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Sorted by significance (p<0.05) and Fitness z-Scores (highest impact first):

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Pathogen Locus Protein UniProt Gene Length Product p-Value Fitness z-Score  Precise fitness z-Score
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_5014  AIK83540.1  477 aa capsule assembly Wzi family protein <1e-323 ●●●●● -5.94 -5.93735055322209
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3141  AIK81712.1  133 aa transcriptional activator RfaH <1e-323 ●●●●● -5.9 -5.90252752903176
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_5096  AIK83622.1  54 aa hypothetical protein <1e-323 ●●●●● -5.84 -5.8396059200783
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3202  AIK81770.1  491 aa ketol-acid reductoisomerase <1e-323 ●●●●● -5.76 -5.76195381190226
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3832  AIK82382.1  156 aa arginine repressor <1e-323 ●●●●● -5.24 -5.23704426407011
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_5025  AIK83551.1  465 aa undecaprenyl-phosphate glucose phosphotransferase <1e-323 ●●●●● -5 -5.00083721662808
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_5012  AIK83538.1  298 aa regulatory protein GalF <1e-323 ●●●●● -4.86 -4.86480031069644
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3206  AIK81774.1  309 aa branched-chain amino acid aminotransferase <1e-323 ●●●●● -4.72 -4.71532681272439
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3515  AIK82071.1  143 aa rhodanese-like domain protein <1e-323 ●●●●● -4.61 -4.61146883079563
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3061  AIK81646.1  549 aa phosphoglucose isomerase family protein 8.9e-7 ●●●●● -4.6 -4.60199515287896
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4417  AIK82960.1  135 aa marR family protein <1e-323 ●●●●● -4.5 -4.50393620481313
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4811  AIK83338.1  505 aa amidophosphoribosyltransferase <1e-323 ●●●●● -4.38 -4.38303093695164
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4619  AIK83153.1  1295 aa phosphoribosylformylglycinamidine synthase <1e-323 ●●●●● -4.23 -4.23435566054049
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_1194  AIK79817.1  531 aa anthranilate synthase component II <1e-323 ●●●●● -4.21 -4.20732001209123
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4686  AIK83220.1  345 aa phosphoribosylformylglycinamidine cyclo-ligase 3.9e-8 ●●●●● -4.12 -4.1199514740241
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4135  AIK82681.1  410 aa serA <1e-323 ●●●●● -4.06 -4.05861779133859
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2495  AIK81092.1  466 aa leuC <1e-323 ●●●●● -4.05 -4.05285378708489
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3142  AIK81714.1  259 aa twin arginine-targeting protein translocase TatC <1e-323 ●●●●○ -3.96 -3.96389695647803
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_1548  AIK80168.1  412 aa 3-phosphoshikimate 1-carboxyvinyltransferase 4.9e-7 ●●●●○ -3.93 -3.93173354643981
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3205  AIK81773.1  616 aa dihydroxy-acid dehydratase <1e-323 ●●●●○ -3.9 -3.90415881208498
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_5023  AIK83549.1  579 aa hypothetical protein <1e-323 ●●●●○ -3.77 -3.77414478688979
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3862  AIK82412.1  284 aa putative P-loop containing ATPase 4.8e-7 ●●●●○ -3.56 -3.5555567952866
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4883  AIK83410.1  216 aa rcsB <1e-323 ●●●●○ -3.54 -3.53534473705801
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3978  AIK82526.1  117 aa hypothetical protein 1.9e-12 ●●●●○ -3.52 -3.518389219254
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2215  AIK80820.1  431 aa phosphate regulon sensor kinase PhoR <1e-323 ●●●●○ -3.43 -3.43438178987804
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3613  AIK82168.1  397 aa flavo, HI0933 family protein 3.7e-9 ●●●●○ -3.36 -3.36106694856597
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4579  AIK83118.1  386 aa pheA <1e-323 ●●●●○ -3.31 -3.31086286403209
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2967  AIK81552.1  150 aa phosphonate C-P lyase system protein PhnG 0.00018 ●●●●○ -3.3 -3.29695487842759
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4025  AIK82572.1  490 aa tolC outer membrane channel 1.0e-6 ●●●●○ -3.28 -3.27763460471654
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3368  AIK81925.1  205 aa 2-oxo-3-deoxygalactonate 6-phosphate aldolase <1e-323 ●●●●○ -3.27 -3.27277461561967
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4503  AIK83041.1  41 aa hypothetical protein 4.2e-7 ●●●●○ -3.24 -3.23614030663516
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4578  AIK83116.1  373 aa tyrA 2.8e-11 ●●●●○ -3.19 -3.1852244890347
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_5017  AIK83543.1  722 aa tyrosine-protein kinase etk 2.1e-12 ●●●●○ -3.16 -3.16153205358015
