2732  NP_232359.1  P37093  epsE  503 aa general secretion pathway protein E 1.7e-8 ●●●○○ -2.18 -2.18418590363754
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3728  AIK82283.1  187 aa glutamine amidotransferase of anthranilate synthase/aminodeoxychorismate synthase family protein <1e-323 ●●●○○ -2.18 -2.18388832239607
Acinetobacter baumannii ATCC 17978  A1S_0544  ABO10997.2  163 aa acetolactate synthase isozyme III small subunit 7.6e-29 ●●●○○ -2.18 -2.18223862995786
Escherichia coli O157:H7 str. EDL933  Z1955  AAG56043.1  304 aa orf, hypothetical protein 0.017 ●●●○○ -2.18 -2.18128919014696
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3841  WP_000576056.1  E8XFY3  yiaL  154 aa YhcH/YjgK/YiaL family protein 3.9e-5 ●●●○○ -2.18 -2.17965275686541
Escherichia coli O157:H7 str. EDL933  Z5051  AAG58771.1  337 aa putative LPS biosynthesis enzyme 0.017 ●●●○○ -2.18 -2.1768421391839
Streptococcus pyogenes M1 5448  SP5448_03935  WP_002984003.1  351 aa peptidylprolyl isomerase PrsA 0.031 ●●●○○ -2.18 -2.17664238993773
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3970  AIK82518.1  549 aa dihydroxyacetone kinase 0.00061 ●●●○○ -2.18 -2.17617761438516
Salmonella enterica Serovar Typhimurium SL1344  SL1344_4075  CBW20163.1  A0A0H3NK71  udhA  466 aa possible pyridine nucleotide-disulphide oxidoreductase 8.6e-7 ●●●○○ -2.18 -2.17603611863431
Vibrio cholerae O1 biovar El Tor str. N16961  VC_2655  NP_232283.2  Q9KNS6  epmA  324 aa lysyl-tRNA synthetase 1.9e-14 ●●●○○ -2.17 -2.1722675191039
Salmonella enterica Serovar Typhimurium ST4 74  STM474_0297  WP_001168956.1  E8XIV0  sciS  1289 aa type VI secretion system membrane subunit TssM 2.7e-16 ●●●○○ -2.17 -2.17153203780801
Streptococcus pyogenes M1 5448  SP5448_04480  WP_011018133.1  210 aa SAM-dependent DNA methyltransferase 0.013 ●●●○○ -2.17 -2.17087437094934
Escherichia coli O157:H7 str. EDL933  Z4929  AAG58657.1  274 aa putative ARAC-type regulatory protein 0.017 ●●●○○ -2.17 -2.17068598545729
Vibrio cholerae O1 biovar El Tor str. N16961  VC_1064  NP_230709.1  Q9KT41  143 aa lipoprotein-like protein 3.4e-11 ●●●○○ -2.17 -2.17051640315865
Mycobacterium avium subsp. paratuberculosis K10  MAP_0951  AAS03268.1  Q741Y6  541 aa hypothetical protein 0.012 ●●●○○ -2.17 -2.17030281775118
Salmonella enterica Serovar Typhimurium SL1344  SL1344_3821  CBW19912.1  A0A0H3NU57  pstB  257 aa phosphate transport ATP-binding protein 1.9e-7 ●●●○○ -2.17 -2.16991023312452
Acinetobacter baumannii ATCC 17978  A1S_2904  ABO13310.2  308 aa branched-chain amino acid transferase 2.9e-31 ●●●○○ -2.17 -2.16836906572855
Mycobacterium avium subsp. paratuberculosis K10  MAP_3750  AAS06300.1  Q73TG8  mmpS1  154 aa MmpS1 0.013 ●●●○○ -2.17 -2.16569559657789
Salmonella enterica Serovar Typhimurium ST4 74  STM474_1950  WP_000036392.1  E8XA65  cheB  349 aa chemotaxis response regulator protein-glutamate methylesterase 8.3e-18 ●●●○○ -2.17 -2.16548700619392
