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Sorted by significance (p<0.05) and Fitness z-Scores (highest impact first):

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Pathogen Locus Protein UniProt Gene Length Product p-Value Fitness z-Score  Precise fitness z-Score
Streptococcus pyogenes M1 5448  SP5448_08045  WP_010921910.1  524 aa endolytic transglycosylase MltG 0.021 ○○○○○ 2.71 2.70694702023145
Streptococcus pyogenes M1 5448  SP5448_00760  WP_076640008.1  458 aa short-chain fatty acid transporter 0.0082 ○○○○○ 2.71 2.71079236622371
Acinetobacter baumannii ATCC 17978  A1S_0058  ABO10553.2  387 aa Glycosyltransferase 0.00015 ○○○○○ 2.71 2.71138160947129
Mycobacterium avium subsp. paratuberculosis K10  MAP_2823  AAS05140.1  Q73W37  333 aa hypothetical protein 0.0033 ○○○○○ 2.72 2.71662574009124
Streptococcus pyogenes M1 5448  SP5448_06680  WP_010922116.1  340 aa YegS/Rv2252/BmrU family lipid kinase 0.0016 ○○○○○ 2.72 2.71752172171017
Mycobacterium avium subsp. paratuberculosis K10  MAP_1670c  AAS03987.1  Q73ZD3  lppS  427 aa LppS_1 0.0031 ○○○○○ 2.73 2.73482717725348
Streptococcus pyogenes M1 5448  SP5448_04690  WP_002984449.1  185 aa signal peptidase I 0.012 ○○○○○ 2.74 2.7357871151734
Streptococcus pyogenes M1 5448  SP5448_03030  WP_010922526.1  307 aa ROK family protein 0.02 ○○○○○ 2.74 2.73867112466759
Streptococcus pyogenes M1 5448  SP5448_05425  WP_010922289.1  388 aa NADP-dependent malic enzyme 0.0093 ○○○○○ 2.74 2.74059379766372
Campylobacter jejuni subsp. jejuni 81-176  CJJ81176_0968  WP_002868960.1  A0A0H3P986  244 aa hypothetical protein 0.0048 ○○○○○ 2.75 2.74521612995
Escherichia coli M12  CO715_21035  ATI07994.1  341 aa beta-hexosaminidase 0.04 ○○○○○ 2.75 2.74670664280073
Campylobacter jejuni subsp. jejuni 81-176  CJJ81176_0911  WP_002856856.1  A0A0H3PA42  242 aa amino acid ABC transporter ATP-binding protein 0.0047 ○○○○○ 2.75 2.74913534243
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_1503  AIK80123.1  585 aa AAA domain protein <1e-323 ○○○○○ 2.76 2.75951288304607
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_1367  AIK79990.1  264 aa putative metallodependent hydrolase <1e-323 ○○○○○ 2.76 2.76118554532403
Mycobacterium avium subsp. paratuberculosis K10  MAP_3159  AAS05707.1  Q73V57  486 aa hypothetical protein 0.0028 ○○○○○ 2.77 2.76785869901092
Escherichia coli M12  CO715_22280  ATI08218.1  232 aa DTW domain-containing protein 5.3e-8 ○○○○○ 2.77 2.7700749963966
Mycobacterium avium subsp. paratuberculosis K10  MAP_0349  AAS02666.1  Q744J2  367 aa hypothetical protein 0.0028 ○○○○○ 2.77 2.77033829136859
Escherichia coli M12  CO715_19950  ATI07791.1  90 aa DNA-binding protein HU-beta 0.0029 ○○○○○ 2.77 2.77278739458183
Streptococcus pyogenes M1 5448  SP5448_09015  WP_011285757.1  631 aa endopeptidase 0.00019 ○○○○○ 2.77 2.77327923859792
