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Sorted by significance (p<0.05) and Fitness z-Scores (highest impact first):

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Pathogen Locus Protein UniProt Gene Length Product p-Value Fitness z-Score  Precise fitness z-Score
Mycobacterium avium subsp. paratuberculosis K10  MAP_3745  AAS06295.1  Q73TH3  250 aa hypothetical protein 0.0046 ●●●○○ -2.59 -2.58991343885824
Acinetobacter baumannii ATCC 17978  A1S_1034  ABO11466.2  194 aa putative ligase 1.0e-27 ●●●○○ -2.59 -2.58829515536054
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3018  WP_001147852.1  E8XL07  sicP  130 aa chaperone SicP 1.8e-6 ●●●○○ -2.59 -2.58683301557164
Salmonella enterica Serovar Typhimurium ST4 74  STM474_2534  WP_000487600.1  E8XFP0  ptsH  85 aa phosphocarrier protein Hpr 2.5e-10 ●●●○○ -2.58 -2.58407565537043
Streptococcus pyogenes M1 5448  SP5448_02695  WP_010922558.1  273 aa glutamate 5-kinase 0.0099 ●●●○○ -2.58 -2.58328772861914
Streptococcus pyogenes M1 5448  SP5448_06850  WP_002985428.1  303 aa DNA-binding protein WhiA 0.022 ●●●○○ -2.58 -2.58328772861914
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3886  WP_000958458.1  E8XGR2  rfaL  404 aa O-antigen ligase RfaL 1.9e-20 ●●●○○ -2.58 -2.57908387658443
Streptococcus pyogenes M1 5448  SP5448_06250  WP_010922157.1  303 aa 1-phosphofructokinase 0.0019 ●●●○○ -2.58 -2.57848104612882
Streptococcus pyogenes M1 5448  SP5448_06510  WP_010922134.1  581 aa alpha-L-Rha alpha-1,3-L-rhamnosyltransferase 0.015 ●●●○○ -2.58 -2.57848104612882
Haemophilus influenzae Rd KW20  HI_1633  NP_439775.1  P45283  purA  432 aa adenylosuccinate synthetase 0.012 ●●●○○ -2.58 -2.57825578715662
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A0836  NP_233222.1  Q9KLB0  192 aa hexapeptide repeat-containing acetyltransferase 3.3e-13 ●●●○○ -2.58 -2.57761509132882
Salmonella enterica Serovar Typhimurium ST4 74  STM474_2524  WP_001119759.1  E8XFN0  xapA  277 aa xanthosine phosphorylase 3.2e-20 ●●●○○ -2.58 -2.57615237094214
Salmonella enterica Serovar Typhimurium ST4 74  STM474_2418  WP_000172747.1  E8XEG4  nuoI  180 aa NADH-quinone oxidoreductase subunit NuoI 1.5e-16 ●●●○○ -2.58 -2.57602450786776
Haemophilus influenzae Rd KW20  HI_0479  NP_438639.1  P43715  atpD  457 aa F0F1 ATP synthase subunit beta 0.012 ●●●○○ -2.57 -2.57422269570837
Mycobacterium avium subsp. paratuberculosis K10  MAP_1852  AAS04169.1  Q73YV3  351 aa hypothetical protein 0.0048 ●●●○○ -2.57 -2.57409937381866
Acinetobacter baumannii ATCC 17978  A1S_2115  ABO12542.1  160 aa methyl-directed mismatch repair enzyme 1.8e-6 ●●●○○ -2.57 -2.57200293672067
Streptococcus pyogenes M1 5448  SP5448_06800  WP_002985298.1  115 aa 50S ribosomal protein L19 0.019 ●●●○○ -2.57 -2.57175169064237
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3137  AIK81709.1  233 aa NAD(P)H-flavin reductase <1e-323 ●●●○○ -2.57 -2.57013339044356
Salmonella enterica Serovar Typhimurium ST4 74  STM474_0564  WP_000681030.1  E8X918  fimA  185 aa type 1 fimbrial protein subunit FimA 6.1e-20 ●●●○○ -2.57 -2.5683268776306
