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Sorted by significance (p<0.05) and Fitness z-Scores (highest impact first):

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Pathogen Locus Protein UniProt Gene Length Product p-Value Fitness z-Score  Precise fitness z-Score
Salmonella enterica Serovar Typhimurium SL1344  SL1344_3671  CBW19764.1  A0A0H3NHE8  yibP  427 aa conserved hypothetical protein 0.02 ●●●●● -4.94 -4.94063633180321
Salmonella enterica Serovar Typhimurium SL1344  SL1344_0730  CBW16828.1  A0A0H3N961  tolB  430 aa tolB protein precursor 3.3e-23 ●●●●● -4.94 -4.93974006054048
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3699  WP_000192193.1  E8XEN5  301 aa dihydrodipicolinate synthase family protein 6.5e-11 ●●●●● -4.93 -4.93064405999643
Serratia marcescens Strain UMH9  BVG96_19795  ASL99724.1  305 aa DNA-binding transcriptional regulator OxyR 1.3e-11 ●●●●● -4.93 -4.92990945238529
Salmonella enterica Serovar Typhimurium SL1344  SL1344_2061  CBW18157.1  A0A0H3NEN6  cpsB2  479 aa mannose-1-phosphate guanylyltransferase 0.015 ●●●●● -4.92 -4.92329218580612
Acinetobacter baumannii ATCC 17978  A1S_0066  ABO10561.2  456 aa hypothetical protein 2.5e-43 ●●●●● -4.92 -4.91840030012013
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3300  WP_000145429.1  E8XAK0  hypO  372 aa hydrogenase 2 small subunit 7.2e-11 ●●●●● -4.91 -4.91421329687123
Serratia marcescens Strain UMH9  BVG96_19960  ASL99754.1  320 aa ATP-dependent 6-phosphofructokinase 3.9e-9 ●●●●● -4.91 -4.91303190784931
Salmonella enterica Serovar Typhimurium SL1344  SL1344_1334  CBW17430.1  A0A0H3NB70  sseC  484 aa Type III secretion system apparatus protein 0.015 ●●●●● -4.89 -4.89483527333749
Salmonella enterica Serovar Typhimurium SL1344  SL1344_0002  CBW16103.1  A0A0H3NCF4  thrA  820 aa aspartokinase I/homoserine dehydrogenase I 0.011 ●●●●● -4.89 -4.89399900999786
Streptococcus pyogenes M1 5448  SP5448_07830  WP_002985833.1  130 aa hypothetical protein 5.5e-7 ●●●●● -4.88 -4.88184329549208
Salmonella enterica Serovar Typhimurium SL1344  SL1344_4030  CBW20119.1  A0A0H3NI80  tpiA  255 aa triosephosphate isomerase 6.7e-21 ●●●●● -4.88 -4.88125558167751
Salmonella enterica Serovar Typhimurium SL1344  SL1344_3433  CBW19528.1  A0A0H3NMI2  crp  210 aa cyclic AMP receptor protein,catabolite gene activator 4.4e-22 ●●●●● -4.87 -4.86826835287423
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_5012  AIK83538.1  298 aa regulatory protein GalF <1e-323 ●●●●● -4.86 -4.86480031069644
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A0748  NP_233134.1  Q9KLJ6  glpB  436 aa anaerobic glycerol-3-phosphate dehydrogenase subunit B 9.2e-11 ●●●●● -4.86 -4.86086093042673
Salmonella enterica Serovar Typhimurium ST4 74  STM474_0493  WP_001280991.1  E8X859  hha  72 aa hemolysin expression modulator Hha 1.2e-10 ●●●●● -4.84 -4.83914205330117
Acinetobacter baumannii ATCC 17978  A1S_3152  ABO13549.2  410 aa D-3-phosphoglycerate dehydrogenase 3.9e-30 ●●●●● -4.83 -4.82930046793849
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3352  WP_000171739.1  E8XBC7  206 aa DUF1449 family protein 5.9e-24 ●●●●● -4.83 -4.82700804618048
