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Sorted by significance (p<0.05) and Fitness z-Scores (highest impact first):

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Pathogen Locus Protein UniProt Gene Length Product p-Value Fitness z-Score  Precise fitness z-Score
Streptococcus pyogenes M1 5448  SP5448_08885  WP_010922727.1  778 aa penicillin-binding protein 0.037 ●●●○○ -2.37 -2.36506434355843
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0250  NP_229907.1  Q9KVA0  374 aa iron-containing alcohol dehydrogenase 9.4e-9 ●●●○○ -2.36 -2.36330001516767
Vibrio parahaemolyticus RIMD 2210633  VP_0487  BAC58750.1  Q87SD7  783 aa sensor histidine kinase FexB 0.021 ●●●○○ -2.36 -2.36306337221256
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3270  WP_000423170.1  E8XAH0  292 aa LysR family transcriptional regulator 1.2e-17 ●●●○○ -2.36 -2.36278625411157
Acinetobacter baumannii ATCC 17978  A1S_0543  ABO10996.2  574 aa acetolactate synthase III large subunit 2.2e-40 ●●●○○ -2.36 -2.3612730426129
Salmonella enterica Serovar Typhimurium ST4 74  STM474_2878  WP_001161781.1  E8XJA3  275 aa hypothetical protein 5.0e-17 ●●●○○ -2.36 -2.36007265708133
Salmonella enterica Serovar Typhimurium ST4 74  STM474_2420  WP_000928364.1  E8XEG6  nuoG  910 aa NADH-quinone oxidoreductase subunit NuoG 4.9e-17 ●●●○○ -2.36 -2.3587397740478
Salmonella enterica Serovar Typhimurium ST4 74  STM474_2027  WP_024131109.1  E8XB17  ompS  62 aa hypothetical protein 1.6e-34 ●●●○○ -2.36 -2.35872087047259
Escherichia coli O157:H7 str. EDL933  Z3200  AAG57096.1  364 aa perosamine synthetase 0.011 ●●●○○ -2.36 -2.3561588533097
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2494  AIK81091.1  363 aa 3-isopropylmalate dehydrogenase <1e-323 ●●●○○ -2.36 -2.35588659298098
Acinetobacter baumannii ATCC 17978  A1S_0346  ABO10806.2  257 aa hypothetical protein 1.8e-34 ●●●○○ -2.36 -2.35547609518806
Salmonella enterica Serovar Typhimurium ST4 74  STM474_4491  WP_001217074.1  E8X9U6  adiY  253 aa helix-turn-helix domain-containing protein 3.4e-27 ●●●○○ -2.35 -2.35326993905546
Haemophilus influenzae Rd KW20  HI_0408  NP_438570.1  P44692  znuC  268 aa ABC transporter ATP-binding protein 0.021 ●●●○○ -2.35 -2.35325938640688
Haemophilus influenzae Rd KW20  HI_0572  NP_438729.1  P44758  PGdx  241 aa peroxiredoxin hybrid Prx5 0.021 ●●●○○ -2.35 -2.35325938640688
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3211  AIK81779.1  112 aa hypothetical protein <1e-323 ●●●○○ -2.35 -2.35320282763406
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3472  WP_000925786.1  E8XCC9  yrbE  260 aa lipid asymmetry maintenance ABC transporter permease subunit MlaE 6.0e-6 ●●●○○ -2.35 -2.35108830673495
Escherichia coli O157:H7 str. EDL933  Z3192  AAG57089.1  221 aa acetyl transferase; O-antigen biosynthesis 0.011 ●●●○○ -2.35 -2.34803017344694
Streptococcus pyogenes M1 5448  SP5448_08410  WP_002982682.1  172 aa NYN domain-containing protein 0.0047 ●●●○○ -2.35 -2.34776028659327
