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Sorted by significance (p<0.05) and Fitness z-Scores (highest impact first):

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Pathogen Locus Protein UniProt Gene Length Product p-Value Fitness z-Score  Precise fitness z-Score
Streptococcus pyogenes M1 5448  SP5448_06855  WP_002985431.1  325 aa YvcK family protein 0.00037 ●●●●○ -3.33 -3.33313019710969
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3767  WP_000498935.1  E8XFB2  439 aa anaerobic C4-dicarboxylate transporter 2.5e-24 ●●●●○ -3.33 -3.33270722450203
Salmonella enterica Serovar Typhimurium ST4 74  STM474_0927  WP_000087085.1  E8XCP8  ybjX  322 aa DUF535 domain-containing protein 4.6e-8 ●●●●○ -3.33 -3.3302329318504
Vibrio parahaemolyticus RIMD 2210633  VP_0466  BAC58729.1  Q87SF8  151 aa conserved hypothetical protein 0.0014 ●●●●○ -3.33 -3.32659787137442
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0829  NP_230477.1  P23476  tcpB  430 aa toxin co-regulated pilus biosynthesis protein B 8.5e-8 ●●●●○ -3.32 -3.32131685451768
Salmonella enterica Serovar Typhimurium ST4 74  STM474_4647  WP_001268859.1  E8XBK3  nrdG  154 aa anaerobic ribonucleoside-triphosphate reductase-activating protein 2.2e-8 ●●●●○ -3.32 -3.31506361586413
Salmonella enterica Serovar Typhimurium SL1344  SL1344_1340  CBW17436.1  A0A0H3NKW1  ssaG  71 aa Type III secretion system apparatus 3.3e-11 ●●●●○ -3.31 -3.31426293125491
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4579  AIK83118.1  386 aa pheA <1e-323 ●●●●○ -3.31 -3.31086286403209
Vibrio cholerae O1 biovar El Tor str. N16961  VC_2726  NP_232353.1  P45781  epsK  336 aa general secretion pathway protein K 3.2e-13 ●●●●○ -3.31 -3.30971880971791
Acinetobacter baumannii ATCC 17978  A1S_2022  ABO12449.2  392 aa putative tail fiber 3.4e-38 ●●●●○ -3.31 -3.30924370738943
Vibrio parahaemolyticus RIMD 2210633  VP_0795  BAC59058.1  Q87RJ9  85 aa phosphocarrier protein HPr 0.0015 ●●●●○ -3.31 -3.3061410381844
Salmonella enterica Serovar Typhimurium SL1344  SL1344_2982  CBW19081.1  A0A0H3NFN8  nudH  176 aa RNA pyrophosphohydrolase 4.6e-13 ●●●●○ -3.3 -3.30390617114108
Salmonella enterica Serovar Typhimurium ST4 74  STM474_4542  WP_000149876.1  E8XAM4  500 aa glutamate/gamma-aminobutyrate family transporter YjeM 2.5e-35 ●●●●○ -3.3 -3.30378561233779
Salmonella enterica Serovar Typhimurium SL1344  SL1344_3677  CBW19771.1  A0A0H3NTQ2  rfaF  348 aa ADP-heptose-LPS heptosyltransferase II 1.3e-7 ●●●●○ -3.3 -3.30004225947914
Acinetobacter baumannii ATCC 17978  A1S_0238  ABO10713.2  379 aa threonine synthase pyridoxal-5'-phosphate-dependent enzyme 2.7e-38 ●●●●○ -3.3 -3.29839216944726
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_2967  AIK81552.1  150 aa phosphonate C-P lyase system protein PhnG 0.00018 ●●●●○ -3.3 -3.29695487842759
Salmonella enterica Serovar Typhimurium SL1344  SL1344_0716  CBW16814.1  A0A0H3NEC2  sdhA  588 aa succinate dehydrogenase flavoprotein subunit 1.9e-13 ●●●●○ -3.3 -3.29661286061695
Salmonella enterica Serovar Typhimurium SL1344  SL1344_3093  CBW19192.1  A0A0H3NFX5  175 aa conserved hypothetical protein 5.9e-15 ●●●●○ -3.3 -3.29641549121377