Vibrio cholerae O1 biovar El Tor str. N16961  VC_1706  NP_231342.1  Q9KRD6  305 aa transcriptional activator MetR 2.2e-9 ●●●○○ -2.16 -2.16424906257656
Streptococcus pyogenes M1 5448  SP5448_07850  WP_010921931.1  291 aa DNA polymerase III subunit delta' 0.013 ●●●○○ -2.16 -2.16318367896483
Escherichia coli O157:H7 str. EDL933  Z1543  AAG55658.1  539 aa putative outer membrane transporter of ShlA/HecA/FhaA exoprotein family 0.017 ●●●○○ -2.16 -2.16317924577811
Salmonella enterica Serovar Typhimurium ST4 74  STM474_1240  WP_001520581.1  E8XFH0  envE  173 aa lipoprotein 0.00012 ●●●○○ -2.16 -2.16309614768421
Acinetobacter baumannii ATCC 17978  A1S_1031  ABO11463.1  218 aa DNA-binding ATP-dependent protease La 1.3e-14 ●●●○○ -2.16 -2.16298875355521
Mycobacterium avium subsp. paratuberculosis K10  MAP_2230c  AAS04547.1  Q73XS9  3679 aa hypothetical protein 0.013 ●●●○○ -2.16 -2.16235663007334
Vibrio parahaemolyticus RIMD 2210633  VP_0738  BAC59001.1  Q87RN9  pth  196 aa peptidyl-tRNA hydrolase 0.034 ●●●○○ -2.16 -2.16091166353029
Salmonella enterica Serovar Typhimurium ST4 74  STM474_2553  WP_000102881.1  E8XFQ9  amiA  289 aa N-acetylmuramoyl-L-alanine amidase AmiA 1.5e-13 ●●●○○ -2.16 -2.15943376005955
Salmonella enterica Serovar Typhimurium SL1344  SL1344_1161  CBW17257.1  A0A0H3NFP4  sifA  336 aa Type III secretion system effector protein-necessary for Sif formation and maintaining the SCV. Has GAP activity 0.00016 ●●●○○ -2.16 -2.15581934945813
Vibrio parahaemolyticus RIMD 2210633  VP_3037  BAC61300.1  Q87KE0  purK  377 aa phosphoribosylaminoimidazole carboxylase, ATPase subunit 0.034 ●●●○○ -2.16 -2.1550350582189
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A0387  NP_232781.1  Q9KMG9  169 aa toxin resistance protein 1.7e-5 ●●●○○ -2.15 -2.15444992417574
Vibrio parahaemolyticus RIMD 2210633  VP_0577  BAC58840.1  Q87S47  232 aa phosphate transport system regulatory protein PhoU 0.034 ●●●○○ -2.15 -2.15444787689464
Salmonella enterica Serovar Typhimurium ST4 74  STM474_0920  WP_000069000.1  E8XCP1  ybjT  477 aa SDR family oxidoreductase 8.8e-5 ●●●○○ -2.15 -2.15420855294102
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3233  WP_000032793.1  E8XAD5  243 aa hypothetical protein 4.6e-32 ●●●○○ -2.15 -2.15416802042694
Porphyromonas gingivalis ATCC 33277  PGN_0580  WP_012457616.1  B2RIA4  1870 aa ATP-binding protein 0.033 ●●●○○ -2.15 -2.15408847786394
Escherichia coli O157:H7 str. EDL933  Z5175  AAG58883.1  307 aa putative ARAC-type regulatory protein 0.018 ●●●○○ -2.15 -2.15337406109916
Escherichia coli O157:H7 str. EDL933  Z1019  AAG55170.1  670 aa hypothetical protein 0.018 ●●●○○ -2.15 -2.15271251069414
Salmonella enterica Serovar Typhimurium ST4 74  STM474_4450  WP_014344259.1  E8X9Q5  ssb  63 aa hypothetical protein 3.8e-11 ●●●○○ -2.15 -2.15192992613255
Mycobacterium avium subsp. paratuberculosis K10  MAP_3607  AAS06157.1  Q73TW1  537 aa hypothetical protein 0.013 ●●●○○ -2.15 -2.1504842012752