Streptococcus pyogenes M1 5448  SP5448_06495  WP_002985167.1  113 aa DUF2304 domain-containing protein 0.035 ●●●○○ -2.35 -2.34776028659327
Salmonella enterica Serovar Typhimurium ST4 74  STM474_1260  WP_000456065.1  E8XFI7  377 aa mechanosensitive ion channel family protein 5.0e-18 ●●●○○ -2.35 -2.34736741882612
Escherichia coli O157:H7 str. EDL933  Z4086  AAG57884.1  425 aa putative transport protein 0.011 ●●●○○ -2.35 -2.34688916899935
Salmonella enterica Serovar Typhimurium ST4 74  STM474_2670  WP_000970045.1  E8XHE3  purG  1295 aa phosphoribosylformylglycinamidine synthase 3.4e-18 ●●●○○ -2.35 -2.34582074067246
Escherichia coli CFT073  c1050  AAN79520.1  P0A6Y2  ihfB  94 aa Integration host factor beta-subunit 0.04 ●●●○○ -2.35 -2.34501254411669
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A1111  NP_233490.1  H9L4P9  200 aa thermostable hemolysin 1.0e-9 ●●●○○ -2.34 -2.34488275279278
Mycobacterium avium subsp. paratuberculosis K10  MAP_2685  AAS05002.1  Q73WH5  198 aa hypothetical protein 0.0084 ●●●○○ -2.34 -2.34480220621273
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A0936  NP_233321.1  Q9KL13  312 aa hypothetical protein 2.2e-11 ●●●○○ -2.34 -2.34441080048993
Salmonella enterica Serovar Typhimurium SL1344  SL1344_3877  CBW19967.1  A0A0H3NHU5  rfe  367 aa hypothetical undecaprenyl-phosphate alpha-N-acetylglucosaminyltransferase 8.9e-7 ●●●○○ -2.34 -2.34169886582535
Salmonella enterica Serovar Typhimurium ST4 74  STM474_1145  WP_001738192.1  E8XER8  mdoG  511 aa glucans biosynthesis protein MdoG 1.8e-5 ●●●○○ -2.34 -2.34074783402121
Salmonella enterica Serovar Typhimurium ST4 74  STM474_2423  WP_000247855.1  E8XEG9  nuoC  600 aa NADH-quinone oxidoreductase subunit C/D 8.3e-18 ●●●○○ -2.34 -2.33879846728756
Serratia marcescens Strain UMH9  BVG96_21335  ASM00003.1  720 aa DNA-dependent helicase II 0.013 ●●●○○ -2.34 -2.33778879483485
Acinetobacter baumannii ATCC 17978  A1S_0583  ABO11034.2  487 aa poly(A) polymerase I (PAP) 1.0e-13 ●●●○○ -2.34 -2.3373989564425
Escherichia coli M12  CO715_19880  ATI07777.1  129 aa methylated-DNA--[protein]-cysteine S-methyltransferase 3.1e-18 ●●●○○ -2.34 -2.33674484835853
Salmonella enterica Serovar Typhimurium ST4 74  STM474_1527  WP_001068050.1  E8XI96  ydeE  395 aa efflux MFS transporter YdeE 0.0028 ●●●○○ -2.34 -2.33580741753852
Streptococcus pyogenes M1 5448  SP5448_01610  WP_010922646.1  247 aa GntR family transcriptional regulator 0.033 ●●●○○ -2.34 -2.33526291211843
Escherichia coli M12  CO715_09145  ATI05861.1  430 aa protein TolB 1.6e-11 ●●●○○ -2.34 -2.33507568024454
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A0530  NP_232921.1  Q9KM58  1079 aa pyruvate-flavoredoxin oxidoreductase 1.5e-8 ●●●○○ -2.33 -2.33415071537452
Haemophilus influenzae Rd KW20  HI_0461  NP_438622.1  Q57144  291 aa hypothetical protein 0.022 ●●●○○ -2.33 -2.33313175882731
Haemophilus influenzae Rd KW20  HI_0188  NP_438357.1  P44560  tatC  256 aa Sec-independent protein translocase protein TatC 0.022 ●●●○○ -2.33 -2.33230307991518