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_1549  AIK80169.1  362 aa phosphoserine transaminase 5.2e-5 ●●●●○ -3.14 -3.1442857838189
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2084  AIK80689.1  833 aa copper-translocating P-type ATPase <1e-323 ●●●●○ -3.07 -3.07494055055066
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3086  AIK81667.1  529 aa phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase <1e-323 ●●●●○ -3.04 -3.0426210463551
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3830  AIK82380.1  38 aa hypothetical protein 4.4e-16 ●●●●○ -3.02 -3.02160703906757
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3425  AIK81982.1  448 aa putative efflux pump outer membrane protein ttgC 2.2e-7 ●●●●○ -3.01 -3.00714698255712
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3791  AIK82346.1  272 aa dehydroshikimate reductase <1e-323 ●●●○○ -2.98 -2.98352935873419
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3088  AIK81668.1  431 aa phosphoribosylamine--glycine ligase <1e-323 ●●●○○ -2.98 -2.98249609046259
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3046  AIK81631.1  165 aa chorismate lyase <1e-323 ●●●○○ -2.97 -2.97297784271425
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3143  AIK81715.1  178 aa twin arginine-targeting protein translocase TatB 2.7e-10 ●●●○○ -2.97 -2.97189006724269
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_5039  AIK83565.1  258 aa imidazole glycerol phosphate synthase, HisF subunit 3.5e-14 ●●●○○ -2.96 -2.96054213125548
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_1797  AIK80410.1  238 aa succinate dehydrogenase iron-sulfur protein 6.1e-5 ●●●○○ -2.9 -2.90377684964005
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2588  AIK81185.1  323 aa phosphoserine phosphatase SerB 1.7e-5 ●●●○○ -2.9 -2.89752393328699
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3687  AIK82242.1  191 aa iron-sulfur cluster scaffold protein 0.031 ●●●○○ -2.89 -2.89053404464674
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4840  AIK83367.1  166 aa nuoE 0.0039 ●●●○○ -2.89 -2.88769557297034
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2219  AIK80824.1  304 aa glucokinase family protein <1e-323 ●●●○○ -2.79 -2.78582075542143
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4907  AIK83433.1  114 aa yejG-like family protein 1.0e-6 ●●●○○ -2.76 -2.76040706237889
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4157  AIK82703.1  88 aa flavinator of succinate dehydrogenase family protein 5.5e-10 ●●●○○ -2.72 -2.71907240619755
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4202  AIK82747.1  211 aa bacterial regulatory, luxR family protein 1.5e-10 ●●●○○ -2.71 -2.71288497383065
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3181  AIK81749.1  448 aa wzyE family protein <1e-323 ●●●○○ -2.68 -2.67894636091956
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4981  AIK83507.1  333 aa helix-turn-helix family protein <1e-323 ●●●○○ -2.65 -2.65355982585037
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_1564  AIK80184.1  164 aa lrp transcriptional dual regulator 5.5e-10 ●●●○○ -2.61 -2.60910664048036
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4176  AIK82721.1  65 aa virulence Q domain protein 0.0077 ●●●○○ -2.61 -2.60610573815763
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_1193  AIK79816.1  520 aa anthranilate synthase component I 0.0016 ●●●○○ -2.6 -2.59844744322448
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3137  AIK81709.1  233 aa NAD(P)H-flavin reductase <1e-323 ●●●○○ -2.57 -2.57013339044356
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2128  AIK80733.1  81 aa rcnR transcriptional repressor 0.0012 ●●●○○ -2.53 -2.53062916317165
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2971  AIK81556.1  252 aa phosphonate C-P lyase system protein PhnK 3.0e-5 ●●●○○ -2.53 -2.52699494305962
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4797  AIK83324.1  182 aa hypothetical protein 0.0077 ●●●○○ -2.51 -2.50916511956339
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_1430  AIK80051.1  276 aa ferrous iron permease efeU <1e-323 ●●●○○ -2.51 -2.50760963789835
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4733  AIK83267.1  290 aa N-acetylmuramoyl-L-alanine amidase 1 <1e-323 ●●●○○ -2.5 -2.49831253105363
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_5045  AIK83571.1  299 aa ATP phosphoribosyltransferase <1e-323 ●●●○○ -2.49 -2.48737842192743
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3253  AIK81814.1  161 aa regulator of ribonuclease activity A <1e-323 ●●●○○ -2.48 -2.47522560081396
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2327  AIK80931.1  447 aa ubiquinone oxidoreductase, Na(+)-translocating, A subunit 0.0078 ●●●○○ -2.45 -2.4530911910935
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2596  AIK81193.1  264 aa putative DNase 9.7e-5 ●●●○○ -2.45 -2.44851072895891
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3204  AIK81771.1  296 aa bacterial regulatory helix-turn-helix, lysR family protein <1e-323 ●●●○○ -2.44 -2.44195267066963