Salmonella enterica Serovar Typhimurium ST4 74  STM474_2008  WP_000502811.1  E8XAB9  fliM  334 aa flagellar motor switch protein FliM 1.7e-5 ●●●○○ -2.56 -2.56326656332274
Salmonella enterica Serovar Typhimurium SL1344  SL1344_1625  CBW17720.1  A0A0H3NLP1  sapD  330 aa peptide transport system ATP-binding protein SapD 1.7e-7 ●●●○○ -2.56 -2.56296492723401
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3768  WP_000028429.1  E8XFB3  281 aa fructoselysine 6-kinase 6.3e-20 ●●●○○ -2.56 -2.56267850483326
Vibrio cholerae O1 biovar El Tor str. N16961  VC_1149  NP_230794.1  Q9KSV7  548 aa glutamate decarboxylase 3.3e-10 ●●●○○ -2.56 -2.56233902476619
Streptococcus pyogenes M1 5448  SP5448_03410  WP_002992349.1  446 aa exodeoxyribonuclease VII large subunit 0.021 ●●●○○ -2.56 -2.56213832566172
Salmonella enterica Serovar Typhimurium ST4 74  STM474_2498  WP_000955748.1  E8XF53  pgtP  463 aa phosphoglycerate transporter PgtP 3.0e-20 ●●●○○ -2.56 -2.56171115444998
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3908  WP_001599866.1  E8XGT4  59 aa hypothetical protein 3.8e-20 ●●●○○ -2.56 -2.56153251330135
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3907  WP_001247078.1  E8XGT3  rph  238 aa ribonuclease PH 3.8e-20 ●●●○○ -2.56 -2.56153251330135
Vibrio parahaemolyticus RIMD 2210633  VP_0315  BAC58578.1  Q87SV7  ubiX  212 aa 3-octaprenyl-4-hydroxybenzoate carboxy-lyase 0.013 ●●●○○ -2.56 -2.56143393821612
Salmonella enterica Serovar Typhimurium ST4 74  STM474_0418  WP_000149625.1  E8XKI5  brnQ  439 aa branched-chain amino acid transporter carrier protein BrnQ 3.9e-18 ●●●○○ -2.56 -2.56138144724518
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A0020  NP_232421.1  Q9KNE5  1085 aa hypothetical protein 8.2e-13 ●●●○○ -2.56 -2.55966358120749
Salmonella enterica Serovar Typhimurium ST4 74  STM474_4258  WP_000981826.1  E8XKE3  ydeZ  333 aa autoinducer 2 ABC transporter permease LsrD 8.6e-8 ●●●○○ -2.56 -2.55956063946763
Haemophilus influenzae Rd KW20  HI_0206  NP_438375.1  P44569  603 aa NAD nucleotidase 0.013 ●●●○○ -2.56 -2.55873439722402
Vibrio parahaemolyticus RIMD 2210633  VP_0223  BAC58486.1  Q87T47  291 aa D-glucose-1-phosphate thymidylyltransferase 0.013 ●●●○○ -2.56 -2.55872137658444
Streptococcus pyogenes M1 5448  SP5448_08685  WP_010922709.1  825 aa pneumococcal-type histidine triad protein 0.0079 ●●●○○ -2.56 -2.55829297966946
Streptococcus pyogenes M1 5448  SP5448_01300  WP_010921884.1  873 aa SEC10/PgrA surface exclusion domain-containing protein 0.023 ●●●○○ -2.56 -2.55540897017526
Streptococcus pyogenes M1 5448  SP5448_01470  WP_002988132.1  249 aa tRNA pseudouridine(38-40) synthase TruA 0.03 ●●●○○ -2.56 -2.55540897017526
Vibrio parahaemolyticus RIMD 2210633  VPA_1468  BAC62811.1  Q87G49  448 aa ATP-dependent RNA helicase, DEAD box family 0.019 ●●●○○ -2.55 -2.55165903012955
Vibrio cholerae O1 biovar El Tor str. N16961  VC_2052  NP_231684.1  Q9KQE8  651 aa cytochrome c-type biogenesis protein CcmF 2.1e-9 ●●●○○ -2.55 -2.54791185918512
Salmonella enterica Serovar Typhimurium SL1344  SL1344_1685  CBW17780.1  A0A0H3NLW4  ychK  301 aa conserved hypothetical protein 2.8e-7 ●●●○○ -2.55 -2.54650560937392