Streptococcus pyogenes M1 5448  SP5448_07480  WP_010921977.1  500 aa DUF853 domain-containing protein 0.011 ●●●○○ -2.33 -2.3304562296281
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3757  WP_000902764.1  E8XFA2  pitA  498 aa inorganic phosphate transporter PitA 7.1e-6 ●●●○○ -2.33 -2.32848830489692
Salmonella enterica Serovar Typhimurium ST4 74  STM474_1855  WP_000156280.1  E8X8K4  yobd  152 aa DUF986 domain-containing protein 3.5e-15 ●●●○○ -2.33 -2.32704995994888
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_1417  AIK80038.1  237 aa putative membrane protein 8.1e-7 ●●●○○ -2.33 -2.32667248921816
Salmonella enterica Serovar Typhimurium ST4 74  STM474_2075  WP_000008351.1  E8XB62  179 aa hypothetical protein 4.7e-18 ●●●○○ -2.33 -2.32639373776688
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2782  AIK81371.1  43 aa hypothetical protein 7.9e-9 ●●●○○ -2.33 -2.32595297154185
Campylobacter jejuni subsp. jejuni 81-176  CJJ81176_0397  WP_002911284.1  A0A0H3PB14  311 aa D-2-hydroxyacid dehydrogenase 0.014 ●●●○○ -2.32 -2.32386499705
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3786  WP_000988813.1  E8XFD0  369 aa cellulase 0.00022 ●●●○○ -2.32 -2.31902249735207
Campylobacter jejuni subsp. jejuni 81-176  CJJ81176_0196  WP_002857378.1  A0A0H3PAN0  queE  247 aa 7-carboxy-7-deazaguanine synthase QueE 0.014 ●●●○○ -2.32 -2.31652076141
Acinetobacter baumannii ATCC 17978  A1S_0575  ABO11028.2  304 aa cysteine synthase B 4.1e-11 ●●●○○ -2.32 -2.31641439083992
Vibrio parahaemolyticus RIMD 2210633  VP_0001  BAC58264.1  Q87TR7  144 aa MioC protein 0.024 ●●●○○ -2.32 -2.31583246338322
Escherichia coli O157:H7 str. EDL933  Z2001  AAG56084.1  1247 aa nitrate reductase 1, alpha subunit 0.012 ●●●○○ -2.32 -2.31560904474794
Escherichia coli CFT073  c2512  AAN80967.1  A0A0H2V9X1  340 aa Transposase 0.027 ●●●○○ -2.31 -2.31369181848396
Salmonella enterica Serovar Typhimurium ST4 74  STM474_4779  WP_000722276.1  E8XDA7  229 aa DUF1120 domain-containing protein 2.1e-20 ●●●○○ -2.31 -2.31356907478221
Mycobacterium avium subsp. paratuberculosis K10  MAP_3241  AAS05789.1  Q73UX5  110 aa hypothetical protein 0.009 ●●●○○ -2.31 -2.31347263575776
Haemophilus influenzae Rd KW20  HI_0718  NP_438876.1  P44042  mlaA  250 aa lipoprotein 0.023 ●●●○○ -2.31 -2.3102838302606
Streptococcus pyogenes M1 5448  SP5448_08790  WP_011285746.1  105 aa hypothetical protein 0.0049 ●●●○○ -2.31 -2.31026816316874
Streptococcus pyogenes M1 5448  SP5448_08790  WP_010922719.1  309 aa peptidylprolyl isomerase PrsA 0.0049 ●●●○○ -2.31 -2.31026816316874
Salmonella enterica Serovar Typhimurium ST4 74  STM474_4099  WP_000011227.1  E8XIN1  wecC  420 aa UDP-N-acetyl-D-mannosamine dehydrogenase 6.2e-6 ●●●○○ -2.31 -2.30989214322943
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3275  WP_000475950.1  E8XAH5  499 aa APC family permease 5.9e-18 ●●●○○ -2.31 -2.30962399663046
Acinetobacter baumannii ATCC 17978  A1S_3182  ABO13579.2  473 aa glutamate synthase small chain 6.2e-20 ●●●○○ -2.31 -2.30644669342892