Salmonella enterica Serovar Typhimurium ST4 74  STM474_4309  WP_001120789.1  E8XL81  sthA  466 aa Si-specific NAD(P)(+) transhydrogenase 1.9e-13 ●●●○○ -2.15 -2.15035228228063
Escherichia coli O157:H7 str. EDL933  Z2960  AAG56894.1  165 aa cytoplasmic ferritin (an iron storage protein) 0.018 ●●●○○ -2.15 -2.15031515122468
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_1161  AIK79784.1  269 aa sapF 4.0e-5 ●●●○○ -2.15 -2.1500811927699
Salmonella enterica Serovar Typhimurium ST4 74  STM474_4398  WP_000593182.1  E8X8W6  gtrA  120 aa GtrA family protein 4.0e-10 ●●●○○ -2.15 -2.14980273772891
Acinetobacter baumannii ATCC 17978  A1S_2920  ABO13325.2  283 aa putative phosphoesterase (PHP family) 7.8e-24 ●●●○○ -2.15 -2.14914590863428
Salmonella enterica Serovar Typhimurium ST4 74  STM474_1665  WP_000089153.1  E8XJY3  50 aa hypothetical protein 0.0024 ●●●○○ -2.15 -2.14890815476316
Salmonella enterica Serovar Typhimurium ST4 74  STM474_1665  WP_000159242.1  E8XJY3  112 aa multidrug transporter 0.0024 ●●●○○ -2.15 -2.14890815476316
Vibrio parahaemolyticus RIMD 2210633  VPA_0285  BAC61628.1  Q87JG8  36 aa hypothetical protein 0.049 ●●●○○ -2.15 -2.14776570323071
Mycobacterium avium subsp. paratuberculosis K10  MAP_0711c  AAS03028.1  Q742X4  282 aa hypothetical protein 0.013 ●●●○○ -2.15 -2.14725104308995
Streptococcus pyogenes M1 5448  SP5448_07980  WP_010921916.1  173 aa metallophosphoesterase 0.038 ●●●○○ -2.15 -2.14684095849772
Vibrio parahaemolyticus RIMD 2210633  VP_0213  BAC58476.1  Q87T57  lpxM  329 aa putative lipid A biosynthesis (kdo)2-(lauroyl)-lipid IVA acyltransferase 0.035 ●●●○○ -2.15 -2.1466273567134
Escherichia coli O157:H7 str. EDL933  Z5052  AAG58772.1  235 aa putative LPS biosynthesis protein 0.018 ●●●○○ -2.15 -2.1463295427204
Salmonella enterica Serovar Typhimurium SL1344  SL1344_3879  CBW19969.1  A0A0H3NHU6  rffE  376 aa UDP-N-acetyl-D-glucosamine 2-epimerase 3.1e-5 ●●●○○ -2.15 -2.14631051379719
Mycobacterium avium subsp. paratuberculosis K10  MAP_1351c  AAS03668.1  Q740J9  lysX  1177 aa LysX 0.013 ●●●○○ -2.14 -2.1448090412394
Mycobacterium avium subsp. paratuberculosis K10  MAP_3742  AAS06292.1  Q73TH6  1535 aa hypothetical protein 0.013 ●●●○○ -2.14 -2.14459503726817
Campylobacter jejuni subsp. jejuni 81-176  CJJ81176_0055  WP_002868979.1  A0A0H3P989  recJ  523 aa single-stranded-DNA-specific exonuclease RecJ 0.021 ●●●○○ -2.14 -2.14386564845
Escherichia coli M12  CO715_22120  ATI08188.1  309 aa branched chain amino acid aminotransferase 2.1e-15 ●●●○○ -2.14 -2.14332999314984
Mycobacterium avium subsp. paratuberculosis K10  MAP_1023  AAS03340.1  Q741R4  lipU  357 aa LipU 0.013 ●●●○○ -2.14 -2.14304407617846
Salmonella enterica Serovar Typhimurium ST4 74  STM474_0762  WP_000114631.1  E8XAX2  sucD  289 aa succinate--CoA ligase subunit alpha 1.3e-15 ●●●○○ -2.14 -2.14238393483662