Salmonella enterica Serovar Typhimurium SL1344  SL1344_2395  CBW18497.1  A0A0H3NFL6  ptsI  575 aa phosphoenolpyruvate-protein phosphotransferase (ec 2.7.3.9) (phosphotransferase system, enzyme i) 4.2e-8 ●●●●○ -3.29 -3.29249889708217
Vibrio cholerae O1 biovar El Tor str. N16961  VC_2390  NP_232020.1  Q9KPH8  carA  379 aa carbamoyl phosphate synthase small subunit 6.2e-13 ●●●●○ -3.29 -3.28975733934777
Vibrio parahaemolyticus RIMD 2210633  VP_0644  BAC58907.1  Q87RY2  smpB  161 aa small protein B 0.0016 ●●●●○ -3.29 -3.28821513923504
Salmonella enterica Serovar Typhimurium ST4 74  STM474_1044  WP_000334547.1  E8XDK7  208 aa SOS response-associated peptidase 3.0e-8 ●●●●○ -3.28 -3.27876869225796
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0395  NP_230049.1  Q9KUW4  291 aa UTP-glucose-1-phosphate uridylyltransferase 6.3e-13 ●●●●○ -3.28 -3.2784436048225
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4025  AIK82572.1  490 aa tolC outer membrane channel 1.0e-6 ●●●●○ -3.28 -3.27763460471654
Vibrio cholerae O1 biovar El Tor str. N16961  VC_1904  NP_231538.1  Q9KQU4  164 aa leucine-responsive transcriptional regulator 4.0e-13 ●●●●○ -3.28 -3.27578052950686
Vibrio parahaemolyticus RIMD 2210633  VPA_1354  BAC62697.1  Q87GG2  352 aa putative type III secretion system EscU protein 0.0023 ●●●●○ -3.28 -3.27522450235243
Vibrio parahaemolyticus RIMD 2210633  VP_2855  BAC61118.1  Q87KX0  pfkA  320 aa 6-phosphofructokinase, isozyme I 0.0016 ●●●●○ -3.27 -3.27452390670825
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_3368  AIK81925.1  205 aa 2-oxo-3-deoxygalactonate 6-phosphate aldolase <1e-323 ●●●●○ -3.27 -3.27277461561967
Serratia marcescens Strain UMH9  BVG96_18470  ASM00599.1  272 aa shikimate dehydrogenase 0.00096 ●●●●○ -3.27 -3.27045241982941
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0260  NP_229916.1  H9L4R0  621 aa mannosyltransferase 5.9e-13 ●●●●○ -3.27 -3.2697975079716
Vibrio parahaemolyticus RIMD 2210633  VP_0708  BAC58971.1  Q87RR9  183 aa histidinol phosphatase-related protein 0.0017 ●●●●○ -3.27 -3.2673389459975
Serratia marcescens Strain UMH9  BVG96_18255  ASL99448.1  171 aa chorismate lyase 0.0025 ●●●●○ -3.27 -3.26505081114961
Haemophilus influenzae Rd KW20  HI_0312  NP_438478.1  P44631  ruvB  335 aa Holliday junction DNA helicase RuvB 0.0016 ●●●●○ -3.26 -3.26393275129934
Streptococcus pyogenes M1 5448  SP5448_02750  WP_002988906.1  74 aa DUF4059 family protein 0.0052 ●●●●○ -3.26 -3.26391396924902
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0347  NP_230001.1  Q9KV11  hfq  87 aa RNA-binding protein Hfq 5.2e-13 ●●●●○ -3.26 -3.25737071006143
Salmonella enterica Serovar Typhimurium ST4 74  STM474_4354  WP_000362359.1  E8XLB4  nfi  223 aa deoxyribonuclease V 2.1e-9 ●●●●○ -3.25 -3.25467617367594
Salmonella enterica Serovar Typhimurium SL1344  SL1344_1354  CBW17450.1  A0A0H3NB87  ssaS  88 aa Type III secretion system apparatus 2.8e-11 ●●●●○ -3.25 -3.25335885572266
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3939  WP_001682335.1  E8XGW3  300 aa EamA family transporter 5.7e-8 ●●●●○ -3.25 -3.25173230782395