Porphyromonas gingivalis ATCC 33277  PGN_0716  WP_012457723.1  B2RIP0  417 aa efflux RND transporter periplasmic adaptor subunit 8.1e-11 ○○○○○ 2.78 2.77504859813302
Mycobacterium avium subsp. paratuberculosis K10  MAP_3639c  AAS06189.1  Q73TS9  393 aa hypothetical protein 0.0028 ○○○○○ 2.78 2.77574721261599
Vibrio parahaemolyticus RIMD 2210633  VP_1769  BAC60032.1  Q87NU9  50 aa hypothetical protein 0.0073 ○○○○○ 2.78 2.77789258294569
Campylobacter jejuni subsp. jejuni 81-176  CJJ81176_1143  WP_002853816.1  A0A0H3P9U9  pglB  713 aa peptide-binding protein 0.0044 ○○○○○ 2.78 2.77804441119
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_1079  AIK79702.1  294 aa metallo-beta-lactamase superfamily protein <1e-323 ○○○○○ 2.78 2.78204136088273
Vibrio parahaemolyticus RIMD 2210633  VP_2255  BAC60518.1  Q87MJ5  101 aa polar flagellar rod protein FlaI 0.007 ○○○○○ 2.79 2.79236527646681
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4887  AIK83414.1  354 aa ada transcriptional dual regulator <1e-323 ○○○○○ 2.8 2.79687656423912
Porphyromonas gingivalis ATCC 33277  PGN_1122  WP_012458043.1  B2RJU6  845 aa NADP transhydrogenase subunit beta <1e-323 ○○○○○ 2.8 2.79714889230777
Streptococcus pyogenes M1 5448  SP5448_06175  WP_010922164.1  670 aa multifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/5'-nucleotidase/3'-nucleotidase 0.0013 ○○○○○ 2.8 2.804042006536
Streptococcus pyogenes M1 5448  SP5448_05675  WP_002989935.1  141 aa PTS sugar transporter subunit IIA 0.016 ○○○○○ 2.8 2.804042006536
Haemophilus influenzae Rd KW20  HI_0927  NP_439087.1  P43821  glyQ  302 aa glycine--tRNA ligase subunit alpha 0.0065 ○○○○○ 2.81 2.81001678188634
Acinetobacter baumannii ATCC 17978  A1S_2655  ABO13071.2  127 aa hypothetical protein 9.9e-41 ○○○○○ 2.81 2.81334667481738
Streptococcus pyogenes M1 5448  SP5448_03865  WP_010922436.1  747 aa DNA internalization-related competence protein ComEC/Rec2 0.0065 ○○○○○ 2.82 2.81653938101084
Acinetobacter baumannii ATCC 17978  A1S_1965  ABO12392.2  262 aa UDP-acetylglucosamine acyltransferase 1.1e-9 ○○○○○ 2.82 2.82375692826623
Escherichia coli M12  CO715_12085  ATI06382.1  134 aa protein GlcG 0.00014 ○○○○○ 2.82 2.82494889814405
Campylobacter jejuni subsp. jejuni 81-176  CJJ81176_1547  WP_002851141.1  A0A0H3P9P4  143 aa MerR family transcriptional regulator 0.0038 ○○○○○ 2.83 2.82895902102
Streptococcus pyogenes M1 5448  SP5448_04315  WP_002984240.1  278 aa sugar ABC transporter permease 0.009 ○○○○○ 2.83 2.83192076497988
Escherichia coli M12  CO715_09135  ATI05859.1  263 aa cell division protein CpoB 5.0e-5 ○○○○○ 2.84 2.83517255284224
Mycobacterium avium subsp. paratuberculosis K10  MAP_2620c  AAS04937.1  Q73WP0  narG  1230 aa NarG 0.0023 ○○○○○ 2.84 2.83764203495781
