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Sorted by significance (p<0.05) and Fitness z-Scores (highest impact first):

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Pathogen Locus Protein UniProt Gene Length Product p-Value Fitness z-Score  Precise fitness z-Score
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A0132  NP_232533.1  Q9KN33  334 aa ribose operon repressor 5.4e-13 ●●●●● -4.48 -4.48441896150347
Haemophilus influenzae Rd KW20  HI_0942  NP_439102.1  P44945  recC  1121 aa exodeoxyribonuclease V subunit gamma 1.5e-5 ●●●●● -4.48 -4.48089345872733
Escherichia coli M12  CO715_24835  ATI08647.1  321 aa bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA 4.9e-7 ●●●●● -4.48 -4.47703566252335
Serratia marcescens Strain UMH9  BVG96_19040  ASL99591.1  239 aa DNA-binding response regulator 2.2e-7 ●●●●● -4.47 -4.46911287762607
Salmonella enterica Serovar Typhimurium SL1344  SL1344_2472  CBW18574.1  A0A0H3NE99  guaB  488 aa inosine-5'-monophosphate dehydrogenase 1.3e-14 ●●●●● -4.47 -4.46796744505262
Salmonella enterica Serovar Typhimurium SL1344  SL1344_3566  CBW19660.1  A0A0H3NH66  325 aa hypothetical phosphosugar-binding protein 0.038 ●●●●● -4.46 -4.45767587271965
Acinetobacter baumannii ATCC 17978  A1S_1801  ABO12228.1  53 aa Putative RND family drug transporter 2.3e-51 ●●●●● -4.45 -4.45463397818731
Vibrio parahaemolyticus RIMD 2210633  VP_0212  BAC58475.1  Q87T58  352 aa ADP-heptose-LPS heptosyltransferase II 1.8e-5 ●●●●● -4.45 -4.44920679515809
Salmonella enterica Serovar Typhimurium ST4 74  STM474_0708  WP_001258803.1  E8XA39  ybfM  468 aa chitoporin 3.5e-28 ●●●●● -4.44 -4.44457963737552
Serratia marcescens Strain UMH9  BVG96_00190  ASL96125.1  272 aa 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase 2.0e-6 ●●●●● -4.44 -4.44343951306453
Acinetobacter baumannii ATCC 17978  A1S_2964  ABO13367.1  155 aa phosphoribosylaminoimidazole carboxylase mutase subunit 1.9e-28 ●●●●● -4.44 -4.4431264688526
Serratia marcescens Strain UMH9  BVG96_22150  ASM00147.1  325 aa elongation factor P lysine(34) lysyltransferase 2.0e-7 ●●●●● -4.44 -4.43767763139424
Haemophilus influenzae Rd KW20  HI_0551  NP_438709.1  P44751  apaH  275 aa diadenosine tetraphosphatase 1.9e-5 ●●●●● -4.42 -4.4237157393738
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0833  NP_230481.1  P29491  tcpD  278 aa toxin co-regulated pilus biosynthesis protein D 2.3e-7 ●●●●● -4.42 -4.42353030637122
Haemophilus influenzae Rd KW20  HI_0740  NP_438900.2  Q57290  550 aa phosphomannomutase 2.0e-5 ●●●●● -4.41 -4.41490157061962
Serratia marcescens Strain UMH9  BVG96_14165  ASL98700.1  306 aa coproporphyrinogen III oxidase 6.0e-6 ●●●●● -4.41 -4.41108570287215
Salmonella enterica Serovar Typhimurium ST4 74  STM474_0955  WP_001134268.1  E8XCS5  ycaM  473 aa amino acid permease 1.7e-31 ●●●●● -4.41 -4.40885282538034
Salmonella enterica Serovar Typhimurium SL1344  SL1344_0894  CBW16990.1  A0A0H3NJK9  cydC  573 aa transport ATP-binding protein CydC 4.4e-15 ●●●●● -4.4 -4.40413429844497
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3419  WP_001083896.1  E8XC79  257 aa DeoR/GlpR transcriptional regulator 1.7e-10 ●●●●● -4.4 -4.40315899748466