Mycobacterium avium subsp. paratuberculosis K10  MAP_0862  AAS03179.1  Q742H3  360 aa hypothetical protein 0.0092 ●●●○○ -2.31 -2.30593777495225
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A0202  NP_232602.1  Q7DCS6  145 aa IS1004 transposase 8.2e-6 ●●●○○ -2.31 -2.30574771763527
Vibrio parahaemolyticus RIMD 2210633  VPA_1120  BAC62463.1  Q87H45  258 aa putative enoyl-CoA hydratase/isomerase 0.034 ●●●○○ -2.31 -2.30502177448919
Vibrio cholerae O1 biovar El Tor str. N16961  VC_A0445  NP_232839.1  H9L4T4  82 aa hypothetical protein 6.0e-10 ●●●○○ -2.3 -2.30495609679893
Mycobacterium avium subsp. paratuberculosis K10  MAP_0685  AAS03002.1  Q743A0  177 aa hypothetical protein 0.0092 ●●●○○ -2.3 -2.30462300825861
Haemophilus influenzae Rd KW20  HI_0676  NP_438836.1  P44818  xerC  295 aa site-specific tyrosine recombinase XerC 0.024 ●●●○○ -2.3 -2.30378546154523
Salmonella enterica Serovar Typhimurium ST4 74  STM474_0019  WP_000235798.1  E8XG39  699 aa chitinase 1.4e-16 ●●●○○ -2.3 -2.30362367178218
Vibrio cholerae O1 biovar El Tor str. N16961  VC_1487  NP_231128.1  Q9KRZ6  80 aa hypothetical protein 6.8e-7 ●●●○○ -2.3 -2.30357520765787
Mycobacterium avium subsp. paratuberculosis K10  MAP_0309c  AAS02626.1  Q744N2  335 aa hypothetical protein 0.0092 ●●●○○ -2.3 -2.30288372665588
Streptococcus pyogenes M1 5448  SP5448_04455  WP_011284873.1  118 aa hypothetical protein 0.034 ●●●○○ -2.3 -2.30161613468616
Streptococcus pyogenes M1 5448  SP5448_04625  WP_011054796.1  200 aa hypothetical protein 0.044 ●●●○○ -2.3 -2.29969346169003
Vibrio parahaemolyticus RIMD 2210633  VP_2902  BAC61165.1  Q87KS4  377 aa hypothetical protein 0.025 ●●●○○ -2.3 -2.29895530806664
Acinetobacter baumannii ATCC 17978  A1S_0780  ABO11220.2  409 aa putative ATP-binding protein 5.2e-14 ●●●○○ -2.3 -2.29882220682472
Streptococcus pyogenes M1 5448  SP5448_05705  WP_011285508.1  59 aa nucleoside-diphosphate kinase 0.041 ●●●○○ -2.3 -2.29873212519196
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0224  NP_229881.1  Q9KVC2  259 aa lipopolysaccharide biosynthesis glycosyltransferase 2.4e-7 ●●●○○ -2.3 -2.29652500940786
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4685  AIK83219.1  213 aa phosphoribosylglycinamide formyltransferase 0.0046 ●●●○○ -2.3 -2.29642229094549
Salmonella enterica Serovar Typhimurium ST4 74  STM474_2355  WP_000778097.1  E8XEA2  napA  828 aa nitrate reductase catalytic subunit NapA 8.9e-25 ●●●○○ -2.3 -2.29535840095249
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2100  AIK80705.1  175 aa primosomal replication priB and priC family protein 5.8e-8 ●●●○○ -2.3 -2.29524350287812
Salmonella enterica Serovar Typhimurium ST4 74  STM474_2417  WP_000393522.1  E8XEG3  nuoJ  184 aa NADH-quinone oxidoreductase subunit J 0.00032 ●●●○○ -2.3 -2.29523596679422
Mycobacterium avium subsp. paratuberculosis K10  MAP_0434  AAS02751.1  Q744A7  359 aa hypothetical protein 0.0094 ●●●○○ -2.29 -2.29448385730535
Mycobacterium avium subsp. paratuberculosis K10  MAP_0064  AAS02381.1  Q744V9  ponA  877 aa PonA_1 0.0094 ●●●○○ -2.29 -2.29448385730535