Porphyromonas gingivalis ATCC 33277  PGN_1893  WP_043876336.1  B2RM17  208 aa DNA-binding protein <1e-323 ○○○○○ 2.84 2.83884686031763
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_1089  AIK79712.1  175 aa type VI secretion lipofamily protein <1e-323 ○○○○○ 2.84 2.84160988012755
Escherichia coli M12  CO715_07535  ATI05579.1  231 aa nitrate reductase molybdenum cofactor assembly chaperone 1.9e-41 ○○○○○ 2.85 2.84518756152619
Streptococcus pyogenes M1 5448  SP5448_06685  WP_010922115.1  652 aa NAD-dependent DNA ligase LigA 0.014 ○○○○○ 2.85 2.85114749494117
Vibrio parahaemolyticus RIMD 2210633  VPA_1692  BAC63035.1  Q87FI7  52 aa hypothetical protein 0.0083 ○○○○○ 2.86 2.855407964695
Porphyromonas gingivalis ATCC 33277  PGN_0415  WP_012457493.1  B2RHT9  1324 aa DEAD/DEAH box helicase 1.8e-10 ○○○○○ 2.86 2.86137521092857
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4369  AIK82912.1  232 aa binding-protein-dependent transport system innermembrane component family protein <1e-323 ○○○○○ 2.87 2.87156563379056
Streptococcus pyogenes M1 5448  SP5448_03610  WP_010922469.1  114 aa HNH endonuclease 0.014 ○○○○○ 2.88 2.87614224389086
Streptococcus pyogenes M1 5448  SP5448_00690  WP_010921807.1  213 aa deoxynucleoside kinase 0.0019 ○○○○○ 2.88 2.88094892638118
Mycobacterium avium subsp. paratuberculosis K10  MAP_2033  AAS04350.1  Q73YC3  437 aa hypothetical protein 0.002 ○○○○○ 2.89 2.88548807669258
Escherichia coli M12  CO715_11980  ATI06363.1  82 aa hydrogenase-2 operon protein HybG 5.4e-6 ○○○○○ 2.9 2.89567989697441
Streptococcus pyogenes M1 5448  SP5448_01180  WP_010921869.1  427 aa sensor histidine kinase 0.016 ○○○○○ 2.9 2.89633031035022
Porphyromonas gingivalis ATCC 33277  PGN_0709  WP_004585221.1  B2RIN3  197 aa indolepyruvate oxidoreductase subunit beta <1e-323 ○○○○○ 2.9 2.89686439762065
Acinetobacter baumannii ATCC 17978  A1S_1514  ABO11941.2  A3M4U7  ruvC  181 aa holliday junction nuclease 3.8e-8 ○○○○○ 2.9 2.89877833083494
Escherichia coli M12  CO715_14995  ATI06904.1  195 aa transcriptional regulator 8.4e-6 ○○○○○ 2.9 2.90110469334488
Vibrio parahaemolyticus RIMD 2210633  VP_0090  BAC58353.1  Q87TH9  116 aa hypothetical protein 0.0046 ○○○○○ 2.94 2.942630548327
Streptococcus pyogenes M1 5448  SP5448_03040  WP_002988998.1  308 aa carbohydrate ABC transporter permease 0.0081 ○○○○○ 2.95 2.94824248124572
Streptococcus pyogenes M1 5448  SP5448_07805  WP_010921937.1  395 aa L-lactate oxidase 0.001 ○○○○○ 2.96 2.96073985572056
Vibrio parahaemolyticus RIMD 2210633  VPA_1235  BAC62578.1  Q87GT0  29 aa hypothetical protein 0.0061 ○○○○○ 2.96 2.96272659953308
Streptococcus pyogenes M1 5448  SP5448_05445  WP_002984738.1  357 aa ABC transporter substrate-binding protein 0.0091 ○○○○○ 2.97 2.97035322070121
