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Sorted by significance (p<0.05) and Fitness z-Scores (highest impact first):

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Pathogen Locus Protein UniProt Gene Length Product p-Value Fitness z-Score  Precise fitness z-Score
Vibrio parahaemolyticus RIMD 2210633  VP_3001  BAC61264.1  Q87KH6  108 aa thioredoxin 0.016 ●●●○○ -2.47 -2.47433832109031
Campylobacter jejuni subsp. jejuni 81-176  CJJ81176_0480  WP_002868796.1  A0A0H3PIX5  175 aa hypothetical protein 0.0098 ●●●○○ -2.47 -2.46922628904
Salmonella enterica Serovar Typhimurium ST4 74  STM474_0590  WP_000192437.1  E8X941  apeE  656 aa autotransporter domain-containing esterase 3.0e-13 ●●●○○ -2.46 -2.46498270830235
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3937  WP_000131288.1  E8XGW1  mgtB  908 aa magnesium-translocating P-type ATPase 2.4e-6 ●●●○○ -2.46 -2.46458569583227
Acinetobacter baumannii ATCC 17978  A1S_1818  ABO12245.2  153 aa MaoC-like dehydratase 3.8e-10 ●●●○○ -2.46 -2.46297005418691
Salmonella enterica Serovar Typhimurium SL1344  SL1344_3468  CBW19563.1  A0A0H3NIL4  envZ  411 aa two-component sensor kinase EnvZ 8.8e-6 ●●●○○ -2.46 -2.46232018481181
Streptococcus pyogenes M1 5448  SP5448_08325  WP_010922662.1  565 aa PTS lactose transporter subunit IIBC 0.01 ●●●○○ -2.46 -2.46215932986298
Salmonella enterica Serovar Typhimurium ST4 74  STM474_0645  WP_000467874.1  E8X996  citC  358 aa [citrate (pro-3S)-lyase] ligase 8.6e-17 ●●●○○ -2.46 -2.46162608331926
Streptococcus pyogenes M1 5448  SP5448_03550  WP_002985387.1  77 aa hypothetical protein 0.02 ●●●○○ -2.46 -2.46119799336491
Salmonella enterica Serovar Typhimurium ST4 74  STM474_4194  WP_000064888.1  E8XJJ8  yihO  473 aa MFS transporter 5.0e-7 ●●●○○ -2.46 -2.46096647157007
Streptococcus pyogenes M1 5448  SP5448_03265  WP_010922498.1  214 aa DUF1027 domain-containing protein 0.0093 ●●●○○ -2.46 -2.45927532036878
Acinetobacter baumannii ATCC 17978  A1S_2587  ABO13004.2  A3M7W0  ruvA  199 aa holliday junction helicase subunit A 1.7e-17 ●●●○○ -2.46 -2.45838437916872
Vibrio parahaemolyticus RIMD 2210633  VPA_0581  BAC61924.1  Q87IM5  102 aa hypothetical protein 0.024 ●●●○○ -2.46 -2.4580341197913
Vibrio parahaemolyticus RIMD 2210633  VP_0984  BAC59247.1  Q87R14  kdsB  251 aa 3-deoxy-manno-octulosonate cytidylyltransferase 0.017 ●●●○○ -2.46 -2.4580200574841
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3643  WP_000493569.1  E8XEH9  nirC  269 aa nitrite transporter NirC 1.2e-17 ●●●○○ -2.46 -2.45764301833419
Escherichia coli O157:H7 str. EDL933  Z5135  AAG58847.1  217 aa escR 0.0087 ●●●○○ -2.46 -2.45693187450184
Acinetobacter baumannii ATCC 17978  A1S_0237  ABO10712.2  348 aa D-alanyl-D-alanine endopeptidase penicillin-binding protein 7 and penicillin-binding protein 8 1.3e-26 ●●●○○ -2.46 -2.45631391085133
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0550  NP_230201.1  Q9KUH1  597 aa oxaloacetate decarboxylase 6.6e-12 ●●●○○ -2.46 -2.45584476921025
Streptococcus pyogenes M1 5448  SP5448_08740  WP_002982472.1  83 aa hypothetical protein 0.0017 ●●●○○ -2.46 -2.45542997437653