Vibrio cholerae O1 biovar El Tor str. N16961  VC_1270  NP_230915.1  Q9KSI6  218 aa glyoxylase II family protein 2.8e-10 ●●●○○ -2.29 -2.29263166221647
Salmonella enterica Serovar Typhimurium ST4 74  STM474_4036  WP_000867130.1  E8XHU5  pstS  346 aa phosphate ABC transporter substrate-binding protein PstS 7.5e-6 ●●●○○ -2.29 -2.29244371487543
Mycobacterium avium subsp. paratuberculosis K10  MAP_2018c  AAS04335.1  Q73YD8  495 aa hypothetical protein 0.0095 ●●●○○ -2.29 -2.29235341045066
Serratia marcescens Strain UMH9  BVG96_21895  ASM00102.1  196 aa hypothetical protein 0.02 ●●●○○ -2.29 -2.29107784615353
Haemophilus influenzae Rd KW20  HI_1145  NP_439303.1  P43900  pheA  385 aa chorismate mutase/prephenate dehydratase 0.024 ●●●○○ -2.29 -2.28993453522256
Vibrio parahaemolyticus RIMD 2210633  VP_0846  BAC59109.1  Q87RF1  236 aa succinate dehydrogenase, iron-sulfur protein 0.025 ●●●○○ -2.29 -2.28791729942047
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3310  WP_000527859.1  E8XAL0  exbB  244 aa biopolymer transporter ExbB 1.8e-5 ●●●○○ -2.29 -2.28763109707209
Escherichia coli M12  CO715_16565  ATI07187.1  1072 aa carbamoyl-phosphate synthase large subunit 3.3e-14 ●●●○○ -2.29 -2.28520928283906
Escherichia coli CFT073  c2091  AAN80551.1  A0A0H2V9Y8  ydiP  303 aa Hypothetical transcriptional regulator ydiP 0.049 ●●●○○ -2.28 -2.28465069810588
Vibrio parahaemolyticus RIMD 2210633  VP_2083  BAC60346.1  Q87MZ3  714 aa phosphate acetyltransferase 0.026 ●●●○○ -2.28 -2.28441880255584
Acinetobacter baumannii ATCC 17978  A1S_1937  ABO12364.1  113 aa putative glutaredoxin-related protein 6.4e-11 ●●●○○ -2.28 -2.2838974291571
Vibrio parahaemolyticus RIMD 2210633  VP_2069  BAC60332.1  Q87N07  metG  676 aa methionyl-tRNA synthetase 0.026 ●●●○○ -2.28 -2.28213720664256
Vibrio parahaemolyticus RIMD 2210633  VPA_0696  BAC62039.1  Q87IB0  51 aa hypothetical protein 0.036 ●●●○○ -2.28 -2.28204337756784
Streptococcus pyogenes M1 5448  SP5448_02110  WP_010922590.1  288 aa acetyl-CoA carboxylase carboxyltransferase subunit beta 0.0078 ●●●○○ -2.28 -2.2814280682268
Vibrio parahaemolyticus RIMD 2210633  VP_1250  BAC59513.1  Q87QA0  595 aa transport ATP-binding protein CydD 0.026 ●●●○○ -2.28 -2.27835525267333
Haemophilus influenzae Rd KW20  HI_0209  NP_438378.1  P44431  dam  286 aa DNA adenine methylase 0.025 ●●●○○ -2.28 -2.2782699325522
Streptococcus pyogenes M1 5448  SP5448_07375  WP_011285429.1  49 aa hypothetical protein 0.025 ●●●○○ -2.28 -2.27758272223454
Salmonella enterica Serovar Typhimurium ST4 74  STM474_2287  WP_000023807.1  E8XDN5  440 aa MFS transporter 3.1e-15 ●●●○○ -2.28 -2.27739128884346
Acinetobacter baumannii ATCC 17978  A1S_0798  ABO11236.2  345 aa putative cell division protein (ZipA-like) 4.9e-5 ●●●○○ -2.28 -2.27688178556081
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0745  NP_230394.2  Q9KTY5  267 aa inositol monophosphatase 1.1e-9 ●●●○○ -2.28 -2.27684694523602
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