Campylobacter jejuni subsp. jejuni 81-176  CJJ81176_1571  WP_002869224.1  Q0Q7H8  dmsB  218 aa dimethylsulfoxide reductase subunit B 0.0023 ○○○○○ 3 3.00032295072
Mycobacterium avium subsp. paratuberculosis K10  MAP_1930  AAS04247.1  Q73YM5  643 aa hypothetical protein 0.0014 ○○○○○ 3.01 3.00871986524295
Escherichia coli M12  CO715_14680  ATI06847.1  102 aa hypothetical protein 0.00025 ○○○○○ 3.01 3.01210437292528
Vibrio parahaemolyticus RIMD 2210633  VPA_0402  BAC61745.1  Q87J51  79 aa hypothetical protein 0.0052 ○○○○○ 3.01 3.01264016927412
Escherichia coli M12  CO715_07085  ATI05500.1  89 aa host cell division inhibitory peptide Kil 6.9e-20 ○○○○○ 3.01 3.01314760299652
Campylobacter jejuni subsp. jejuni 81-176  CJJ81176_0111  WP_002860571.1  A0A0H3P9K8  479 aa iron-sulfur cluster-binding protein 0.0022 ○○○○○ 3.01 3.01374870405
Escherichia coli M12  CO715_24140  ATI08529.1  141 aa heavy metal-responsive transcriptional regulator 1.3e-7 ○○○○○ 3.03 3.02858740805094
Mycobacterium avium subsp. paratuberculosis K10  MAP_3346c  AAS05896.1  Q73UM0  pvdS  292 aa PvdS 0.0013 ○○○○○ 3.04 3.04007550177219
Streptococcus pyogenes M1 5448  SP5448_07790  WP_010921939.1  235 aa DUF1275 domain-containing protein 0.004 ○○○○○ 3.05 3.05302815953478
Streptococcus pyogenes M1 5448  SP5448_07790  WP_011285405.1  59 aa hypothetical protein 0.004 ○○○○○ 3.05 3.05302815953478
Campylobacter jejuni subsp. jejuni 81-176  CJJ81176_1336  WP_009882893.1  Q7X518  pseD  654 aa DUF115 domain-containing protein 0.002 ○○○○○ 3.05 3.05360014416
Vibrio parahaemolyticus RIMD 2210633  VP_2439  BAC60701.1  Q87M20  257 aa putative hydrolase 0.0032 ○○○○○ 3.07 3.06593421670378
Escherichia coli M12  CO715_17540  ATI07363.1  237 aa hypothetical protein 7.2e-6 ○○○○○ 3.07 3.07010796488646
Acinetobacter baumannii ATCC 17978  A1S_0501  ABO10954.2  263 aa hypothetical protein 0.00059 ○○○○○ 3.08 3.07629072488795
Streptococcus pyogenes M1 5448  SP5448_01650  WP_010922643.1  99 aa YbaB/EbfC family nucleoid-associated protein 0.016 ○○○○○ 3.09 3.08763627346511
Escherichia coli M12  CO715_05405  ATI05214.1  323 aa tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB 0.00013 ○○○○○ 3.09 3.09347631848233
Vibrio parahaemolyticus RIMD 2210633  VP_1884  BAC60147.1  Q87NI4  61 aa hypothetical protein 0.0029 ○○○○○ 3.1 3.09736470685296
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_1314  AIK79937.1  397 aa zinc-binding dehydrogenase family protein <1e-323 ○○○○○ 3.12 3.11724298711814
Escherichia coli M12  CO715_02030  ATI04617.1  69 aa stress-induced protein 2.3e-7 ○○○○○ 3.12 3.12289540649142
Escherichia coli M12  CO715_07180  ATI05518.1  373 aa cupin domain-containing protein 0.0097 ○○○○○ 3.13 3.12685968076215
Porphyromonas gingivalis ATCC 33277  PGN_0320  WP_039417067.1  B2RHJ4  162 aa hypothetical protein 0.011 ○○○○○ 3.13 3.12991189473784