Streptococcus pyogenes M1 5448  SP5448_06740  WP_002985285.1  53 aa TOMM family cytolysin streptolysin S 0.023 ●●●○○ -2.54 -2.54483426869655
Mycobacterium avium subsp. paratuberculosis K10  MAP_0588  AAS02905.1  Q743J7  632 aa hypothetical protein 0.0051 ●●●○○ -2.54 -2.54446080393294
Mycobacterium avium subsp. paratuberculosis K10  MAP_1725c  AAS04042.1  Q73Z78  342 aa hypothetical protein 0.0051 ●●●○○ -2.54 -2.54423947645738
Mycobacterium avium subsp. paratuberculosis K10  MAP_2785c  AAS05102.1  Q73W75  161 aa hypothetical protein 0.0052 ●●●○○ -2.54 -2.54234860082496
Acinetobacter baumannii ATCC 17978  A1S_0736  ABO11176.1  328 aa hypothetical protein 4.1e-24 ●●●○○ -2.54 -2.54146481632089
Salmonella enterica Serovar Typhimurium ST4 74  STM474_4185  WP_001271699.1  E8XJI9  469 aa glutamate--ammonia ligase 7.7e-6 ●●●○○ -2.54 -2.54143519141563
Serratia marcescens Strain UMH9  BVG96_00535  ASL96188.1  908 aa two-component sensor histidine kinase BarA 0.0086 ●●●○○ -2.54 -2.53974493785758
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0247  NP_229904.1  Q9KVA2  271 aa lipopolysaccharide/O-antigen transport protein 1.7e-9 ●●●○○ -2.54 -2.53800105146654
Campylobacter jejuni subsp. jejuni 81-176  CJJ81176_0275  WP_002922676.1  A0A0H3PJ65  285 aa HDOD domain-containing protein 0.0083 ●●●○○ -2.54 -2.53725386067
Vibrio parahaemolyticus RIMD 2210633  VP_1104  BAC59367.1  Q87QP5  164 aa leucine-responsive regulatory protein 0.014 ●●●○○ -2.54 -2.53671069973207
Salmonella enterica Serovar Typhimurium ST4 74  STM474_0321  WP_000787603.1  E8XIX4  239 aa adhesin/invasin protein PagN 1.2e-21 ●●●○○ -2.53 -2.53435819108734
Salmonella enterica Serovar Typhimurium ST4 74  STM474_4079  WP_001012570.1  E8XIL2  ilvG  548 aa acetolactate synthase 2 catalytic subunit 1.1e-6 ●●●○○ -2.53 -2.5336349118725
Acinetobacter baumannii ATCC 17978  A1S_3161  ABO13558.1  A3M9G4  rplS  122 aa 50S ribosomal protein L19 0.00016 ●●●○○ -2.53 -2.53299970887631
Salmonella enterica Serovar Typhimurium ST4 74  STM474_1299  WP_001259876.1  E8XGA1  sppA  618 aa signal peptide peptidase SppA 5.8e-20 ●●●○○ -2.53 -2.53283822388644
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3230  WP_000379524.1  E8X9Q4  490 aa mannitol dehydrogenase family protein 1.4e-22 ●●●○○ -2.53 -2.53207381961941
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3399  WP_001094910.1  E8XC62  tdcA  312 aa transcriptional regulator TdcA 0.0062 ●●●○○ -2.53 -2.53141196754651
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2128  AIK80733.1  81 aa rcnR transcriptional repressor 0.0012 ●●●○○ -2.53 -2.53062916317165
Vibrio parahaemolyticus RIMD 2210633  VP_2118  BAC60381.1  Q87MW3  199 aa manganese superoxide dismutase Mn-SOD 0.014 ●●●○○ -2.53 -2.52831087305723
Vibrio cholerae O1 biovar El Tor str. N16961  VC_1174  NP_230819.1  Q9KST2  trpE  523 aa anthranilate synthase component I 3.4e-9 ●●●○○ -2.53 -2.52776953086415
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2971  AIK81556.1  252 aa phosphonate C-P lyase system protein PhnK 3.0e-5 ●●●○○ -2.53 -2.52699494305962