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2327  AIK80931.1  447 aa ubiquinone oxidoreductase, Na(+)-translocating, A subunit 0.0078 ●●●○○ -2.45 -2.4530911910935
Salmonella enterica Serovar Typhimurium ST4 74  STM474_2784  WP_001212379.1  E8XID8  yfiR  172 aa YfiR family protein 1.6e-6 ●●●○○ -2.45 -2.45187121273637
Campylobacter jejuni subsp. jejuni 81-176  CJJ81176_0890  WP_002857013.1  A0A0H3PHG5  flhA  724 aa flagellar biosynthesis protein FlhA 0.01 ●●●○○ -2.45 -2.45139920733
Salmonella enterica Serovar Typhimurium ST4 74  STM474_0629  WP_000887644.1  E8X980  ahpF  521 aa alkyl hydroperoxide reductase subunit F 1.3e-16 ●●●○○ -2.45 -2.45122573881118
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2596  AIK81193.1  264 aa putative DNase 9.7e-5 ●●●○○ -2.45 -2.44851072895891
Haemophilus influenzae Rd KW20  HI_0037  NP_438210.2  P44474  mreB  351 aa rod shape-determining protein MreB 0.017 ●●●○○ -2.45 -2.44653177084547
Haemophilus influenzae Rd KW20  HI_1130  NP_439288.1  P45057  rsmH  321 aa S-adenosyl-methyltransferase MraW 0.017 ●●●○○ -2.45 -2.44653177084547
Mycobacterium avium subsp. paratuberculosis K10  MAP_0724  AAS03041.1  Q742W1  fadA6  384 aa FadA6_2 0.0066 ●●●○○ -2.45 -2.44538661435484
Campylobacter jejuni subsp. jejuni 81-176  CJJ81176_0638  WP_002868905.1  A0A0H3PJ52  392 aa hypothetical protein 0.01 ●●●○○ -2.45 -2.44533714945
Campylobacter jejuni subsp. jejuni 81-176  CJJ81176_1119  WP_002869042.1  A0A0H3PH62  691 aa ATP-dependent DNA helicase 0.01 ●●●○○ -2.44 -2.44464329074
Serratia marcescens Strain UMH9  BVG96_04660  ASL96935.1  468 aa phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating) 0.035 ●●●○○ -2.44 -2.4443280471021
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3660  WP_001663100.1  E8XEJ6  mrcA  858 aa peptidoglycan glycosyltransferase/peptidoglycan DD-transpeptidase MrcA 4.8e-19 ●●●○○ -2.44 -2.44430965334277
Acinetobacter baumannii ATCC 17978  A1S_3151  ABO13548.2  469 aa putative FAD/FMN-containing dehydrogenase 1.9e-28 ●●●○○ -2.44 -2.44318464628503
Salmonella enterica Serovar Typhimurium SL1344  SL1344_3710  CBW19804.1  A0A0H3NN06  recG  693 aa ATP-dependent DNA helicase 2.6e-8 ●●●○○ -2.44 -2.44310886754706
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3204  AIK81771.1  296 aa bacterial regulatory helix-turn-helix, lysR family protein <1e-323 ●●●○○ -2.44 -2.44195267066963
Vibrio parahaemolyticus RIMD 2210633  VP_1048  BAC59311.1  Q87QV1  ruvC  173 aa crossover junction endodeoxyribonuclease RuvC 0.018 ●●●○○ -2.44 -2.43952201287561
Vibrio parahaemolyticus RIMD 2210633  VP_0833  BAC59096.1  O24755  fur  149 aa ferric uptake regulatory protein 0.018 ●●●○○ -2.44 -2.43952201287561
Acinetobacter baumannii ATCC 17978  A1S_2539  ABO12956.1  A3M7R2  dapD  273 aa putative tetrahydropyridine-2-carboxylate N-succinyltransferase 6.4e-8 ●●●○○ -2.44 -2.43805448707164
Acinetobacter baumannii ATCC 17978  A1S_1861  ABO12288.1  133 aa benzoate dioxygenase large subunit 1.2e-38 ●●●○○ -2.44 -2.4371806926176
Vibrio parahaemolyticus RIMD 2210633  VP_0403  BAC58666.1  Q87SL9  111 aa hypothetical protein 0.018 ●●●○○ -2.43 -2.43455886734478