Serratia marcescens Strain UMH9  BVG96_22550  ASM00218.1  705 aa polyribonucleotide nucleotidyltransferase 6.5e-7 ●●●●● -4.4 -4.40004772030192
Salmonella enterica Serovar Typhimurium SL1344  SL1344_3665  CBW19758.1  A0A0H3NMX5  cysE  273 aa serine acetyltransferase 8.5e-16 ●●●●● -4.4 -4.39905127633741
Acinetobacter baumannii ATCC 17978  A1S_2131  ABO12558.1  280 aa hypothetical protein 1.9e-33 ●●●●● -4.39 -4.38979291957782
Salmonella enterica Serovar Typhimurium ST4 74  STM474_0827  WP_000168180.1  E8XBR5  moaA  329 aa GTP 3',8-cyclase MoaA 2.9e-9 ●●●●● -4.39 -4.38709269047028
Salmonella enterica Serovar Typhimurium SL1344  SL1344_0915  CBW17011.1  A0A0H3NBJ7  aroA  427 aa 3-phosphoshikimate 1-carboxyvinyltransferase 5.8e-14 ●●●●● -4.39 -4.38684452041793
Salmonella enterica Serovar Typhimurium SL1344  SL1344_2527  CBW18628.1  A0A0H3NPU7  purG  1295 aa Phosphoribosylformylglycinamidine synthase 2.6e-17 ●●●●● -4.39 -4.38640347903816
Streptococcus pyogenes M1 5448  SP5448_03570  WP_011285626.1  309 aa DNA recombination protein RecT 6.2e-7 ●●●●● -4.38 -4.38387098949451
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4811  AIK83338.1  505 aa amidophosphoribosyltransferase <1e-323 ●●●●● -4.38 -4.38303093695164
Salmonella enterica Serovar Typhimurium ST4 74  STM474_4244  WP_000591793.1  E8XKC9  pfkA  320 aa ATP-dependent 6-phosphofructokinase 3.1e-9 ●●●●● -4.38 -4.38074339132169
Escherichia coli M12  CO715_20855  ATI07958.1  138 aa flagellar biosynthesis protein FlgB 6.5e-11 ●●●●● -4.36 -4.36165441664373
Serratia marcescens Strain UMH9  BVG96_00185  ASL96124.1  125 aa Co2+/Mg2+ efflux protein ApaG 1.4e-7 ●●●●● -4.36 -4.35747727864212
Vibrio parahaemolyticus RIMD 2210633  VPA_1174  BAC62517.1  Q87GZ1  35 aa hypothetical protein 3.8e-5 ●●●●● -4.35 -4.35395986178412
Salmonella enterica Serovar Typhimurium SL1344  SL1344_1728  CBW17823.1  A0A0H3NC36  ldcA  304 aa conserved hypothetical protein 0.047 ●●●●● -4.35 -4.35303105664395
Acinetobacter baumannii ATCC 17978  A1S_3340  ABO13729.1  A3M9Y5  pyrE  216 aa orotate phosphoribosyltransferase 1.8e-32 ●●●●● -4.34 -4.34197948298693
Salmonella enterica Serovar Typhimurium SL1344  SL1344_2876  CBW18974.1  A0A0H3NFA2  invE  372 aa cell invasion protein 0.044 ●●●●● -4.34 -4.33799322097929
Salmonella enterica Serovar Typhimurium ST4 74  STM474_2902  WP_000073810.1  E8XJC7  660 aa DNA helicase 3.1e-30 ●●●●● -4.34 -4.33732116915979
Acinetobacter baumannii ATCC 17978  A1S_0906  ABO11338.1  337 aa delta-aminolevulinic acid dehydratase 2.7e-47 ●●●●● -4.33 -4.32796077101816
Mycobacterium avium subsp. paratuberculosis K10  MAP_1762c  AAS04079.1  Q73Z41  536 aa hypothetical protein 1.1e-5 ●●●●● -4.32 -4.32286365652958
Acinetobacter baumannii ATCC 17978  A1S_0060  ABO10555.2  275 aa hypothetical protein 6.1e-51 ●●●●● -4.32 -4.32221030739413
Salmonella enterica Serovar Typhimurium SL1344  SL1344_2937  CBW19036.1  A0A0H3NFH5  relA  744 aa GTP pyrophosphokinase 0.039 ●●●●● -4.32 -4.32136739236023
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3765  WP_000160774.1  E8XFB0  gor  450 aa glutathione-disulfide reductase 5.4e-9 ●●●●● -4.32 -4.32104000346873