Streptococcus pyogenes M1 5448  SP5448_02400  WP_002983443.1  151 aa hypothetical protein 0.0064 ○○○○○ 3.14 3.13666443486642
Vibrio parahaemolyticus RIMD 2210633  VPA_0455  BAC61798.1  Q87J00  39 aa hypothetical protein 0.0035 ○○○○○ 3.14 3.14158457832237
Streptococcus pyogenes M1 5448  SP5448_05355  WP_002984696.1  223 aa GTP pyrophosphokinase family protein 0.0095 ○○○○○ 3.15 3.145316463349
Vibrio parahaemolyticus RIMD 2210633  VPA_0605  BAC61948.1  Q87IK1  132 aa hypothetical protein 0.0035 ○○○○○ 3.15 3.14693944245877
Campylobacter jejuni subsp. jejuni 81-176  CJJ81176_1256  WP_002856604.1  A0A0H3PBD5  399 aa MFS transporter 0.0014 ○○○○○ 3.15 3.15180138084
Acinetobacter baumannii ATCC 17978  A1S_1529  ABO11956.2  162 aa leucine-responsive regulatory protein 0.00011 ○○○○○ 3.17 3.17184124797244
Streptococcus pyogenes M1 5448  SP5448_07745  WP_010921948.1  210 aa hypothetical protein 0.0053 ○○○○○ 3.18 3.17607923128708
Vibrio parahaemolyticus RIMD 2210633  VPA_0206  BAC61549.1  Q87JP2  50 aa hypothetical protein 0.0031 ○○○○○ 3.18 3.1837290304111
Streptococcus pyogenes M1 5448  SP5448_00880  WP_011285365.1  571 aa cholesterol-dependent cytolysin streptolysin O 0.013 ○○○○○ 3.21 3.21164868171547
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_1402  AIK80024.1  123 aa msyB family protein <1e-323 ○○○○○ 3.21 3.21392705678758
Escherichia coli M12  CO715_10605  ATI06108.1  109 aa lysozyme inhibitor 1.3e-70 ○○○○○ 3.22 3.22388007738787
Vibrio parahaemolyticus RIMD 2210633  VPA_0010  BAC61353.1  Q87K88  69 aa hypothetical protein 0.0026 ○○○○○ 3.24 3.23521621966748
Porphyromonas gingivalis ATCC 33277  PGN_0406  WP_012457487.1  B2RHT0  767 aa alpha-1 2-mannosidase 0.003 ○○○○○ 3.24 3.23587410024531
Porphyromonas gingivalis ATCC 33277  PGN_0406  WP_080504396.1  B2RHT0  76 aa hypothetical protein 0.003 ○○○○○ 3.24 3.23587410024531
Escherichia coli M12  CO715_21105  ATI08005.1  319 aa hypothetical protein 0.007 ○○○○○ 3.24 3.2363988382428
Streptococcus pyogenes M1 5448  SP5448_01190  WP_002992035.1  119 aa ribonuclease P protein component 0.0021 ○○○○○ 3.25 3.24529545914774
Escherichia coli M12  CO715_22620  ATI08274.1  238 aa DNA-binding response regulator 3.3e-8 ○○○○○ 3.26 3.25914125379593
Streptococcus pyogenes M1 5448  SP5448_02300  WP_002988730.1  91 aa VRR-NUC domain-containing protein 0.0053 ○○○○○ 3.27 3.27413555408969
Streptococcus pyogenes M1 5448  SP5448_07390  WP_011285427.1  330 aa ATP-binding cassette domain-containing protein 6.9e-5 ○○○○○ 3.28 3.28086490957614
Escherichia coli M12  CO715_22945  ATI08331.1  383 aa hypothetical protein 2.9e-28 ○○○○○ 3.3 3.29648889034648
Escherichia coli M12  CO715_11240  ATI06226.1  206 aa hypothetical protein 9.9e-49 ○○○○○ 3.3 3.29815805846047
Retrieved entries 36,201–36,300 out of 36,363 total in 1889.5 ms (Link to these results)