Salmonella enterica Serovar Typhimurium SL1344  SL1344_2353  CBW18455.1  A0A0H3NE10  aroC  361 aa Chorismate synthase 8.9e-24 ●●●●● -4.83 -4.82607476201408
Vibrio parahaemolyticus RIMD 2210633  VPA_1356  BAC62699.1  Q87GG0  203 aa hypothetical protein 4.5e-6 ●●●●● -4.82 -4.81572129442156
Streptococcus pyogenes M1 5448  SP5448_06030  WP_003061805.1  216 aa amino acid ABC transporter permease 7.8e-7 ●●●●● -4.81 -4.81070439463529
Salmonella enterica Serovar Typhimurium ST4 74  STM474_0234  WP_000758966.1  E8XI23  hlpA  161 aa molecular chaperone Skp 1.1e-10 ●●●●● -4.8 -4.80137978984807
Mycobacterium avium subsp. paratuberculosis K10  MAP_0178c  AAS02495.1  Q745G4  dinB  400 aa hypothetical protein 1.3e-6 ●●●●● -4.8 -4.79585223788938
Salmonella enterica Serovar Typhimurium SL1344  SL1344_3841  CBW19932.1  A0A0H3NU81  gidA  629 aa glucose inhibited division protein 0.017 ●●●●● -4.79 -4.78972214769695
Salmonella enterica Serovar Typhimurium SL1344  SL1344_0089  CBW16191.1  A0A0H3N8Y9  apaH  282 aa bis(5'-nucleosyl)-tetraphosphatase 4.8e-18 ●●●●● -4.79 -4.78731782819054
Salmonella enterica Serovar Typhimurium ST4 74  STM474_4182  WP_000003520.1  E8XJI6  hemN  457 aa oxygen-independent coproporphyrinogen III oxidase 1.7e-10 ●●●●● -4.78 -4.78390186909166
Mycobacterium avium subsp. paratuberculosis K10  MAP_1647  AAS03964.1  Q73ZF6  fadD31  612 aa FadD31 1.4e-6 ●●●●● -4.78 -4.77801712443661
Salmonella enterica Serovar Typhimurium SL1344  SL1344_3321  CBW19417.1  A0A0H3NMA6  degS  356 aa serine protease 8.7e-28 ●●●●● -4.78 -4.77543302113135
Serratia marcescens Strain UMH9  BVG96_18955  ASL99574.1  366 aa 3-dehydroquinate synthase 1.3e-9 ●●●●● -4.78 -4.77531410114099
Salmonella enterica Serovar Typhimurium SL1344  SL1344_3810  CBW19901.1  A0A0H3NU44  thdF  458 aa thiophene and furan oxidation protein 0.023 ●●●●● -4.77 -4.76529472937173
Salmonella enterica Serovar Typhimurium SL1344  SL1344_3683  CBW19777.1  A0A0H3NJ35  rfaJ  336 aa lipopolysaccharide 1,2-glucosyltransferase 0.017 ●●●●● -4.76 -4.75616018459602
Vibrio parahaemolyticus RIMD 2210633  VPA_1366  BAC62709.1  Q87GF0  152 aa hypothetical protein 6.1e-6 ●●●●● -4.76 -4.75502249123051
Serratia marcescens Strain UMH9  BVG96_13140  ASL98514.1  216 aa DNA-binding response regulator 1.2e-7 ●●●●● -4.74 -4.74361934445599
Salmonella enterica Serovar Typhimurium ST4 74  STM474_4190  WP_000282794.1  E8XJJ4  291 aa membrane protein 1.1e-21 ●●●●● -4.74 -4.7410976584538
Haemophilus influenzae Rd KW20  HI_0812  NP_438972.1  P44878  galU  295 aa glucosephosphate uridylyltransferase 4.6e-6 ●●●●● -4.73 -4.73219139252888
Acinetobacter baumannii ATCC 17978  A1S_1190  ABO11620.2  A3M3X6  pyrB  338 aa aspartate carbamoyltransferase catalytic subunit 3.9e-101 ●●●●● -4.73 -4.72746903700773
Vibrio parahaemolyticus RIMD 2210633  VP_0616  BAC58879.1  Q87S08  guaB  490 aa inosine-5'-monophosphate dehydrogenase 5.0e-6 ●●●●● -4.72 -4.72377927795506
Salmonella enterica Serovar Typhimurium ST4 74  STM474_2079  WP_000532847.1  E8XB66  329 aa integrase 2.7e-10 ●●●●● -4.72 -4.7221185748826
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3206  AIK81774.1  309 aa branched-chain amino acid aminotransferase <1e-323 ●●●●● -4.72 -4.71532681272439