Mycobacterium avium subsp. paratuberculosis K10  MAP_0271  AAS02588.1  Q745R7  proX  338 aa ProX 1.2e-5 ●●●●● -4.32 -4.31983704115968
Vibrio parahaemolyticus RIMD 2210633  VPA_1355  BAC62698.1  Q87GG1  627 aa putative type III secretion system EscV protein 4.4e-5 ●●●●● -4.32 -4.31539763772258
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A0925  NP_233310.1  Q9KL24  pyrC  350 aa dihydroorotase 6.3e-12 ●●●●● -4.31 -4.31137140134885
Salmonella enterica Serovar Typhimurium ST4 74  STM474_0753  WP_000785811.1  E8XAW3  gltA  427 aa citrate synthase 2.2e-22 ●●●●● -4.3 -4.30073283688998
Salmonella enterica Serovar Typhimurium SL1344  SL1344_4028  CBW20117.1  A0A0H3NV05  yneC  97 aa conserved hypothetical protein 0.044 ●●●●● -4.29 -4.29131222882939
Salmonella enterica Serovar Typhimurium SL1344  SL1344_4336  CBW20422.1  A0A0H3NIW5  cpdB  647 aa 2',3'-cyclic-nucleotide 2'-phosphodiesterase 0.044 ●●●●● -4.29 -4.28732422389998
Vibrio parahaemolyticus RIMD 2210633  VP_1263  BAC59526.1  Q87Q87  purC  367 aa putative phosphoribosylaminoimidazole-succinocarboxamide synthase 3.6e-5 ●●●●● -4.29 -4.28670117549372
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A0075  NP_232476.1  Q9KN90  155 aa hypothetical protein 1.7e-13 ●●●●● -4.28 -4.27791688789458
Acinetobacter baumannii ATCC 17978  A1S_0130  ABO10615.2  522 aa GMP synthetase 6.1e-102 ●●●●● -4.26 -4.26453996910435
Salmonella enterica Serovar Typhimurium SL1344  SL1344_0680  CBW16779.1  A0A0H3NJ17  pgm  546 aa phosphoglucomutase 1.2e-15 ●●●●● -4.26 -4.25672557673708
Salmonella enterica Serovar Typhimurium SL1344  SL1344_3680  CBW19774.1  A0A0H3NMY1  rfaK  287 aa lipopolysaccharide 1,2-N-acetylglucosaminetransferase 0.04 ●●●●● -4.24 -4.23922991635783
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4619  AIK83153.1  1295 aa phosphoribosylformylglycinamidine synthase <1e-323 ●●●●● -4.23 -4.23435566054049
Acinetobacter baumannii ATCC 17978  A1S_2903  ABO13309.2  296 aa hypothetical protein 5.4e-19 ●●●●● -4.23 -4.23394146606472
Salmonella enterica Serovar Typhimurium ST4 74  STM474_4362  WP_001187509.1  E8XLC2  purH  529 aa bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 5.2e-10 ●●●●● -4.23 -4.23376312681421
Mycobacterium avium subsp. paratuberculosis K10  MAP_3609  AAS06159.1  Q73TV9  516 aa hypothetical protein 1.7e-5 ●●●●● -4.23 -4.2337405963849
Serratia marcescens Strain UMH9  BVG96_20305  ASL99821.1  933 aa DNA polymerase I 1.2e-6 ●●●●● -4.23 -4.23078580377524
Salmonella enterica Serovar Typhimurium SL1344  SL1344_0042  CBW16143.1  A0A0H3NCJ0  679 aa hypothetical glycosyl hydrolase 1.8e-16 ●●●●● -4.23 -4.22710702241334
Acinetobacter baumannii ATCC 17978  A1S_1637  ABO12064.1  90 aa DNA-binding protein HU-beta 1.1e-46 ●●●●● -4.22 -4.2177919676681
Salmonella enterica Serovar Typhimurium SL1344  SL1344_3840  CBW19931.1  A0A0H3NHR5  gidB  209 aa glucose inhibited division protein 0.041 ●●●●● -4.22 -4.2162392267061
Vibrio parahaemolyticus RIMD 2210633  VP_2351  BAC60614.1  Q87MA6  nqrA  446 aa sodium-translocating NADH-quinone reductase, subunit A 4.8e-5 ●●●●● -4.22 -4.21592770187616