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3986  AIK82534.1  83 aa hdeA/HdeB family protein 5.7e-6 ●●●○○ -2.42 -2.42326339820509
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2839  AIK81428.1  332 aa fructose-1-6-bisphosphatase family protein 3.4e-8 ●●●○○ -2.38 -2.38413204663691
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3191  AIK81759.1  367 aa undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase 6.9e-8 ●●●○○ -2.38 -2.37648763223533
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2647  AIK81241.1  44 aa hypothetical protein 0.031 ●●●○○ -2.37 -2.37121301751711
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2494  AIK81091.1  363 aa 3-isopropylmalate dehydrogenase <1e-323 ●●●○○ -2.36 -2.35588659298098
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3211  AIK81779.1  112 aa hypothetical protein <1e-323 ●●●○○ -2.35 -2.35320282763406
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_1417  AIK80038.1  237 aa putative membrane protein 8.1e-7 ●●●○○ -2.33 -2.32667248921816
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2782  AIK81371.1  43 aa hypothetical protein 7.9e-9 ●●●○○ -2.33 -2.32595297154185
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4685  AIK83219.1  213 aa phosphoribosylglycinamide formyltransferase 0.0046 ●●●○○ -2.3 -2.29642229094549
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2100  AIK80705.1  175 aa primosomal replication priB and priC family protein 5.8e-8 ●●●○○ -2.3 -2.29524350287812
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4254  AIK82799.1  392 aa acetyl-CoA C-acetyltransferase family protein 7.1e-7 ●●●○○ -2.26 -2.26435629177333
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2862  AIK81451.1  220 aa iron-sulfur cluster repair di-iron protein 2.9e-9 ●●●○○ -2.24 -2.23858986287854
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_5042  AIK83568.1  355 aa hisB <1e-323 ●●●○○ -2.24 -2.23675219941848
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3445  AIK82002.1  335 aa zinc-binding alcohol dehydrogenase family protein 9.3e-9 ●●●○○ -2.24 -2.23650073940503
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2620  AIK81214.1  157 aa hypothetical protein 2.2e-5 ●●●○○ -2.24 -2.23516484668183
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3539  AIK82095.1  331 aa D-xylose ABC transporter, D-xylose-binding protein <1e-323 ●●●○○ -2.22 -2.22274847162684
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2077  AIK80682.1  256 aa short chain dehydrogenase family protein 9.1e-5 ●●●○○ -2.22 -2.22147455174209
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3728  AIK82283.1  187 aa glutamine amidotransferase of anthranilate synthase/aminodeoxychorismate synthase family protein <1e-323 ●●●○○ -2.18 -2.18388832239607
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3970  AIK82518.1  549 aa dihydroxyacetone kinase 0.00061 ●●●○○ -2.18 -2.17617761438516
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_1161  AIK79784.1  269 aa sapF 4.0e-5 ●●●○○ -2.15 -2.1500811927699
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2045  AIK80651.1  343 aa oxidoreductase, NAD-binding Rossmann fold family protein 1.6e-11 ●●●○○ -2.14 -2.13737861514228
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_5102  AIK83628.1  1195 aa lipid A export permease/ATP-binding protein MsbA <1e-323 ●●●○○ -2.13 -2.13240686367546
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2728  AIK81318.1  740 aa glycosyl transferases group 1 family protein <1e-323 ●●●○○ -2.12 -2.12191567445051
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4100  AIK82646.1  243 aa ribosomal RNA small subunit methyltransferase E 4.2e-10 ●●●○○ -2.12 -2.11777877219051
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3585  AIK82140.1  171 aa yhjQ family protein <1e-323 ●●●○○ -2.11 -2.11162042111305
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4273  AIK82817.1  420 aa diaminopimelate decarboxylase 3.8e-15 ●●●○○ -2.1 -2.10214927118889
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2833  AIK81422.1  128 aa cytochrome b 5.5e-7 ●●●○○ -2.1 -2.10148834443889
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4081  AIK82627.1  91 aa that protects iron-sulfur proteins against oxidative damage <1e-323 ●●●○○ -2.07 -2.06670003563388
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_1081  AIK79704.1  301 aa bacterial regulatory helix-turn-helix, lysR family protein 0.046 ●●●○○ -2.07 -2.06661356375638
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4742  AIK83277.1  131 aa hypothetical protein 0.00098 ●●●○○ -2.03 -2.03411519288998
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2199  AIK80804.1  38 aa hypothetical protein 1.0e-6 ●●●○○ -2.03 -2.03407038341484
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4923  AIK83449.1  312 aa 1-phosphofructokinase <1e-323 ●●●○○ -2.03 -2.03271879652973
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4011  AIK82558.1  273 aa undecaprenyl-diphosphatase UppP <1e-323 ●●●○○ -2 -2.0027178246777
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