Salmonella enterica Serovar Typhimurium SL1344  SL1344_2903  CBW19002.1  A0A0H3NR39  rpoS  330 aa RNA polymerase sigma subunit RpoS (sigma-38) 1.9e-17 ●●●●● -4.71 -4.71245548351813
Acinetobacter baumannii ATCC 17978  A1S_0064  ABO10559.2  A3M0W5  pgi  556 aa putative phosphoglucose isomerase 5.0e-61 ●●●●● -4.71 -4.71053589748512
Mycobacterium avium subsp. paratuberculosis K10  MAP_3887c  AAS06437.1  Q73T32  361 aa hypothetical protein 2.0e-6 ●●●●● -4.71 -4.71012349001118
Mycobacterium avium subsp. paratuberculosis K10  MAP_4099  AAS06649.1  Q73SH5  339 aa hypothetical protein 2.1e-6 ●●●●● -4.7 -4.69644584106096
Salmonella enterica Serovar Typhimurium SL1344  SL1344_0612  CBW16712.1  A0A0H3N9D7  citC  358 aa [citrate (pro-3S)-lyase] ligase 0.037 ●●●●● -4.68 -4.68054587454505
Streptococcus pyogenes M1 5448  SP5448_05610  WP_010922267.1  469 aa dipeptidase PepV 8.6e-6 ●●●●● -4.68 -4.67900129440041
Vibrio parahaemolyticus RIMD 2210633  VP_2350  BAC60613.1  Q87MA7  nqrB  414 aa sodium-translocating NADH-quinone reductase, subunit B 6.2e-6 ●●●●● -4.68 -4.67801211648637
Mycobacterium avium subsp. paratuberculosis K10  MAP_2292  AAS04609.1  Q73XL7  773 aa hypothetical protein 2.4e-6 ●●●●● -4.67 -4.67194098726428
Mycobacterium avium subsp. paratuberculosis K10  MAP_2562  AAS04879.1  Q73WU8  225 aa hypothetical protein 2.5e-6 ●●●●● -4.66 -4.66399729768069
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3398  WP_000548370.1  E8XC61  tdcB  329 aa bifunctional threonine ammonia-lyase/L-serine ammonia-lyase TdcB 3.2e-20 ●●●●● -4.66 -4.66242233331953
Vibrio parahaemolyticus RIMD 2210633  VPA_1352  BAC62695.1  Q87GG4  137 aa hypothetical protein 9.5e-6 ●●●●● -4.66 -4.65909941038436
Salmonella enterica Serovar Typhimurium SL1344  SL1344_3750  CBW19841.1  A0A0H3NN41  157 aa hypothetical phosphoenolpyruvate-dependent sugar phosphotransferase system, eiia 2 0.038 ●●●●● -4.65 -4.65499734295929
Salmonella enterica Serovar Typhimurium SL1344  SL1344_1029  CBW17125.1  A0A0H3NBV1  pipC  113 aa cell invasion protein 0.015 ●●●●● -4.65 -4.65498805977057
Streptococcus pyogenes M1 5448  SP5448_05015  WP_009880616.1  520 aa glutamine-hydrolyzing GMP synthase 1.1e-5 ●●●●● -4.65 -4.65112253595653
Salmonella enterica Serovar Typhimurium ST4 74  STM474_2171  WP_001521643.1  E8XC40  rfbU  353 aa glycosyltransferase family 1 protein 1.0e-13 ●●●●● -4.64 -4.64402490508727
Salmonella enterica Serovar Typhimurium SL1344  SL1344_2466  CBW18568.1  A0A0H3NFX4  737 aa hypothetical membrane protein 0.028 ●●●●● -4.64 -4.6419354371015
Acinetobacter baumannii ATCC 17978  A1S_1191  ABO11621.1  242 aa aspartate carbamoyltransferase non-catalytic chain 6.1e-51 ●●●●● -4.64 -4.63822471922111
Serratia marcescens Strain UMH9  BVG96_00920  ASL96254.1  325 aa 23S rRNA pseudouridine(1911/1915/1917) synthase 2.2e-9 ●●●●● -4.63 -4.63432673155084
Salmonella enterica Serovar Typhimurium SL1344  SL1344_3962  CBW20052.1  A0A0H3NJU8  ompL  230 aa conserved hypothetical protein 0.049 ●●●●● -4.63 -4.62600814509194
Haemophilus influenzae Rd KW20  HI_0523  NP_438681.2  P44011  346 aa heptosyltransferase-like protein 7.6e-6 ●●●●● -4.63 -4.62550000302327