Serratia marcescens Strain UMH9  BVG96_21195  ASL99978.1  360 aa undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase 1.1e-9 ●●●●● -4.21 -4.21299393670146
Haemophilus influenzae Rd KW20  HI_0465  NP_438626.1  P43885  serA  410 aa D-3-phosphoglycerate dehydrogenase 4.8e-5 ●●●●● -4.21 -4.20905917211928
Salmonella enterica Serovar Typhimurium SL1344  SL1344_3368  CBW19463.1  A0A0H3NGM8  aroE  272 aa shikimate dehydrogenase 8.9e-19 ●●●●● -4.21 -4.20763425090662
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_1194  AIK79817.1  531 aa anthranilate synthase component II <1e-323 ●●●●● -4.21 -4.20732001209123
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3887  WP_000591818.1  E8XGR3  rfaK  381 aa LPS 1,2-N-acetylglucosaminetransferase 7.8e-10 ●●●●● -4.21 -4.20708507992495
Vibrio parahaemolyticus RIMD 2210633  VP_2288  BAC60551.1  Q87MG7  gmhA  191 aa phosphoheptose isomerase 5.0e-5 ●●●●● -4.21 -4.20667116687781
Salmonella enterica Serovar Typhimurium ST4 74  STM474_2168  WP_001103643.1  E8XC37  rfbK  477 aa phosphomannomutase CpsG 2.4e-26 ●●●●● -4.2 -4.20491180337832
Acinetobacter baumannii ATCC 17978  A1S_3102  ABO13499.2  258 aa toluene tolerance efflux transporter 5.0e-36 ●●●●● -4.2 -4.19905147960178
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3514  WP_000162405.1  E8XD57  205 aa L(+)-tartrate dehydratase subunit beta 3.1e-25 ●●●●● -4.2 -4.19853684333136
Mycobacterium avium subsp. paratuberculosis K10  MAP_0768c  AAS03085.1  Q742R7  298 aa hypothetical protein 2.1e-5 ●●●●● -4.18 -4.18421286639172
Salmonella enterica Serovar Typhimurium SL1344  SL1344_4114  CBW20202.1  A0A0H3NIN5  purD  429 aa phosphoribosylglycineamide synthetase 2.1e-17 ●●●●● -4.18 -4.18355423458075
Vibrio parahaemolyticus RIMD 2210633  VPA_1349  BAC62692.1  Q87GG7  71 aa putative Type III secretion protein Spa33 7.8e-5 ●●●●● -4.18 -4.18168084823626
Salmonella enterica Serovar Typhimurium ST4 74  STM474_1181  WP_000827470.1  E8XEV4  rne  1067 aa ribonuclease E 1.9e-10 ●●●●● -4.18 -4.18100862746341
Acinetobacter baumannii ATCC 17978  A1S_0417  ABO10872.2  A3M1S8  leuC  472 aa 3-isopropylmalate dehydratase (isomerase) subunit with LeuD 1.1e-73 ●●●●● -4.18 -4.17654437581093
Mycobacterium avium subsp. paratuberculosis K10  MAP_4287c  AAS06837.1  Q73RZ1  151 aa hypothetical protein 2.2e-5 ●●●●● -4.17 -4.17253734244036
Serratia marcescens Strain UMH9  BVG96_04515  ASL96909.1  715 aa tyrosine-protein kinase 1.6e-6 ●●●●● -4.17 -4.17183269713977
Vibrio parahaemolyticus RIMD 2210633  VP_1601  BAC59863.1  Q87PB7  pyrD  336 aa dihydroorotate dehydrogenase 5.8e-5 ●●●●● -4.17 -4.17110303788634
Salmonella enterica Serovar Typhimurium ST4 74  STM474_2652  WP_000985204.1  E8XGN9  asrA  347 aa anaerobic sulfite reductase subunit A 1.1e-54 ●●●●● -4.17 -4.16662821701278
Streptococcus pyogenes M1 5448  SP5448_04065  WP_010922410.1  398 aa methionine adenosyltransferase 6.6e-6 ●●●●● -4.16 -4.16276359493961
Acinetobacter baumannii ATCC 17978  A1S_3235  ABO13625.2  205 aa imidazole glycerol phosphate synthetase glutamine amidotransferase subunit 1.1e-45 ●●●●● -4.16 -4.16205010954198
Haemophilus influenzae Rd KW20  HI_1321  NP_439472.1  P45157  recB  1211 aa exodeoxyribonuclease V subunit beta 5.9e-5 ●●●●● -4.16 -4.15984731729038