Salmonella enterica Serovar Typhimurium ST4 74  STM474_4500  WP_000682911.1  E8X9V5  dcuS  543 aa two-component system sensor histidine kinase DcuS 7.1e-19 ●●●○○ -2.52 -2.51902139869967
Salmonella enterica Serovar Typhimurium ST4 74  STM474_2812  WP_001237670.1  E8XIG6  3824 aa biofilm-associated protein BapA 1.5e-19 ●●●○○ -2.52 -2.51851693845558
Streptococcus pyogenes M1 5448  SP5448_07560  WP_002994504.1  81 aa bacteriocin 0.0069 ●●●○○ -2.52 -2.51791684675074
Streptococcus pyogenes M1 5448  SP5448_02530  WP_010922577.1  67 aa heavy-metal-associated domain-containing protein 0.023 ●●●○○ -2.52 -2.51599417375461
Streptococcus pyogenes M1 5448  SP5448_02530  WP_011285670.1  56 aa hypothetical protein 0.023 ●●●○○ -2.52 -2.51599417375461
Streptococcus pyogenes M1 5448  SP5448_01555  WP_010922649.1  284 aa 5'-nucleotidase, lipoprotein e(P4) family 0.011 ●●●○○ -2.52 -2.51503283725654
Vibrio parahaemolyticus RIMD 2210633  VP_2346  BAC60609.1  Q9LCJ0  nqrF  407 aa sodium-translocating NADH-quinone reductase, subunit F 0.015 ●●●○○ -2.51 -2.5134130125815
Streptococcus pyogenes M1 5448  SP5448_07515  WP_002994132.1  148 aa hypothetical protein 0.023 ●●●○○ -2.51 -2.51118749126428
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0832  NP_230480.1  P0C6D5  tcpR  151 aa toxin co-regulated pilus biosynthesis protein R 7.5e-11 ●●●○○ -2.51 -2.5095576358656
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4797  AIK83324.1  182 aa hypothetical protein 0.0077 ●●●○○ -2.51 -2.50916511956339
Mycobacterium avium subsp. paratuberculosis K10  MAP_2294c  AAS04611.1  Q73XL5  1616 aa hypothetical protein 0.0056 ●●●○○ -2.51 -2.50818980811072
Haemophilus influenzae Rd KW20  HI_1290  NP_439442.1  P43902  tyrA  377 aa bifunctional chorismate mutase/prephenate dehydrogenase 0.014 ●●●○○ -2.51 -2.50779824472258
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_1430  AIK80051.1  276 aa ferrous iron permease efeU <1e-323 ●●●○○ -2.51 -2.50760963789835
Salmonella enterica Serovar Typhimurium ST4 74  STM474_4176  WP_000725364.1  E8XJI0  dsbA  207 aa thiol:disulfide interchange protein DsbA 5.8e-6 ●●●○○ -2.51 -2.50615724806214
Acinetobacter baumannii ATCC 17978  A1S_3185  ABO13580.2  1493 aa glutamate synthase large chain precursor 1.1e-23 ●●●○○ -2.51 -2.50577703311325
Vibrio parahaemolyticus RIMD 2210633  VPA_1364  BAC62707.1  Q87GF2  243 aa hypothetical protein 0.021 ●●●○○ -2.5 -2.50495441697661
Streptococcus pyogenes M1 5448  SP5448_06255  WP_002990215.1  237 aa DeoR/GlpR transcriptional regulator 0.017 ●●●○○ -2.5 -2.50445813577783
Serratia marcescens Strain UMH9  BVG96_02965  ASL96618.1  250 aa phosphoglyceromutase 0.035 ●●●○○ -2.5 -2.50430477245261
Escherichia coli O157:H7 str. EDL933  Z5110  AAG58823.1  934 aa intimin adherence protein 0.0078 ●●●○○ -2.5 -2.50288329074156
Vibrio parahaemolyticus RIMD 2210633  VPA_0956  BAC62299.1  Q87HK7  30 aa hypothetical protein 0.021 ●●●○○ -2.5 -2.50157324741922
Salmonella enterica Serovar Typhimurium ST4 74  STM474_4634  WP_000852994.1  E8XBJ0  pmba  450 aa metalloprotease PmbA 1.6e-7 ●●●○○ -2.5 -2.49970419087065