Salmonella enterica Serovar Typhimurium ST4 74  STM474_0959  WP_001292799.1  E8XCS9  pflB  760 aa formate C-acetyltransferase 4.7e-11 ●●●●● -4.62 -4.61869408106897
Haemophilus influenzae Rd KW20  HI_0428  NP_438589.1  P44707  dsbB  177 aa disulfide bond formation protein B 7.9e-6 ●●●●● -4.62 -4.61804186956817
Serratia marcescens Strain UMH9  BVG96_03830  ASL96782.1  217 aa MarR family transcriptional regulator 3.9e-7 ●●●●● -4.62 -4.61708005489758
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3515  AIK82071.1  143 aa rhodanese-like domain protein <1e-323 ●●●●● -4.61 -4.61146883079563
Salmonella enterica Serovar Typhimurium SL1344  SL1344_3679  CBW19773.1  A0A0H3NHD8  rfaL  404 aa O-antigen ligase 0.015 ●●●●● -4.61 -4.61005161676042
Salmonella enterica Serovar Typhimurium SL1344  SL1344_1355  CBW17451.1  A0A0H3NKY1  ssaT  259 aa Type III secretion system apparatus 0.037 ●●●●● -4.61 -4.61003109907448
Acinetobacter baumannii ATCC 17978  A1S_0033  ABO10528.2  136 aa putative signal peptide 1.7e-38 ●●●●● -4.6 -4.60437408672973
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3061  AIK81646.1  549 aa phosphoglucose isomerase family protein 8.9e-7 ●●●●● -4.6 -4.60199515287896
Salmonella enterica Serovar Typhimurium ST4 74  STM474_4456  WP_000527217.1  E8X9R1  5559 aa membrane protein 2.5e-30 ●●●●● -4.6 -4.60172092020126
Vibrio parahaemolyticus RIMD 2210633  VP_0847  BAC59110.1  Q87RF0  941 aa 2-oxoglutarate dehydrogenase, E1 component 9.1e-6 ●●●●● -4.59 -4.59279895662961
Vibrio parahaemolyticus RIMD 2210633  VPA_0001  BAC61344.1  Q87K97  656 aa conserved hypothetical protein 1.3e-5 ●●●●● -4.59 -4.5916635569117
Salmonella enterica Serovar Typhimurium SL1344  SL1344_0182  CBW16284.1  A0A0H3N842  panC  284 aa Pantoate--beta-alanine ligase 0.049 ●●●●● -4.59 -4.59079957222569
Serratia marcescens Strain UMH9  BVG96_05475  ASM00477.1  359 aa porin OmpA 0.00032 ●●●●● -4.59 -4.58962189478579
Salmonella enterica Serovar Typhimurium SL1344  SL1344_4494  CBW20583.1  A0A0H3NLC5  deoC  265 aa deoxyribose-phosphate aldolase 1.1e-18 ●●●●● -4.59 -4.58654376502988
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3223  WP_000098655.1  E8X9P7  tktA  663 aa transketolase 8.1e-10 ●●●●● -4.58 -4.58337111260973
Salmonella enterica Serovar Typhimurium SL1344  SL1344_3514  CBW19608.1  A0A0H3NT84  253 aa conserved hypothetical protein 0.027 ●●●●● -4.58 -4.57940452353037
Salmonella enterica Serovar Typhimurium ST4 74  STM474_4540  WP_001192954.1  E8XAM2  frdA  596 aa fumarate reductase (quinol) flavoprotein subunit 8.4e-10 ●●●●● -4.58 -4.57818622820215
Acinetobacter baumannii ATCC 17978  A1S_2253  ABO12676.2  A3M6Y2  pyrD  334 aa dihydroorotate oxydase 8.4e-34 ●●●●● -4.57 -4.56713366583662
Salmonella enterica Serovar Typhimurium SL1344  SL1344_3834  CBW19925.1  A0A0H3NNA2  atpA  513 aa ATP synthase alpha subunit 5.8e-17 ●●●●● -4.56 -4.5622715235807
Salmonella enterica Serovar Typhimurium ST4 74  STM474_1707  WP_001146150.1  E8XKQ7  sapC  296 aa peptide ABC transporter permease SapC 9.9e-10 ●●●●● -4.56 -4.55975124053259
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3273  WP_001275362.1  E8XAH3  227 aa LuxR family transcriptional regulator 7.4e-10 ●●●●● -4.55 -4.55110676609259