Vibrio parahaemolyticus RIMD 2210633  VP_0130  BAC58393.1  Q87TE0  hslO  291 aa conserved hypothetical protein 6.6e-5 ●●●●● -4.14 -4.14054644808444
Vibrio parahaemolyticus RIMD 2210633  VPA_1351  BAC62694.1  Q87GG5  336 aa hypothetical protein 9.3e-5 ●●●●● -4.14 -4.13973791487986
Streptococcus pyogenes M1 5448  SP5448_02330  WP_002988747.1  138 aa DUF722 domain-containing protein 1.4e-8 ●●●●● -4.14 -4.13680750949186
Salmonella enterica Serovar Typhimurium SL1344  SL1344_3839  CBW19930.1  A0A0H3NNA7  atpI  126 aa ATP synthase protein I. 4.3e-20 ●●●●● -4.14 -4.13602484165669
Salmonella enterica Serovar Typhimurium ST4 74  STM474_2947  WP_000985529.1  E8XK53  proV  400 aa proline/glycine betaine ABC transporter ATP-binding protein ProV 9.5e-58 ●●●●● -4.14 -4.13567888598682
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3282  WP_000540889.1  E8XAI2  307 aa polysaccharide deacetylase 1.7e-26 ●●●●● -4.13 -4.13015269392217
Vibrio parahaemolyticus RIMD 2210633  VP_1054  BAC59317.1  Q87QU5  378 aa cytochrome d ubiquinol oxidase, subunit II 7.2e-5 ●●●●● -4.12 -4.12049847368353
Vibrio parahaemolyticus RIMD 2210633  VPA_1333  BAC62676.1  Q87GI3  161 aa hypothetical protein 0.0001 ●●●●● -4.12 -4.12049153908776
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4686  AIK83220.1  345 aa phosphoribosylformylglycinamidine cyclo-ligase 3.9e-8 ●●●●● -4.12 -4.1199514740241
Salmonella enterica Serovar Typhimurium SL1344  SL1344_3020  CBW19119.1  A0A0H3NHK4  xerD  298 aa Tyrosine recombinase xerD. 7.9e-17 ●●●●● -4.12 -4.11659717847628
Vibrio parahaemolyticus RIMD 2210633  VP_2518  BAC60781.1  Q87LU3  627 aa pyruvate dehydrogenase, E2 component, dihydrolipoamide acetyltransferase 7.3e-5 ●●●●● -4.12 -4.11507333721645
Salmonella enterica Serovar Typhimurium SL1344  SL1344_3689  CBW19783.1  A0A0H3NHE6  rfaQ  344 aa lipopolysaccharide core biosynthesis protein 0.038 ●●●●● -4.11 -4.11079721415578
Mycobacterium avium subsp. paratuberculosis K10  MAP_0833c  AAS03150.1  Q742K2  451 aa hypothetical protein 3.1e-5 ●●●●● -4.09 -4.08934406634275
Salmonella enterica Serovar Typhimurium ST4 74  STM474_4093  WP_001280776.1  E8XIM6  trxA  109 aa thioredoxin TrxA 4.4e-10 ●●●●● -4.08 -4.08444439018895
Salmonella enterica Serovar Typhimurium ST4 74  STM474_0956  WP_000067973.1  E8XCS6  pflA  265 aa pyruvate formate lyase 1-activating protein 2.1e-9 ●●●●● -4.08 -4.08444439018895
Salmonella enterica Serovar Typhimurium ST4 74  STM474_1146  WP_001044610.1  E8XER9  mdoH  847 aa glucans biosynthesis glucosyltransferase MdoH 1.8e-9 ●●●●● -4.08 -4.08141750876269
Salmonella enterica Serovar Typhimurium ST4 74  STM474_0319  WP_000970302.1  E8XIX2  sinR  315 aa LysR family transcriptional regulator 2.4e-26 ●●●●● -4.08 -4.07624692524393
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A0040  NP_232441.1  Q9KNC5  308 aa hypothetical protein 1.0e-12 ●●●●● -4.07 -4.07465866199706
Salmonella enterica Serovar Typhimurium ST4 74  STM474_0124  WP_000762406.1  E8XH29  fruR  334 aa catabolite repressor/activator 7.1e-30 ●●●●● -4.07 -4.07097252967353
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