Salmonella enterica Serovar Typhimurium ST4 74  STM474_0519  WP_000083899.1  E8X885  copA  833 aa copper-exporting P-type ATPase CopA 0.049 ●●●○○ -2.43 -2.43451415573052
Streptococcus pyogenes M1 5448  SP5448_07060  WP_011285452.1  187 aa energy-coupled thiamine transporter ThiT 0.017 ●●●○○ -2.43 -2.4342805714191
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3267  WP_000982337.1  E8XAG7  441 aa acetyl-CoA hydrolase/transferase family protein 1.0e-14 ●●●○○ -2.43 -2.43342468381642
Acinetobacter baumannii ATCC 17978  A1S_2122  ABO12549.2  306 aa transcriptional regulator 3.5e-18 ●●●○○ -2.43 -2.43268594237515
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0849  NP_230496.1  P0C6Q0  ratA  146 aa hypothetical protein 5.0e-12 ●●●○○ -2.43 -2.43200170351751
Escherichia coli M12  CO715_09615  ATI05941.1  241 aa glutamate/aspartate transport ATP-binding protein GltL 1.1e-18 ●●●○○ -2.43 -2.43084420078477
Acinetobacter baumannii ATCC 17978  A1S_0610  ABO11059.2  276 aa pyrroline-5-carboxylate reductase 5.2e-25 ●●●○○ -2.43 -2.42954441027613
Acinetobacter baumannii ATCC 17978  A1S_3202  ABO13595.2  466 aa UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase 1.9e-6 ●●●○○ -2.43 -2.42941066509041
Salmonella enterica Serovar Typhimurium ST4 74  STM474_0389  WP_000950242.1  E8XJS3  yaiv  207 aa hydrogen peroxide resistance inhibitor IprA 3.3e-13 ●●●○○ -2.43 -2.42870973145567
Campylobacter jejuni subsp. jejuni 81-176  CJJ81176_1012  WP_002854006.1  A1VZY2  argF  306 aa ornithine carbamoyltransferase 0.011 ●●●○○ -2.43 -2.42862683718
Escherichia coli CFT073  c1789  AAN80255.1  A0A0H2V719  ycjU  219 aa Putative beta-phosphoglucomutase 0.028 ●●●○○ -2.43 -2.42794949137612
Escherichia coli CFT073  c2511  AAN80966.1  A0A0H2V8L6  260 aa Insertion sequence ATP-binding protein 0.03 ●●●○○ -2.43 -2.4278188343889
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3470  WP_000476475.1  E8XCC7  yrbC  211 aa phospholipid-binding protein MlaC 0.00016 ●●●○○ -2.43 -2.4256824688524
Salmonella enterica Serovar Typhimurium ST4 74  STM474_4389  WP_000084331.1  E8X8V7  151 aa hypothetical protein 4.2e-34 ●●●○○ -2.43 -2.42505713083626
Salmonella enterica Serovar Typhimurium ST4 74  STM474_4035  WP_000741630.1  E8XHU4  pstC  319 aa phosphate ABC transporter permease PstC 4.4e-6 ●●●○○ -2.42 -2.42418452215367
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0633  NP_230282.1  P0C6Q6  ompU  350 aa outer membrane protein OmpU 1.7e-10 ●●●○○ -2.42 -2.42387175216262
Streptococcus pyogenes M1 5448  SP5448_08365  WP_011285716.1  60 aa integrase 0.013 ●●●○○ -2.42 -2.42370586994039
Streptococcus pyogenes M1 5448  SP5448_08365  WP_010922665.1  111 aa type II toxin-antitoxin system RelE/ParE family toxin 0.013 ●●●○○ -2.42 -2.42370586994039
Streptococcus pyogenes M1 5448  SP5448_02735  WP_010922555.1  447 aa DEAD/DEAH box helicase 0.032 ●●●○○ -2.42 -2.42370586994039
Acinetobacter baumannii ATCC 17978  A1S_0686  ABO11130.2  227 aa ATP-phosphoribosyltransferase 5.4e-38 ●●●○○ -2.42 -2.42366804619139