Salmonella enterica Serovar Typhimurium ST4 74  STM474_0470  WP_000130314.1  E8XKN7  clpX  423 aa ATP-dependent Clp protease ATP-binding subunit ClpX 7.5e-10 ●●●●● -4.55 -4.54856274764975
Salmonella enterica Serovar Typhimurium ST4 74  STM474_4778  WP_001112032.1  E8XDA6  stjC  235 aa fimbrial protein 5.7e-25 ●●●●● -4.55 -4.54823622124762
Salmonella enterica Serovar Typhimurium SL1344  SL1344_2416  CBW18518.1  A0A0H3NE25  425 aa conserved hypothetical protein 0.038 ●●●●● -4.55 -4.54639288583018
Serratia marcescens Strain UMH9  BVG96_01810  ASL96418.1  663 aa cytochrome ubiquinol oxidase subunit I 4.7e-9 ●●●●● -4.55 -4.54537929372741
Escherichia coli M12  CO715_02760  ATI04753.1  232 aa esterase 1.5e-12 ●●●●● -4.54 -4.54317644904024
Mycobacterium avium subsp. paratuberculosis K10  MAP_2549c  AAS04866.1  Q73WW1  174 aa hypothetical protein 4.3e-6 ●●●●● -4.54 -4.54254207197347
Salmonella enterica Serovar Typhimurium SL1344  SL1344_4219  CBW20306.1  A0A0H3NIJ1  gltP  436 aa proton glutamate symport protein 1.2e-15 ●●●●● -4.54 -4.54061229383513
Salmonella enterica Serovar Typhimurium ST4 74  STM474_0416  WP_000893645.1  E8XKI3  phoR  431 aa phosphate regulon sensor histidine kinase PhoR 2.4e-6 ●●●●● -4.52 -4.52123743208362
Salmonella enterica Serovar Typhimurium SL1344  SL1344_3092  CBW19191.1  A0A0H3NLY8  441 aa hypothetical hydrolase 0.033 ●●●●● -4.52 -4.51819272512248
Mycobacterium avium subsp. paratuberculosis K10  MAP_0662c  AAS02979.1  Q743C3  166 aa hypothetical protein 4.8e-6 ●●●●● -4.52 -4.51804506201926
Mycobacterium avium subsp. paratuberculosis K10  MAP_2561  AAS04878.1  Q73WU9  547 aa hypothetical protein 4.8e-6 ●●●●● -4.52 -4.51780769565494
Salmonella enterica Serovar Typhimurium ST4 74  STM474_2170  WP_000705151.1  E8XC39  rfbN  314 aa O antigen biosynthesis rhamnosyltransferase RfbN 1.9e-16 ●●●●● -4.52 -4.51620501432402
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3346  WP_000460259.1  E8XBC1  assT  598 aa aryl-sulfate sulfotransferase 4.6e-21 ●●●●● -4.51 -4.51495795064494
Salmonella enterica Serovar Typhimurium ST4 74  STM474_0192  WP_000150773.1  E8XHY1  folK  159 aa 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase 1.0e-9 ●●●●● -4.51 -4.50663780954099
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4417  AIK82960.1  135 aa marR family protein <1e-323 ●●●●● -4.5 -4.50393620481313
Mycobacterium avium subsp. paratuberculosis K10  MAP_0582  AAS02899.1  Q743K3  bpoA  261 aa BpoA 5.2e-6 ●●●●● -4.5 -4.50285467529873
Mycobacterium avium subsp. paratuberculosis K10  MAP_2661  AAS04978.1  Q73WJ9  metE  756 aa MetE 5.3e-6 ●●●●● -4.5 -4.49954790807532
Serratia marcescens Strain UMH9  BVG96_04525  ASL96911.1  746 aa acetylneuraminic acid synthetase 1.7e-9 ●●●●● -4.5 -4.49667418928932
Salmonella enterica Serovar Typhimurium SL1344  SL1344_3331  CBW19427.1  A0A0H3NMB1  mdh  312 aa malate dehydrogenase 0.038 ●●●●● -4.49 -4.48996728347483
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A0328  NP_232724.1  Q9K3D3  132 aa biphenyl-2,3-diol 1,2-dioxygenase 1.5e-14 ●●●●● -4.49 -4.48730355066992
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