Acinetobacter baumannii ATCC 17978  A1S_2534  ABO12951.2  277 aa sulfate transport protein 1.2e-48 ●●●●○ -3.25 -3.25032743552786
Acinetobacter baumannii ATCC 17978  A1S_2369  ABO12788.2  264 aa putative membrane protein 6.3e-28 ●●●●○ -3.25 -3.24931031719608
Serratia marcescens Strain UMH9  BVG96_20470  ASL99848.1  287 aa F0F1 ATP synthase subunit gamma 0.00059 ●●●●○ -3.25 -3.24769579475773
Serratia marcescens Strain UMH9  BVG96_00865  ASL96244.1  118 aa 50S ribosomal protein L19 0.0014 ●●●●○ -3.25 -3.24721653475819
Salmonella enterica Serovar Typhimurium ST4 74  STM474_0609  WP_001139583.1  E8X960  fepE  378 aa LPS O-antigen length regulator 1.3e-5 ●●●●○ -3.25 -3.24580964649241
Acinetobacter baumannii ATCC 17978  A1S_0239  ABO10714.2  433 aa homoserine dehydrogenase 9.2e-35 ●●●●○ -3.25 -3.24542030644483
Salmonella enterica Serovar Typhimurium ST4 74  STM474_4024  WP_000461381.1  E8XHT3  320 aa membrane protein 9.2e-16 ●●●●○ -3.24 -3.24138236644488
Vibrio cholerae O1 biovar El Tor str. N16961  VC_1819  NP_231453.1  Q9KR28  506 aa aldehyde dehydrogenase 3.9e-8 ●●●●○ -3.24 -3.23796235547442
Salmonella enterica Serovar Typhimurium ST4 74  STM474_1194  WP_000044664.1  E8XEW5  fabf  413 aa beta-ketoacyl-ACP synthase II 1.6e-5 ●●●●○ -3.24 -3.23683693139239
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4503  AIK83041.1  41 aa hypothetical protein 4.2e-7 ●●●●○ -3.24 -3.23614030663516
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0242  NP_229899.1  Q06951  rfbB  463 aa phosphomannomutase 2.1e-15 ●●●●○ -3.23 -3.23047865544378
Salmonella enterica Serovar Typhimurium ST4 74  STM474_4308  WP_001025919.1  E8XL80  oxyR  305 aa DNA-binding transcriptional regulator OxyR 1.4e-8 ●●●●○ -3.23 -3.23007968196703
Salmonella enterica Serovar Typhimurium ST4 74  STM474_4427  WP_000019219.1  E8X8Z5  ubiC  165 aa chorismate--pyruvate lyase 5.9e-25 ●●●●○ -3.23 -3.22864756516046
Streptococcus pyogenes M1 5448  SP5448_02105  WP_010922591.1  454 aa acetyl-CoA carboxylase biotin carboxylase subunit 0.00028 ●●●●○ -3.22 -3.22449917282837
Mycobacterium avium subsp. paratuberculosis K10  MAP_1438c  AAS03755.1  Q740B3  lipH  327 aa LipH 0.00073 ●●●●○ -3.22 -3.22193994170737
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0275  NP_229931.1  Q9KV81  purD  429 aa phosphoribosylamine--glycine ligase 8.2e-13 ●●●●○ -3.22 -3.22022930950269
Salmonella enterica Serovar Typhimurium ST4 74  STM474_0380  WP_000433131.1  E8XJR4  yahN  210 aa transporter 1.8e-25 ●●●●○ -3.22 -3.21936926969833
Streptococcus pyogenes M1 5448  SP5448_04080  WP_002984095.1  180 aa GNAT family N-acetyltransferase 0.00047 ●●●●○ -3.22 -3.21584714434578
Acinetobacter baumannii ATCC 17978  A1S_3051  ABO13448.2  361 aa hypothetical protein 2.0e-33 ●●●●○ -3.21 -3.20935099931946
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3474  WP_000922736.1  E8XCD1  yrbG  325 aa calcium/sodium antiporter 7.2e-23 ●●●●○ -3.21 -3.20839733832513
Acinetobacter baumannii ATCC 17978  A1S_2128  ABO12555.1  245 aa aconitate hydratase 2 2.8e-9 ●●●●○ -3.2 -3.20427538432909
Vibrio cholerae O1 biovar El Tor str. N16961  VC_1205  NP_230850.1  Q9KSQ1  hutI  402 aa imidazolonepropionase 1.7e-12 ●●●●○ -3.2 -3.20345895107432