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3986  AIK82534.1  83 aa hdeA/HdeB family protein 5.7e-6 ●●●○○ -2.42 -2.42326339820509
Acinetobacter baumannii ATCC 17978  A1S_2256  ABO12679.2  151 aa putative phosphohistidine phosphatase 6.4e-16 ●●●○○ -2.42 -2.41996873683326
Salmonella enterica Serovar Typhimurium SL1344  SL1344_2503  CBW18604.1  A0A0H3NG18  iscA  107 aa conserved hypothetical protein 1.2e-7 ●●●○○ -2.41 -2.41477407036721
Acinetobacter baumannii ATCC 17978  A1S_3221  ABO13612.2  553 aa putative transport protein 3.1e-17 ●●●○○ -2.41 -2.41329332163519
Vibrio cholerae O1 biovar El Tor str. N16961  VC_1816  NP_231450.1  Q9KR31  71 aa hypothetical protein 1.1e-9 ●●●○○ -2.41 -2.41051403654669
Streptococcus pyogenes M1 5448  SP5448_04560  WP_009880256.1  136 aa DUF5072 domain-containing protein 0.014 ●●●○○ -2.41 -2.40928582246942
Mycobacterium avium subsp. paratuberculosis K10  MAP_0921c  AAS03238.1  Q742B6  226 aa hypothetical protein 0.0072 ●●●○○ -2.41 -2.40813181949803
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0647  NP_230296.1  Q9KU76  pnp  709 aa polynucleotide phosphorylase 2.7e-15 ●●●○○ -2.4 -2.40455701052286
Vibrio parahaemolyticus RIMD 2210633  VP_1169  BAC59432.1  Q87QI0  295 aa peptide ABC transporter, permease protein 0.019 ●●●○○ -2.4 -2.40130155936544
Vibrio parahaemolyticus RIMD 2210633  VP_0414  BAC58677.1  Q87SK9  cca  406 aa tRNA nucleotidyltransferase 0.02 ●●●○○ -2.39 -2.39394431970836
Acinetobacter baumannii ATCC 17978  A1S_3172  ABO13569.2  701 aa hypothetical protein (SpoT) 6.1e-14 ●●●○○ -2.39 -2.3930499280815
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3288  WP_000475246.1  E8XAI8  352 aa methyl-accepting chemotaxis protein 5.6e-18 ●●●○○ -2.39 -2.39279593136633
Salmonella enterica Serovar Typhimurium ST4 74  STM474_2151  WP_000703998.1  E8XC20  sopA  782 aa SPI-1 type III secretion system effector HECT-type E3 ubiquitin transferase SopA 5.3e-6 ●●●○○ -2.39 -2.39237864017566
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0535  NP_230186.1  Q9KUI6  mutS  862 aa DNA mismatch repair protein MutS 1.3e-7 ●●●○○ -2.39 -2.3874977048271
Vibrio cholerae O1 biovar El Tor str. N16961  VC_2520  NP_232149.1  Q9KP56  267 aa ABC transporter ATP-binding protein 2.2e-9 ●●●○○ -2.39 -2.3869081032565
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0941  NP_230588.2  Q9KTG1  glyA1  416 aa serine hydroxymethyltransferase 4.7e-9 ●●●○○ -2.38 -2.38486725006738
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2839  AIK81428.1  332 aa fructose-1-6-bisphosphatase family protein 3.4e-8 ●●●○○ -2.38 -2.38413204663691
Mycobacterium avium subsp. paratuberculosis K10  MAP_0081  AAS02398.1  Q744Y6  438 aa hypothetical protein 0.0076 ●●●○○ -2.38 -2.38345961336321
Streptococcus pyogenes M1 5448  SP5448_03435  WP_010922485.1  553 aa DNA repair protein RecN 0.024 ●●●○○ -2.38 -2.38332973702167
Salmonella enterica Serovar Typhimurium ST4 74  STM474_2980  WP_000963438.1  E8XK81  hypF  746 aa carbamoyltransferase HypF 4.4e-6 ●●●○○ -2.38 -2.38204397547778