Salmonella enterica Serovar Typhimurium ST4 74  STM474_0548  WP_000589769.1  E8X8B4  allC  411 aa allantoate deiminase 1.1e-19 ●●●○○ -2.5 -2.49916675310305
Salmonella enterica Serovar Typhimurium SL1344  SL1344_1325  CBW17421.1  A0A0H3NKV1  ssrB  212 aa two-component response regulator 5.7e-5 ●●●○○ -2.5 -2.49898093217181
Escherichia coli CFT073  c2601  AAN81057.1  Q8FG04  mdtB  1040 aa Hypothetical protein yegN 0.045 ●●●○○ -2.5 -2.4988482204782
Vibrio cholerae O1 biovar El Tor str. N16961  VC_1900  NP_231534.1  Q9KQU8  fadR  279 aa fatty acid metabolism regulator 2.0e-8 ●●●○○ -2.5 -2.49835737735019
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4733  AIK83267.1  290 aa N-acetylmuramoyl-L-alanine amidase 1 <1e-323 ●●●○○ -2.5 -2.49831253105363
Campylobacter jejuni subsp. jejuni 81-176  CJJ81176_1038  WP_009882648.1  A0A0H3PCQ6  371 aa ABC transporter substrate-binding protein 0.0093 ●●●○○ -2.49 -2.49342652073
Serratia marcescens Strain UMH9  BVG96_18825  ASL99551.1  210 aa transcriptional regulator Crp 0.048 ●●●○○ -2.49 -2.49181879168468
Streptococcus pyogenes M1 5448  SP5448_00545  WP_010921789.1  61 aa hypothetical protein 0.011 ●●●○○ -2.49 -2.49099942480492
Campylobacter jejuni subsp. jejuni 81-176  CJJ81176_0689  WP_009882359.1  A1VZ21  hslU  439 aa ATP-dependent protease ATPase subunit HslU 0.0093 ●●●○○ -2.49 -2.49099889466
Salmonella enterica Serovar Typhimurium ST4 74  STM474_0217  WP_000146443.1  E8XI06  dgt  505 aa dGTPase 0.00031 ●●●○○ -2.49 -2.49087250399253
Salmonella enterica Serovar Typhimurium ST4 74  STM474_4356  WP_001044509.1  E8XLB6  hupA  90 aa DNA-binding protein HU-alpha 0.00031 ●●●○○ -2.49 -2.49087250399253
Streptococcus pyogenes M1 5448  SP5448_00670  WP_002992749.1  94 aa DUF4651 domain-containing protein 0.013 ●●●○○ -2.49 -2.48811541531073
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_5045  AIK83571.1  299 aa ATP phosphoribosyltransferase <1e-323 ●●●○○ -2.49 -2.48737842192743
Vibrio parahaemolyticus RIMD 2210633  VP_0717  BAC58980.1  Q87RR0  lipB  220 aa lipoate-protein ligase B 0.016 ●●●○○ -2.49 -2.48504944587245
Mycobacterium avium subsp. paratuberculosis K10  MAP_2314c  AAS04631.1  Q73XJ5  accD1  559 aa AccD1 0.006 ●●●○○ -2.48 -2.48387254700712
Streptococcus pyogenes M1 5448  SP5448_07635  WP_002985768.1  229 aa 50S ribosomal protein L1 0.009 ●●●○○ -2.48 -2.48234739632234
Salmonella enterica Serovar Typhimurium ST4 74  STM474_2243  WP_000703137.1  E8XCZ6  yehR  152 aa DUF1307 domain-containing protein 1.7e-19 ●●●○○ -2.48 -2.48066673217012
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0167  NP_229824.1  Q9KVH9  rep  671 aa ATP-dependent DNA helicase Rep 4.0e-10 ●●●○○ -2.48 -2.47983552377279
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3997  WP_000724476.1  E8XHQ6  466 aa c-type cytochrome 3.8e-7 ●●●○○ -2.48 -2.47772808283452
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3253  AIK81814.1  161 aa regulator of ribonuclease activity A <1e-323 ●●●○○ -2.48 -2.47522560081396
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