Salmonella enterica Serovar Typhimurium SL1344  SL1344_2289  CBW18391.1  A0A0H3NNX7  nuoJ  184 aa NADH dehydrogenase I chain J 3.5e-9 ●●●●○ -3.2 -3.20133893408525
Serratia marcescens Strain UMH9  BVG96_18950  ASL99573.1  336 aa SPOR domain-containing protein 0.00017 ●●●●○ -3.2 -3.20072998264433
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0211  NP_229868.2  Q9KVD5  pyrE  213 aa orotate phosphoribosyltransferase 1.9e-12 ●●●●○ -3.2 -3.20063506101954
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0593  NP_230243.1  Q9KUC9  167 aa 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase 1.0e-13 ●●●●○ -3.2 -3.19697465325481
Salmonella enterica Serovar Typhimurium SL1344  SL1344_1344  CBW17440.1  A0A0H3NB80  182 aa hypothetical pathogenicity island protein 5.6e-10 ●●●●○ -3.2 -3.1967700801843
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3085  WP_000029738.1  E8X8M4  ygcB  887 aa CRISPR-associated helicase/endonuclease Cas3 2.2e-7 ●●●●○ -3.2 -3.19666332454104
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0052  NP_229711.1  Q9KVT7  purE  161 aa 5-(carboxyamino)imidazole ribonucleotide mutase 9.4e-13 ●●●●○ -3.2 -3.19590955531719
Salmonella enterica Serovar Typhimurium ST4 74  STM474_1127  WP_000988585.1  E8XE91  368 aa Gfo/Idh/MocA family oxidoreductase 1.8e-39 ●●●●○ -3.19 -3.19498638927213
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3774  WP_001196084.1  E8XFB9  yhjB  200 aa response regulator transcription factor 1.9e-21 ●●●●○ -3.19 -3.19493496361243
Haemophilus influenzae Rd KW20  HI_0361  NP_438523.1  P44662  306 aa iron (chelated) transporter ATP-binding protein 0.0021 ●●●●○ -3.19 -3.19331416403592
Haemophilus influenzae Rd KW20  HI_1675  NP_439817.1  P45310  moaC  160 aa molybdenum cofactor biosynthesis protein MoaC 0.0021 ●●●●○ -3.19 -3.19331416403592
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0276  NP_229932.1  Q9KV80  purH  530 aa bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 1.2e-12 ●●●●○ -3.19 -3.19323963913255
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_4578  AIK83116.1  373 aa tyrA 2.8e-11 ●●●●○ -3.19 -3.1852244890347
Acinetobacter baumannii ATCC 17978  A1S_1421  ABO11849.1  559 aa malonate decarboxylase alpha subunit 4.2e-24 ●●●●○ -3.18 -3.1847544836983
Vibrio parahaemolyticus RIMD 2210633  VP_0231  BAC58494.1  Q87T39  200 aa putative UDP-galactose phosphate transferase 0.0022 ●●●●○ -3.18 -3.18471908789555
Vibrio parahaemolyticus RIMD 2210633  VP_0829  BAC59092.1  Q87RG7  378 aa N-acetylglucosamine-6-phosphate deacetylase 0.0022 ●●●●○ -3.18 -3.18433432342915
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3531  WP_000123188.1  E8XD74  cafA  489 aa ribonuclease G 2.1e-8 ●●●●○ -3.18 -3.18337352693894
Vibrio parahaemolyticus RIMD 2210633  VP_2185  BAC60448.1  Q87MP6  purF  504 aa amidophosphoribosyltransferase 0.0022 ●●●●○ -3.18 -3.18249900670431
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0566  NP_230217.1  Q9KUF5  456 aa protease Do 1.4e-12 ●●●●○ -3.18 -3.17539430602498
Salmonella enterica Serovar Typhimurium SL1344  SL1344_0151  CBW16254.1  E1W823  pdhR  254 aa pyruvate dehydrogenase complex repressor 1.7e-9 ●●●●○ -3.17 -3.172811032972