Vibrio parahaemolyticus RIMD 2210633  VP_2829  BAC61092.1  Q87KZ5  gpmI  510 aa phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent 0.02 ●●●○○ -2.38 -2.38154217931965
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3681  WP_000428721.1  E8XEL7  malQ  692 aa 4-alpha-glucanotransferase 5.0e-6 ●●●○○ -2.38 -2.38119274594368
Escherichia coli M12  CO715_11890  ATI06346.1  395 aa cystathionine beta-lyase MetC 2.2e-15 ●●●○○ -2.38 -2.38097780337929
Salmonella enterica Serovar Typhimurium ST4 74  STM474_2808  WP_001203445.1  E8XIG2  bamE  112 aa outer membrane protein assembly factor BamE 4.8e-18 ●●●○○ -2.38 -2.38079932297696
Vibrio cholerae O1 biovar El Tor str. N16961  VC_1253  NP_230898.1  Q9KSK3  142 aa hypothetical protein 5.9e-9 ●●●○○ -2.38 -2.38028621690426
Mycobacterium avium subsp. paratuberculosis K10  MAP_0188c  AAS02505.1  Q745H6  59 aa hypothetical protein 0.0077 ●●●○○ -2.38 -2.3798978990705
Acinetobacter baumannii ATCC 17978  A1S_0630  ABO11079.2  375 aa hypothetical protein 6.4e-37 ●●●○○ -2.38 -2.3784569018894
Salmonella enterica Serovar Typhimurium ST4 74  STM474_4051  WP_000116685.1  E8XIJ2  atpI  126 aa F0F1 ATP synthase subunit I 5.6e-6 ●●●○○ -2.38 -2.37812503183942
Streptococcus pyogenes M1 5448  SP5448_07240  WP_010922007.1  112 aa hypothetical protein 0.027 ●●●○○ -2.38 -2.37660038153521
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3191  AIK81759.1  367 aa undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase 6.9e-8 ●●●○○ -2.38 -2.37648763223533
Vibrio cholerae O1 biovar El Tor str. N16961  VC_1025  NP_230670.1  Q9KT80  170 aa molybdenum cofactor biosynthesis protein B 6.5e-10 ●●●○○ -2.38 -2.37538269723184
Escherichia coli CFT073  c1698  AAN80165.1  A0A0H2V6X7  ychK  314 aa Hypothetical protein ychK 0.028 ●●●○○ -2.37 -2.37395961884861
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0252  NP_229909.1  H9L4Q4  188 aa acetyltransferase 3.8e-9 ●●●○○ -2.37 -2.37361837737033
Serratia marcescens Strain UMH9  BVG96_19565  ASL99687.1  450 aa glutathione-disulfide reductase 0.0086 ●●●○○ -2.37 -2.37203721090235
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2647  AIK81241.1  44 aa hypothetical protein 0.031 ●●●○○ -2.37 -2.37121301751711
Mycobacterium avium subsp. paratuberculosis K10  MAP_3963  AAS06513.1  Q73SW0  umaA1  286 aa UmaA1 0.0079 ●●●○○ -2.37 -2.36992535821645
Acinetobacter baumannii ATCC 17978  A1S_1700  ABO12127.2  339 aa acetoin:26-dichlorophenolindophenol oxidoreductase beta subunit 2.2e-38 ●●●○○ -2.37 -2.36922037187633
Mycobacterium avium subsp. paratuberculosis K10  MAP_1542  AAS03859.1  Q73ZQ9  164 aa hypothetical protein 0.0079 ●●●○○ -2.37 -2.36891266032944
Salmonella enterica Serovar Typhimurium ST4 74  STM474_0044  WP_001116457.1  E8XG63  679 aa glycoside hydrolase family 31 protein 2.8e-18 ●●●○○ -2.37 -2.36827939958387
Salmonella enterica Serovar Typhimurium ST4 74  STM474_0101  WP_000035723.1  E8XH06  polB  783 aa DNA polymerase II 1.1e-6 ●●●○○ -2.37 -2.36816358097584
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A0551  NP_232941.1  Q9KM38  76 aa hypothetical protein 1.7e-14 ●●●○○ -2.37 -2.36594937774098
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