Haemophilus influenzae Rd KW20  HI_1444  NP_439596.1  P45208  metF  292 aa 5,10-methylenetetrahydrofolate reductase 0.034 ●●●○○ -2.14 -2.141953043433
Acinetobacter baumannii ATCC 17978  A1S_1240  ABO11668.2  248 aa putative transport protein 7.5e-5 ●●●○○ -2.14 -2.14146210730911
Vibrio parahaemolyticus RIMD 2210633  VP_0224  BAC58487.1  Q87T46  290 aa putative dTDP-4-dehydrorhamnose reductase 0.035 ●●●○○ -2.14 -2.1413743177847
Vibrio parahaemolyticus RIMD 2210633  VP_1022  BAC59285.1  Q87QX7  topA  876 aa DNA topoisomerase I 0.035 ●●●○○ -2.14 -2.1413743177847
Vibrio parahaemolyticus RIMD 2210633  VP_0735  BAC58998.1  Q87RP2  391 aa VisC-related protein 0.035 ●●●○○ -2.14 -2.1413743177847
Escherichia coli M12  CO715_07815  ATI05625.1  127 aa antitermination protein 7.1e-11 ●●●○○ -2.14 -2.1402003029361
Escherichia coli M12  CO715_02615  ATI04724.1  688 aa polyphosphate kinase 1.6e-6 ●●●○○ -2.14 -2.1397830109076
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2045  AIK80651.1  343 aa oxidoreductase, NAD-binding Rossmann fold family protein 1.6e-11 ●●●○○ -2.14 -2.13737861514228
Escherichia coli M12  CO715_08475  ATI05744.1  375 aa 23S rRNA (uracil(747)-C(5))-methyltransferase RlmC 3.4e-12 ●●●○○ -2.14 -2.13623602866537
Vibrio cholerae O1 biovar El Tor str. N16961  VC_2051  NP_231683.1  Q9KQE9  dsbE  184 aa thiol:disulfide interchange protein DsbE 4.8e-7 ●●●○○ -2.14 -2.13620790755356
Escherichia coli CFT073  c1219  AAN79679.1  A0A0H2V853  249 aa Putative Transposase 0.0026 ●●●○○ -2.14 -2.13585448563834
Haemophilus influenzae Rd KW20  HI_1615  NP_439757.1  P43849  purE  164 aa 5-(carboxyamino)imidazole ribonucleotide mutase 0.034 ●●●○○ -2.14 -2.13552362325196
Salmonella enterica Serovar Typhimurium ST4 74  STM474_1317  WP_000412161.1  E8XGB9  celA  106 aa PTS N,N'-diacetylchitobiose transporter subunit IIB 3.4e-21 ●●●○○ -2.13 -2.13443573628453
Salmonella enterica Serovar Typhimurium SL1344  SL1344_4350  CBW20436.1  A0A0H3NJ61  iolR  277 aa transcriptional regulator, repressor of myo-inositol metabolism 2.5e-5 ●●●○○ -2.13 -2.1341184671603
Vibrio parahaemolyticus RIMD 2210633  VP_2221  BAC60484.1  Q87ML0  ccmC  247 aa heme exporter protein C 0.036 ●●●○○ -2.13 -2.13381448495144
Escherichia coli M12  CO715_05685  ATI05262.1  99 aa DUF4222 domain-containing protein 3.8e-11 ●●●○○ -2.13 -2.13248040040889
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_5102  AIK83628.1  1195 aa lipid A export permease/ATP-binding protein MsbA <1e-323 ●●●○○ -2.13 -2.13240686367546
Escherichia coli O157:H7 str. EDL933  Z5116  AAG58829.1  305 aa sepQ 0.018 ●●●○○ -2.13 -2.13214097611345
Vibrio cholerae O1 biovar El Tor str. N16961  VC_1336  NP_230980.1  Q9KSC2  prpB  308 aa 2-methylisocitrate lyase 1.2e-11 ●●●○○ -2.13 -2.13093677947196
Escherichia coli M12  CO715_21860  ATI08142.1  453 aa U32 family peptidase 2.2e-15 ●●●○○ -2.13 -2.12955935620941
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