Serratia marcescens Strain UMH9  BVG96_20475  ASL99849.1  460 aa ATP synthase subunit beta 0.00064 ●●●●○ -3.17 -3.17169213404537
Salmonella enterica Serovar Typhimurium ST4 74  STM474_2857  WP_000794278.1  E8XJ82  91 aa hypothetical protein 3.8e-23 ●●●●○ -3.17 -3.17137086853305
Vibrio parahaemolyticus RIMD 2210633  VP_3033  BAC61296.1  Q87KE4  aroE  277 aa shikimate 5-dehydrogenase 0.0023 ●●●●○ -3.17 -3.16969689547716
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0626  NP_230275.1  Q9KU97  hemL  432 aa glutamate-1-semialdehyde aminotransferase 1.3e-12 ●●●●○ -3.17 -3.1689361165177
Streptococcus pyogenes M1 5448  SP5448_08195  WP_002991828.1  372 aa ribosome biogenesis GTPase YqeH 0.00044 ●●●●○ -3.17 -3.16778031944254
Vibrio parahaemolyticus RIMD 2210633  VP_1020  BAC59283.1  Q87QX9  aroA  426 aa 3-phosphoshikimate 1-carboxyvinyltransferase 0.0023 ●●●●○ -3.17 -3.16523300764541
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0223  NP_229880.1  Q9KVC3  345 aa ADP-heptose--LPS heptosyltransferase II 1.3e-12 ●●●●○ -3.16 -3.16484022140022
Vibrio cholerae O1 biovar El Tor str. N16961  VC_0034  NP_229693.1  P32557  dsbA  200 aa thiol:disulfide interchange protein 9.2e-13 ●●●●○ -3.16 -3.16450842282324
Acinetobacter baumannii ATCC 17978  A1S_0753  ABO11193.2  A3M2P9  nuoB  225 aa NADH dehydrogenase I chain B 1.5e-18 ●●●●○ -3.16 -3.16385781106942
Campylobacter jejuni subsp. jejuni 81-176  CJJ81176_1675  WP_002869285.1  A0A0H3PI81  gltA  422 aa citrate synthase 0.0014 ●●●●○ -3.16 -3.16312136747
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1  VK055_5017  AIK83543.1  722 aa tyrosine-protein kinase etk 2.1e-12 ●●●●○ -3.16 -3.16153205358015
Vibrio cholerae O1 biovar El Tor str. N16961  VC_2412  NP_232042.1  Q9KPF6  lpd  475 aa dihydrolipoamide dehydrogenase 6.5e-14 ●●●●○ -3.16 -3.1612623062662
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3679  WP_000619387.1  E8XEL5  yhgI  191 aa iron-sulfur cluster biogenesis protein NfuA 2.5e-8 ●●●●○ -3.16 -3.15956984757032
Mycobacterium avium subsp. paratuberculosis K10  MAP_1145c  AAS03462.1  Q741E6  393 aa hypothetical protein 0.0009 ●●●●○ -3.15 -3.1540195668544
Salmonella enterica Serovar Typhimurium ST4 74  STM474_1972  WP_010989033.1  E8XA86  479 aa cell wall-associated hydrolase 1.3e-20 ●●●●○ -3.15 -3.15220334330578
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3955  WP_001113558.1  E8XGX8  494 aa carbohydrate kinase 4.6e-8 ●●●●○ -3.15 -3.15208102703196
Vibrio cholerae O1 biovar El Tor str. N16961  VC_2734  NP_232360.1  P45777  epsC  305 aa general secretion pathway protein C 3.5e-10 ●●●●○ -3.15 -3.15125817410767
Vibrio parahaemolyticus RIMD 2210633  VP_1249  BAC59512.1  Q87QA1  573 aa transport ATP-binding protein CydC 0.0024 ●●●●○ -3.15 -3.15081388711784
Salmonella enterica Serovar Typhimurium ST4 74  STM474_3274  WP_000100106.1  E8XAH4  185 aa DUF3156 family protein 2.0e-15 ●●●●○ -3.15 -3.14788185337967
Salmonella enterica Serovar Typhimurium ST4 74  STM474_4459  WP_000083640.1  E8X9R4  yjcC  533 aa EAL domain-containing protein 1.2e-24 ●●●●○ -3.15 -3.1467662552612
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